The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro

Jian Jiang*, Charlie D. Pieterman, Gokhan Ertaylan, Ralf L. M. Peeters, Theo M. C. M. de Kok

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Original languageEnglish
Pages (from-to)3067-3098
Number of pages32
JournalArchives of Toxicology
Volume93
Issue number11
DOIs
Publication statusPublished - 5 Oct 2019

Keywords

  • Drug-induced hepatotoxicity
  • In vitro human liver model
  • Omics approaches
  • Bioinformatics
  • Graphical Gaussian networks
  • Bayesian networks
  • PRIMARY HUMAN HEPATOCYTES
  • ON-A-CHIP
  • GENE-EXPRESSION PROFILES
  • PLURIPOTENT STEM-CELLS
  • 3D HUMAN LIVER
  • IPSC-DERIVED HEPATOCYTES
  • SET ENRICHMENT ANALYSIS
  • TIME-SERIES ANALYSIS
  • OXIDATIVE STRESS
  • HEPG2 CELLS

Cite this

@article{ba95e5edaa1c416388a03be2ab60e433,
title = "The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro",
keywords = "Drug-induced hepatotoxicity, In vitro human liver model, Omics approaches, Bioinformatics, Graphical Gaussian networks, Bayesian networks, PRIMARY HUMAN HEPATOCYTES, ON-A-CHIP, GENE-EXPRESSION PROFILES, PLURIPOTENT STEM-CELLS, 3D HUMAN LIVER, IPSC-DERIVED HEPATOCYTES, SET ENRICHMENT ANALYSIS, TIME-SERIES ANALYSIS, OXIDATIVE STRESS, HEPG2 CELLS",
author = "Jian Jiang and Pieterman, {Charlie D.} and Gokhan Ertaylan and Peeters, {Ralf L. M.} and {de Kok}, {Theo M. C. M.}",
year = "2019",
month = "10",
day = "5",
doi = "10.1007/s00204-019-02585-5",
language = "English",
volume = "93",
pages = "3067--3098",
journal = "Archives of Toxicology",
issn = "0340-5761",
publisher = "Springer",
number = "11",

}

The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro. / Jiang, Jian; Pieterman, Charlie D.; Ertaylan, Gokhan; Peeters, Ralf L. M.; de Kok, Theo M. C. M.

In: Archives of Toxicology, Vol. 93, No. 11, 05.10.2019, p. 3067-3098.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro

AU - Jiang, Jian

AU - Pieterman, Charlie D.

AU - Ertaylan, Gokhan

AU - Peeters, Ralf L. M.

AU - de Kok, Theo M. C. M.

PY - 2019/10/5

Y1 - 2019/10/5

KW - Drug-induced hepatotoxicity

KW - In vitro human liver model

KW - Omics approaches

KW - Bioinformatics

KW - Graphical Gaussian networks

KW - Bayesian networks

KW - PRIMARY HUMAN HEPATOCYTES

KW - ON-A-CHIP

KW - GENE-EXPRESSION PROFILES

KW - PLURIPOTENT STEM-CELLS

KW - 3D HUMAN LIVER

KW - IPSC-DERIVED HEPATOCYTES

KW - SET ENRICHMENT ANALYSIS

KW - TIME-SERIES ANALYSIS

KW - OXIDATIVE STRESS

KW - HEPG2 CELLS

U2 - 10.1007/s00204-019-02585-5

DO - 10.1007/s00204-019-02585-5

M3 - Review article

VL - 93

SP - 3067

EP - 3098

JO - Archives of Toxicology

JF - Archives of Toxicology

SN - 0340-5761

IS - 11

ER -