The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder

Sonja M. C. de Zwarte; Rachel M. Brouwer; Ingrid Agartz; Martin Alda; Andre Aleman; Kathryn I. Alpert; Carrie E. Bearden; Alessandro Bertolino; Catherine Bois; Aurora Bonvino; Elvira Bramon; Elizabeth E. L. Buimer; Wiepke Cahn; Dara M. Cannon; Tyrone D. Cannon; Xavier Caseras; Josefina Castro-Fornieles; Qiang Chen; Yoonho Chung; Elena De la Serna; Annabella Di Giorgio; Gaelle E. Doucet; Mehmet Cagdas Eker; Susanne Erk; Scott C. Fears; Sonya F. Foley; Sophia Frangou; Andrew Frankland; Janice M. Fullerton; David C. Glahn; Vina M. Goghari; Aaron L. Goldman; Ali Saffet Gonul; Oliver Gruber; Lieuwe de Haan; Tomas Hajek; Emma L. Hawkins; Andreas Heinz; Manon H. J. Hillegers; Hilleke E. Hulshoff Pol; Christina M. Hultman; Martin Ingvar; Viktoria Johansson; Erik G. Jonsson; Fergus Kane; Matthew J. Kempton; Marinka M. G. Koenis; Miloslav Kopecek; Lydia Krabbendam; Bernd Kraemer; Stephen M. Lawrie; Rhoshel K. Lenroot; Machteld Marcelis; Jan-Bernard C. Marsman; Venkata S. Mattay; Colm McDonald; Andreas Meyer-Lindenberg; Stijn Michielse; Philip B. Mitchell; Dolores Moreno; Robin M. Murray; Benson Mwangi; Pablo Najt; Emma Neilson; Jason Newport; Jim van Os; Bronwyn Overs; Aysegul Ozerdem; Marco M. Picchioni; Anja Richter; Gloria Roberts; Aybala Saricicek Aydogan; Peter R. Schofield; Fatma Simsek; Jair C. Soares; Gisela Sugranyes; Timothea Toulopoulou; Giulia Tronchin; Henrik Walter; Lei Wang; Daniel R. Weinberger; Heather C. Whalley; Nefize Yalin; Ole A. Andreassen; Christopher R. K. Ching; Theo G. M. van Erp; Jessica A. Turner; Neda Jahanshad; Paul M. Thompson; Rene S. Kahn; Neeltje E. M. van Haren

doi:10.1016/j.biopsych.2019.03.985

The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder

Sonja M. C. de Zwarte^*, Rachel M. Brouwer, Ingrid Agartz, Martin Alda, Andre Aleman, Kathryn I. Alpert, Carrie E. Bearden, Alessandro Bertolino, Catherine Bois, Aurora Bonvino, Elvira Bramon, Elizabeth E. L. Buimer, Wiepke Cahn, Dara M. Cannon, Tyrone D. Cannon, Xavier Caseras, Josefina Castro-Fornieles, Qiang Chen, Yoonho Chung, Elena De la SernaAnnabella Di Giorgio, Gaelle E. Doucet, Mehmet Cagdas Eker, Susanne Erk, Scott C. Fears, Sonya F. Foley, Sophia Frangou, Andrew Frankland, Janice M. Fullerton, David C. Glahn, Vina M. Goghari, Aaron L. Goldman, Ali Saffet Gonul, Oliver Gruber, Lieuwe de Haan, Tomas Hajek, Emma L. Hawkins, Andreas Heinz, Manon H. J. Hillegers, Hilleke E. Hulshoff Pol, Christina M. Hultman, Martin Ingvar, Viktoria Johansson, Erik G. Jonsson, Fergus Kane, Matthew J. Kempton, Marinka M. G. Koenis, Miloslav Kopecek, Lydia Krabbendam, Bernd Kraemer, Stephen M. Lawrie, Rhoshel K. Lenroot, Machteld Marcelis, Jan-Bernard C. Marsman, Venkata S. Mattay, Colm McDonald, Andreas Meyer-Lindenberg, Stijn Michielse, Philip B. Mitchell, Dolores Moreno, Robin M. Murray, Benson Mwangi, Pablo Najt, Emma Neilson, Jason Newport, Jim van Os, Bronwyn Overs, Aysegul Ozerdem, Marco M. Picchioni, Anja Richter, Gloria Roberts, Aybala Saricicek Aydogan, Peter R. Schofield, Fatma Simsek, Jair C. Soares, Gisela Sugranyes, Timothea Toulopoulou, Giulia Tronchin, Henrik Walter, Lei Wang, Daniel R. Weinberger, Heather C. Whalley, Nefize Yalin, Ole A. Andreassen, Christopher R. K. Ching, Theo G. M. van Erp, Jessica A. Turner, Neda Jahanshad, Paul M. Thompson, Rene S. Kahn, Neeltje E. M. van Haren

