The association between coffee consumption and bladder cancer in the bladder cancer epidemiology and nutritional determinants (BLEND) international pooled study

Evan Yi-Wen Yu*, Anke Wesselius, Frits van Osch, Mariana Carla Stern, Xuejuan Jiang, Eliane Kellen, Chih-Ming Lu, Hermann Pohlabeln, Gunnar Steineck, James Marshall, Mohamed Farouk Allam, Carlo La Vecchia, Kenneth C. Johnson, Simone Benhamou, Zuo-Feng Zhang, Cristina Bosetti, Jack A. Taylor, Maurice P. Zeegers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Web of Science)

Abstract

BackgroundInconsistent results for coffee consumption and bladder cancer (BC) risk have been shown in epidemiological studies. This research aims to increase the understanding of the association between coffee consumption and BC risk by bringing together worldwide case-control studies on this topic.MethodsData were collected from 13 case-control comprising of 5,911 cases and 16,172 controls. Pooled multivariate odds ratios (ORs), with corresponding 95% confidence intervals (CIs), were obtained using multilevel logistic regression models. Furthermore, linear dose-response relationships were examined using fractional polynomial models.ResultsNo association of BC risk was observed with coffee consumption among smokers. However, after adjustment for age, gender, and smoking, the risk was significantly increased for never smokers (ever vs. never coffee consumers: ORmodel2 1.30, 95% CI 1.06-1.59; heavy (>4 cups/day) coffee consumers vs. never coffee consumers: ORmodel2 1.52, 95% CI 1.18-1.97, p trend=0.23). In addition, dose-response analyses, in both the overall population and among never smokers, also showed a significant increased BC risk for coffee consumption of more than four cups per day. Among smokers, a significant increased BC risk was shown only after consumption of more than six cups per day.ConclusionThis research suggests that positive associations between coffee consumption and BC among never smokers but not smokers.

Original languageEnglish
Pages (from-to)859-870
Number of pages12
JournalCancer Causes & Control
Volume30
Issue number8
DOIs
Publication statusPublished - Aug 2019

Keywords

  • Bladder cancer
  • Coffee consumption
  • Smoking
  • Dose-response analyses
  • Population-attributable risk
  • TOBACCO SMOKING
  • RISK-FACTORS
  • RECALL BIAS
  • TEA CONSUMPTION
  • FLUID INTAKE
  • CAFFEINE
  • DRINKING
  • OCCUPATION
  • MORTALITY
  • ALCOHOL

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