@article{ff118606e5744f8a972d7d4bed846dab,
title = "The association between coffee consumption and bladder cancer in the bladder cancer epidemiology and nutritional determinants (BLEND) international pooled study",
abstract = "BackgroundInconsistent results for coffee consumption and bladder cancer (BC) risk have been shown in epidemiological studies. This research aims to increase the understanding of the association between coffee consumption and BC risk by bringing together worldwide case-control studies on this topic.MethodsData were collected from 13 case-control comprising of 5,911 cases and 16,172 controls. Pooled multivariate odds ratios (ORs), with corresponding 95% confidence intervals (CIs), were obtained using multilevel logistic regression models. Furthermore, linear dose-response relationships were examined using fractional polynomial models.ResultsNo association of BC risk was observed with coffee consumption among smokers. However, after adjustment for age, gender, and smoking, the risk was significantly increased for never smokers (ever vs. never coffee consumers: ORmodel2 1.30, 95% CI 1.06-1.59; heavy (>4 cups/day) coffee consumers vs. never coffee consumers: ORmodel2 1.52, 95% CI 1.18-1.97, p trend=0.23). In addition, dose-response analyses, in both the overall population and among never smokers, also showed a significant increased BC risk for coffee consumption of more than four cups per day. Among smokers, a significant increased BC risk was shown only after consumption of more than six cups per day.ConclusionThis research suggests that positive associations between coffee consumption and BC among never smokers but not smokers.",
keywords = "Bladder cancer, Coffee consumption, Smoking, Dose-response analyses, Population-attributable risk, TOBACCO SMOKING, RISK-FACTORS, RECALL BIAS, TEA CONSUMPTION, FLUID INTAKE, CAFFEINE, DRINKING, OCCUPATION, MORTALITY, ALCOHOL",
author = "Yu, {Evan Yi-Wen} and Anke Wesselius and {van Osch}, Frits and Stern, {Mariana Carla} and Xuejuan Jiang and Eliane Kellen and Chih-Ming Lu and Hermann Pohlabeln and Gunnar Steineck and James Marshall and Allam, {Mohamed Farouk} and {La Vecchia}, Carlo and Johnson, {Kenneth C.} and Simone Benhamou and Zuo-Feng Zhang and Cristina Bosetti and Taylor, {Jack A.} and Zeegers, {Maurice P.}",
note = "Funding Information: This work was partly funded by the Word Cancer Research Fund International (WCRF 2012/590) and European Commission. The Hessen Case–control study on bladder cancer was supported by the Bundesanstalt f{\"u}r Arbeitsschutz (No. F 1287). The Kaohsiung study was supported by grant NSC 85-2332-B-037-066 from the National Scientific Council of the Republic of China. The Stockholm Case–control study was supported by grant from the Swedish National Cancer Society and from the Swedish Work Environment Fund. The New England bladder cancer study was funded in part by Grant Nos. 5 P42 ES007373 from the National Institute of Environmental Health Sciences, NIH and CA57494 from the National Cancer Institute, NIH. The Italian Case–control study on bladder cancer was conducted within the framework of the CNR (Italian National Research Council) Applied Project “Clinical Application of Oncological Research” (contracts: 94.01321.PF39 and 94.01119.PF39), and with the contributions of the Italian Association for Cancer Research, the Italian League against Tumours, Milan, and Mrs. Angela Marchegiano Borgomainerio. The Brescia bladder cancer study was partly supported by the International Agency for Research on Cancer. The French INSERM study was supported by a grant from the Direction G{\'e}n{\'e}rale de la Sant{\'e}, Minist{\`e}re des Affaires Sociales, France. The Molecular Epidemiology of Bladder Cancer and Prostate Cancer was supported in part by grants ES06718 (to Z.-F.Z.), U01 CA96116 (to A.B.), and CA09142 from the NIH National Institute of Environmental Health Sciences, the National Cancer Institute, the Department of Health and Human Services, and by the Ann Fitzpatrick Alper Program in Environmental Genomics at the Jonsson Comprehensive Cancer Centre, UCLA. Acknowledgments Funding Information: We gratefully acknowledge all principal investigators for their willingness to participate in this jointed project. The author E Y.W. YU gives thanks to the financial support from China Scholarship Council (No. 201706310135). Publisher Copyright: {\textcopyright} 2019, The Author(s).",
year = "2019",
month = aug,
doi = "10.1007/s10552-019-01191-1",
language = "English",
volume = "30",
pages = "859--870",
journal = "Cancer Causes & Control",
issn = "0957-5243",
publisher = "Springer",
number = "8",
}