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	545-556
Number of pages	12
Journal	Biological Psychiatry
Volume	86
Issue number	7
DOIs	https://doi.org/10.1016/j.biopsych.2019.03.985
Publication status	Published - 1 Oct 2019

Keywords

Bipolar disorder
Familial risk
Imaging
Meta-analysis
Neurodevelopment
Schizophrenia
GRAY-MATTER VOLUME
VOXEL-BASED MORPHOMETRY
HIGH GENETIC RISK
SOCIOECONOMIC-STATUS
SCHOOL PERFORMANCE
TWINS DISCORDANT
PREMORBID IQ
METAANALYSIS
CHILDHOOD
PREDISPOSITION

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10.1016/j.biopsych.2019.03.985

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de Zwarte, S. M. C., Brouwer, R. M., Agartz, I., Alda, M., Aleman, A., Alpert, K. I., Bearden, C. E., Bertolino, A., Bois, C., Bonvino, A., Bramon, E., Buimer, E. E. L., Cahn, W., Cannon, D. M., Cannon, T. D., Caseras, X., Castro-Fornieles, J., Chen, Q., Chung, Y., ... van Haren, N. E. M. (2019). The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder. Biological Psychiatry, 86(7), 545-556. https://doi.org/10.1016/j.biopsych.2019.03.985

de Zwarte, Sonja M. C. ; Brouwer, Rachel M. ; Agartz, Ingrid ; Alda, Martin ; Aleman, Andre ; Alpert, Kathryn I. ; Bearden, Carrie E. ; Bertolino, Alessandro ; Bois, Catherine ; Bonvino, Aurora ; Bramon, Elvira ; Buimer, Elizabeth E. L. ; Cahn, Wiepke ; Cannon, Dara M. ; Cannon, Tyrone D. ; Caseras, Xavier ; Castro-Fornieles, Josefina ; Chen, Qiang ; Chung, Yoonho ; De la Serna, Elena ; Di Giorgio, Annabella ; Doucet, Gaelle E. ; Eker, Mehmet Cagdas ; Erk, Susanne ; Fears, Scott C. ; Foley, Sonya F. ; Frangou, Sophia ; Frankland, Andrew ; Fullerton, Janice M. ; Glahn, David C. ; Goghari, Vina M. ; Goldman, Aaron L. ; Gonul, Ali Saffet ; Gruber, Oliver ; de Haan, Lieuwe ; Hajek, Tomas ; Hawkins, Emma L. ; Heinz, Andreas ; Hillegers, Manon H. J. ; Pol, Hilleke E. Hulshoff ; Hultman, Christina M. ; Ingvar, Martin ; Johansson, Viktoria ; Jonsson, Erik G. ; Kane, Fergus ; Kempton, Matthew J. ; Koenis, Marinka M. G. ; Kopecek, Miloslav ; Krabbendam, Lydia ; Kraemer, Bernd ; Lawrie, Stephen M. ; Lenroot, Rhoshel K. ; Marcelis, Machteld ; Marsman, Jan-Bernard C. ; Mattay, Venkata S. ; McDonald, Colm ; Meyer-Lindenberg, Andreas ; Michielse, Stijn ; Mitchell, Philip B. ; Moreno, Dolores ; Murray, Robin M. ; Mwangi, Benson ; Najt, Pablo ; Neilson, Emma ; Newport, Jason ; van Os, Jim ; Overs, Bronwyn ; Ozerdem, Aysegul ; Picchioni, Marco M. ; Richter, Anja ; Roberts, Gloria ; Aydogan, Aybala Saricicek ; Schofield, Peter R. ; Simsek, Fatma ; Soares, Jair C. ; Sugranyes, Gisela ; Toulopoulou, Timothea ; Tronchin, Giulia ; Walter, Henrik ; Wang, Lei ; Weinberger, Daniel R. ; Whalley, Heather C. ; Yalin, Nefize ; Andreassen, Ole A. ; Ching, Christopher R. K. ; van Erp, Theo G. M. ; Turner, Jessica A. ; Jahanshad, Neda ; Thompson, Paul M. ; Kahn, Rene S. ; van Haren, Neeltje E. M. / The Association Between Familial Risk and Brain Abnormalities Is Disease Specific : An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder. In: Biological Psychiatry. 2019 ; Vol. 86, No. 7. pp. 545-556.

