The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro

Jian Jiang*, Charlie D. Pieterman, Gokhan Ertaylan, Ralf L. M. Peeters, Theo M. C. M. de Kok

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Original languageEnglish
Pages (from-to)3067-3098
Number of pages32
JournalArchives of Toxicology
Volume93
Issue number11
DOIs
Publication statusPublished - 5 Oct 2019

Keywords

  • Drug-induced hepatotoxicity
  • In vitro human liver model
  • Omics approaches
  • Bioinformatics
  • Graphical Gaussian networks
  • Bayesian networks
  • PRIMARY HUMAN HEPATOCYTES
  • ON-A-CHIP
  • GENE-EXPRESSION PROFILES
  • PLURIPOTENT STEM-CELLS
  • 3D HUMAN LIVER
  • IPSC-DERIVED HEPATOCYTES
  • SET ENRICHMENT ANALYSIS
  • TIME-SERIES ANALYSIS
  • OXIDATIVE STRESS
  • HEPG2 CELLS

Cite this