The Association Between APOE epsilon 4 and Alzheimer-type Dementia Among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study

A. P. Vermeiren*, H. Bosma, P.J. Visser, M.P. Zeegers, C. Graff, M. Ewers, G.B. Frisoni, L. Frolich, H. Hampel, R.W. Jones, P.G. Kehoe, H. Lenoir, L. Minthon, F.M. Nobili, M. Olde Rikkert, A.S. Rigaud, P. Scheltens, H. Soininen, L. Spiru, M. TsolakiL.O. Wahlund, B. Vellas, G. Wilcock, L.S. Elias-Sonnenschein, Frans Verhey

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


We assessed the interaction between the APOE epsilon4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE epsilon4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-6.65, n = 222) and high (HR 3.67 95% CI 1.36-9.89, n = 139) but not in low educated subjects (HR 0.81, 95% CI 0.38-1.72, n = 183). This suggests that mechanisms in developing Alzheimer-type dementia may differ between educational groups that raises questions related to Alzheimer-type dementia prevention.
Original languageEnglish
Pages (from-to)241-246
JournalJournal of Alzheimer's Disease
Issue number2
Publication statusPublished - 1 Jan 2013

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