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title = "The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder",

keywords = "Bipolar disorder, Familial risk, Imaging, Meta-analysis, Neurodevelopment, Schizophrenia, GRAY-MATTER VOLUME, VOXEL-BASED MORPHOMETRY, HIGH GENETIC RISK, SOCIOECONOMIC-STATUS, SCHOOL PERFORMANCE, TWINS DISCORDANT, PREMORBID IQ, METAANALYSIS, CHILDHOOD, PREDISPOSITION",

author = "{de Zwarte}, {Sonja M. C.} and Brouwer, {Rachel M.} and Ingrid Agartz and Martin Alda and Andre Aleman and Alpert, {Kathryn I.} and Bearden, {Carrie E.} and Alessandro Bertolino and Catherine Bois and Aurora Bonvino and Elvira Bramon and Buimer, {Elizabeth E. L.} and Wiepke Cahn and Cannon, {Dara M.} and Cannon, {Tyrone D.} and Xavier Caseras and Josefina Castro-Fornieles and Qiang Chen and Yoonho Chung and {De la Serna}, Elena and {Di Giorgio}, Annabella and Doucet, {Gaelle E.} and Eker, {Mehmet Cagdas} and Susanne Erk and Fears, {Scott C.} and Foley, {Sonya F.} and Sophia Frangou and Andrew Frankland and Fullerton, {Janice M.} and Glahn, {David C.} and Goghari, {Vina M.} and Goldman, {Aaron L.} and Gonul, {Ali Saffet} and Oliver Gruber and {de Haan}, Lieuwe and Tomas Hajek and Hawkins, {Emma L.} and Andreas Heinz and Hillegers, {Manon H. J.} and Pol, {Hilleke E. Hulshoff} and Hultman, {Christina M.} and Martin Ingvar and Viktoria Johansson and Jonsson, {Erik G.} and Fergus Kane and Kempton, {Matthew J.} and Koenis, {Marinka M. G.} and Miloslav Kopecek and Lydia Krabbendam and Bernd Kraemer and Lawrie, {Stephen M.} and Lenroot, {Rhoshel K.} and Machteld Marcelis and Marsman, {Jan-Bernard C.} and Mattay, {Venkata S.} and Colm McDonald and Andreas Meyer-Lindenberg and Stijn Michielse and Mitchell, {Philip B.} and Dolores Moreno and Murray, {Robin M.} and Benson Mwangi and Pablo Najt and Emma Neilson and Jason Newport and {van Os}, Jim and Bronwyn Overs and Aysegul Ozerdem and Picchioni, {Marco M.} and Anja Richter and Gloria Roberts and Aydogan, {Aybala Saricicek} and Schofield, {Peter R.} and Fatma Simsek and Soares, {Jair C.} and Gisela Sugranyes and Timothea Toulopoulou and Giulia Tronchin and Henrik Walter and Lei Wang and Weinberger, {Daniel R.} and Whalley, {Heather C.} and Nefize Yalin and Andreassen, {Ole A.} and Ching, {Christopher R. K.} and {van Erp}, {Theo G. M.} and Turner, {Jessica A.} and Neda Jahanshad and Thompson, {Paul M.} and Kahn, {Rene S.} and {van Haren}, {Neeltje E. M.}",

