The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures

Ravi S. Narayan, Carlos A. Fedrigo, Eelke Brands, Rogier Dik, Lukas J. A. Stalpers, Brigitta G. Baumert, Ben J. Slotman, Bart A. Westerman, Godefridus J. Peters, Peter Sminia*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number204
Number of pages8
JournalBMC Cancer
Volume17
DOIs
Publication statusPublished - 21 Mar 2017

Keywords

  • Glioma
  • Radiosensitization
  • Akt
  • Spheroid cultures
  • MK2206
  • Synergy
  • MALIGNANT GLIOMA
  • MICHAELIS-MENTEN
  • KINETIC SYSTEMS
  • SOLID TUMORS
  • MK-2206
  • PATHWAY
  • CELLS
  • AUTOPHAGY
  • CANCER
  • PROGRESSION

Cite this

Narayan, R. S., Fedrigo, C. A., Brands, E., Dik, R., Stalpers, L. J. A., Baumert, B. G., Slotman, B. J., Westerman, B. A., Peters, G. J., & Sminia, P. (2017). The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures. BMC Cancer, 17, [204]. https://doi.org/10.1186/s12885-017-3193-9