The Association Between APOE epsilon 4 and Alzheimer-type Dementia Among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study

A. P. Vermeiren; H. Bosma; P.J. Visser; M.P. Zeegers; C. Graff; M. Ewers; G.B. Frisoni; L. Frolich; H. Hampel; R.W. Jones; P.G. Kehoe; H. Lenoir; L. Minthon; F.M. Nobili; M. Olde Rikkert; A.S. Rigaud; P. Scheltens; H. Soininen; L. Spiru; M. Tsolaki; L.O. Wahlund; B. Vellas; G. Wilcock; L.S. Elias-Sonnenschein; Frans Verhey

doi:10.3233/JAD-122182

The Association Between APOE epsilon 4 and Alzheimer-type Dementia Among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study

A. P. Vermeiren^*, H. Bosma, P.J. Visser, M.P. Zeegers, C. Graff, M. Ewers, G.B. Frisoni, L. Frolich, H. Hampel, R.W. Jones, P.G. Kehoe, H. Lenoir, L. Minthon, F.M. Nobili, M. Olde Rikkert, A.S. Rigaud, P. Scheltens, H. Soininen, L. Spiru, M. TsolakiL.O. Wahlund, B. Vellas, G. Wilcock, L.S. Elias-Sonnenschein, Frans Verhey

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We assessed the interaction between the APOE epsilon4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE epsilon4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-6.65, n = 222) and high (HR 3.67 95% CI 1.36-9.89, n = 139) but not in low educated subjects (HR 0.81, 95% CI 0.38-1.72, n = 183). This suggests that mechanisms in developing Alzheimer-type dementia may differ between educational groups that raises questions related to Alzheimer-type dementia prevention.

Original language	English
Pages (from-to)	241-246
Journal	Journal of Alzheimer's Disease
Volume	35
Issue number	2
DOIs	https://doi.org/10.3233/JAD-122182
Publication status	Published - 1 Jan 2013

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10.3233/JAD-122182

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Vermeiren, A. P., Bosma, H., Visser, P. J., Zeegers, M. P., Graff, C., Ewers, M., Frisoni, G. B., Frolich, L., Hampel, H., Jones, R. W., Kehoe, P. G., Lenoir, H., Minthon, L., Nobili, F. M., Olde Rikkert, M., Rigaud, A. S., Scheltens, P., Soininen, H., Spiru, L., ... Verhey, F. (2013). The Association Between APOE epsilon 4 and Alzheimer-type Dementia Among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study. Journal of Alzheimer's Disease, 35(2), 241-246. https://doi.org/10.3233/JAD-122182

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title = "The Association Between APOE epsilon 4 and Alzheimer-type Dementia Among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study",

abstract = "We assessed the interaction between the APOE epsilon4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE epsilon4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-6.65, n = 222) and high (HR 3.67 95% CI 1.36-9.89, n = 139) but not in low educated subjects (HR 0.81, 95% CI 0.38-1.72, n = 183). This suggests that mechanisms in developing Alzheimer-type dementia may differ between educational groups that raises questions related to Alzheimer-type dementia prevention.",

author = "Vermeiren, {A. P.} and H. Bosma and P.J. Visser and M.P. Zeegers and C. Graff and M. Ewers and G.B. Frisoni and L. Frolich and H. Hampel and R.W. Jones and P.G. Kehoe and H. Lenoir and L. Minthon and F.M. Nobili and {Olde Rikkert}, M. and A.S. Rigaud and P. Scheltens and H. Soininen and L. Spiru and M. Tsolaki and L.O. Wahlund and B. Vellas and G. Wilcock and L.S. Elias-Sonnenschein and Frans Verhey",

year = "2013",

month = jan,

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doi = "10.3233/JAD-122182",

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Vermeiren, AP, Bosma, H, Visser, PJ, Zeegers, MP, Graff, C, Ewers, M, Frisoni, GB, Frolich, L, Hampel, H, Jones, RW, Kehoe, PG, Lenoir, H, Minthon, L, Nobili, FM, Olde Rikkert, M, Rigaud, AS, Scheltens, P, Soininen, H, Spiru, L, Tsolaki, M, Wahlund, LO, Vellas, B, Wilcock, G, Elias-Sonnenschein, LS & Verhey, F 2013, 'The Association Between APOE epsilon 4 and Alzheimer-type Dementia Among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study', Journal of Alzheimer's Disease, vol. 35, no. 2, pp. 241-246. https://doi.org/10.3233/JAD-122182

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T1 - The Association Between APOE epsilon 4 and Alzheimer-type Dementia Among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study

AU - Vermeiren, A. P.

AU - Bosma, H.

AU - Visser, P.J.

AU - Zeegers, M.P.

AU - Graff, C.

AU - Ewers, M.

AU - Frisoni, G.B.

AU - Frolich, L.

AU - Hampel, H.

AU - Jones, R.W.

AU - Kehoe, P.G.

AU - Lenoir, H.

AU - Minthon, L.

AU - Nobili, F.M.

AU - Olde Rikkert, M.

AU - Rigaud, A.S.

AU - Scheltens, P.

AU - Soininen, H.

AU - Spiru, L.

AU - Tsolaki, M.

AU - Wahlund, L.O.

AU - Vellas, B.

AU - Wilcock, G.

AU - Elias-Sonnenschein, L.S.

AU - Verhey, Frans

PY - 2013/1/1

Y1 - 2013/1/1

N2 - We assessed the interaction between the APOE epsilon4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE epsilon4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-6.65, n = 222) and high (HR 3.67 95% CI 1.36-9.89, n = 139) but not in low educated subjects (HR 0.81, 95% CI 0.38-1.72, n = 183). This suggests that mechanisms in developing Alzheimer-type dementia may differ between educational groups that raises questions related to Alzheimer-type dementia prevention.

AB - We assessed the interaction between the APOE epsilon4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE epsilon4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-6.65, n = 222) and high (HR 3.67 95% CI 1.36-9.89, n = 139) but not in low educated subjects (HR 0.81, 95% CI 0.38-1.72, n = 183). This suggests that mechanisms in developing Alzheimer-type dementia may differ between educational groups that raises questions related to Alzheimer-type dementia prevention.

U2 - 10.3233/JAD-122182

DO - 10.3233/JAD-122182

M3 - Article

C2 - 23380990

SN - 1387-2877

VL - 35

SP - 241

EP - 246

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 2

ER -