year = "2019",

month = oct,

day = "1",

doi = "10.1016/j.biopsych.2019.03.985",

language = "English",

volume = "86",

pages = "545--556",

journal = "Biological Psychiatry",

issn = "0006-3223",

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number = "7",

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de Zwarte, SMC, Brouwer, RM, Agartz, I, Alda, M, Aleman, A, Alpert, KI, Bearden, CE, Bertolino, A, Bois, C, Bonvino, A, Bramon, E, Buimer, EEL, Cahn, W, Cannon, DM, Cannon, TD, Caseras, X, Castro-Fornieles, J, Chen, Q, Chung, Y, De la Serna, E, Di Giorgio, A, Doucet, GE, Eker, MC, Erk, S, Fears, SC, Foley, SF, Frangou, S, Frankland, A, Fullerton, JM, Glahn, DC, Goghari, VM, Goldman, AL, Gonul, AS, Gruber, O, de Haan, L, Hajek, T, Hawkins, EL, Heinz, A, Hillegers, MHJ, Pol, HEH, Hultman, CM, Ingvar, M, Johansson, V, Jonsson, EG, Kane, F, Kempton, MJ, Koenis, MMG, Kopecek, M, Krabbendam, L, Kraemer, B, Lawrie, SM, Lenroot, RK, Marcelis, M, Marsman, J-BC, Mattay, VS, McDonald, C, Meyer-Lindenberg, A, Michielse, S, Mitchell, PB, Moreno, D, Murray, RM, Mwangi, B, Najt, P, Neilson, E, Newport, J, van Os, J, Overs, B, Ozerdem, A, Picchioni, MM, Richter, A, Roberts, G, Aydogan, AS, Schofield, PR, Simsek, F, Soares, JC, Sugranyes, G, Toulopoulou, T, Tronchin, G, Walter, H, Wang, L, Weinberger, DR, Whalley, HC, Yalin, N, Andreassen, OA, Ching, CRK, van Erp, TGM, Turner, JA, Jahanshad, N, Thompson, PM, Kahn, RS & van Haren, NEM 2019, 'The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder', Biological Psychiatry, vol. 86, no. 7, pp. 545-556. https://doi.org/10.1016/j.biopsych.2019.03.985

The Association Between Familial Risk and Brain Abnormalities Is Disease Specific : An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder. / de Zwarte, Sonja M. C.; Brouwer, Rachel M.; Agartz, Ingrid; Alda, Martin; Aleman, Andre; Alpert, Kathryn I.; Bearden, Carrie E.; Bertolino, Alessandro; Bois, Catherine; Bonvino, Aurora; Bramon, Elvira; Buimer, Elizabeth E. L.; Cahn, Wiepke; Cannon, Dara M.; Cannon, Tyrone D.; Caseras, Xavier; Castro-Fornieles, Josefina; Chen, Qiang; Chung, Yoonho; De la Serna, Elena; Di Giorgio, Annabella; Doucet, Gaelle E.; Eker, Mehmet Cagdas; Erk, Susanne; Fears, Scott C.; Foley, Sonya F.; Frangou, Sophia; Frankland, Andrew; Fullerton, Janice M.; Glahn, David C.; Goghari, Vina M.; Goldman, Aaron L.; Gonul, Ali Saffet; Gruber, Oliver; de Haan, Lieuwe; Hajek, Tomas; Hawkins, Emma L.; Heinz, Andreas; Hillegers, Manon H. J.; Pol, Hilleke E. Hulshoff; Hultman, Christina M.; Ingvar, Martin; Johansson, Viktoria; Jonsson, Erik G.; Kane, Fergus; Kempton, Matthew J.; Koenis, Marinka M. G.; Kopecek, Miloslav; Krabbendam, Lydia; Kraemer, Bernd; Lawrie, Stephen M.; Lenroot, Rhoshel K.; Marcelis, Machteld; Marsman, Jan-Bernard C.; Mattay, Venkata S.; McDonald, Colm; Meyer-Lindenberg, Andreas; Michielse, Stijn; Mitchell, Philip B.; Moreno, Dolores; Murray, Robin M.; Mwangi, Benson; Najt, Pablo; Neilson, Emma; Newport, Jason; van Os, Jim; Overs, Bronwyn; Ozerdem, Aysegul; Picchioni, Marco M.; Richter, Anja; Roberts, Gloria; Aydogan, Aybala Saricicek; Schofield, Peter R.; Simsek, Fatma; Soares, Jair C.; Sugranyes, Gisela; Toulopoulou, Timothea; Tronchin, Giulia; Walter, Henrik; Wang, Lei; Weinberger, Daniel R.; Whalley, Heather C.; Yalin, Nefize; Andreassen, Ole A.; Ching, Christopher R. K.; van Erp, Theo G. M.; Turner, Jessica A.; Jahanshad, Neda; Thompson, Paul M.; Kahn, Rene S.; van Haren, Neeltje E. M.

In: Biological Psychiatry, Vol. 86, No. 7, 01.10.2019, p. 545-556.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The Association Between Familial Risk and Brain Abnormalities Is Disease Specific

T2 - An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder

AU - de Zwarte, Sonja M. C.

AU - Brouwer, Rachel M.

AU - Agartz, Ingrid

AU - Alda, Martin

AU - Aleman, Andre

AU - Alpert, Kathryn I.

AU - Bearden, Carrie E.

AU - Bertolino, Alessandro

AU - Bois, Catherine

AU - Bonvino, Aurora

AU - Bramon, Elvira

AU - Buimer, Elizabeth E. L.

AU - Cahn, Wiepke

AU - Cannon, Dara M.

AU - Cannon, Tyrone D.

AU - Caseras, Xavier

AU - Castro-Fornieles, Josefina

AU - Chen, Qiang

AU - Chung, Yoonho

AU - De la Serna, Elena

AU - Di Giorgio, Annabella

AU - Doucet, Gaelle E.

AU - Eker, Mehmet Cagdas

AU - Erk, Susanne

AU - Fears, Scott C.

AU - Foley, Sonya F.

AU - Frangou, Sophia

AU - Frankland, Andrew

AU - Fullerton, Janice M.

AU - Glahn, David C.

AU - Goghari, Vina M.

AU - Goldman, Aaron L.

AU - Gonul, Ali Saffet

AU - Gruber, Oliver

AU - de Haan, Lieuwe

AU - Hajek, Tomas

AU - Hawkins, Emma L.

AU - Heinz, Andreas

AU - Hillegers, Manon H. J.

AU - Pol, Hilleke E. Hulshoff

AU - Hultman, Christina M.

AU - Ingvar, Martin

AU - Johansson, Viktoria

AU - Jonsson, Erik G.

AU - Kane, Fergus

AU - Kempton, Matthew J.

AU - Koenis, Marinka M. G.

AU - Kopecek, Miloslav

AU - Krabbendam, Lydia

AU - Kraemer, Bernd

AU - Lawrie, Stephen M.

AU - Lenroot, Rhoshel K.

AU - Marcelis, Machteld

AU - Marsman, Jan-Bernard C.

AU - Mattay, Venkata S.

AU - McDonald, Colm

AU - Meyer-Lindenberg, Andreas

AU - Michielse, Stijn

AU - Mitchell, Philip B.

AU - Moreno, Dolores

AU - Murray, Robin M.

AU - Mwangi, Benson

AU - Najt, Pablo

AU - Neilson, Emma

AU - Newport, Jason

AU - van Os, Jim

AU - Overs, Bronwyn

AU - Ozerdem, Aysegul

AU - Picchioni, Marco M.

AU - Richter, Anja

AU - Roberts, Gloria

AU - Aydogan, Aybala Saricicek

AU - Schofield, Peter R.

AU - Simsek, Fatma

AU - Soares, Jair C.

AU - Sugranyes, Gisela

AU - Toulopoulou, Timothea

AU - Tronchin, Giulia

AU - Walter, Henrik

AU - Wang, Lei

AU - Weinberger, Daniel R.

AU - Whalley, Heather C.

AU - Yalin, Nefize

AU - Andreassen, Ole A.

AU - Ching, Christopher R. K.

AU - van Erp, Theo G. M.

AU - Turner, Jessica A.

AU - Jahanshad, Neda

AU - Thompson, Paul M.

AU - Kahn, Rene S.

AU - van Haren, Neeltje E. M.

PY - 2019/10/1

Y1 - 2019/10/1

KW - Bipolar disorder

KW - Familial risk

KW - Imaging

KW - Meta-analysis

KW - Neurodevelopment

KW - Schizophrenia

KW - GRAY-MATTER VOLUME

KW - VOXEL-BASED MORPHOMETRY

KW - HIGH GENETIC RISK

KW - SOCIOECONOMIC-STATUS

KW - SCHOOL PERFORMANCE

KW - TWINS DISCORDANT

KW - PREMORBID IQ

KW - METAANALYSIS

KW - CHILDHOOD

KW - PREDISPOSITION

U2 - 10.1016/j.biopsych.2019.03.985

DO - 10.1016/j.biopsych.2019.03.985

M3 - Article

C2 - 31443932

VL - 86

SP - 545

EP - 556

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 7

ER -