The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures

Ravi S. Narayan; Carlos A. Fedrigo; Eelke Brands; Rogier Dik; Lukas J. A. Stalpers; Brigitta G. Baumert; Ben J. Slotman; Bart A. Westerman; Godefridus J. Peters; Peter Sminia

doi:10.1186/s12885-017-3193-9

The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures

Ravi S. Narayan, Carlos A. Fedrigo, Eelke Brands, Rogier Dik, Lukas J. A. Stalpers, Brigitta G. Baumert, Ben J. Slotman, Bart A. Westerman, Godefridus J. Peters, Peter Sminia^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	204
Number of pages	8
Journal	BMC Cancer
Volume	17
DOIs	https://doi.org/10.1186/s12885-017-3193-9
Publication status	Published - 21 Mar 2017

Keywords

Glioma
Radiosensitization
Akt
Spheroid cultures
MK2206
Synergy
MALIGNANT GLIOMA
MICHAELIS-MENTEN
KINETIC SYSTEMS
SOLID TUMORS
MK-2206
PATHWAY
CELLS
AUTOPHAGY
CANCER
PROGRESSION

Access to Document

10.1186/s12885-017-3193-9

Cite this

Narayan, R. S., Fedrigo, C. A., Brands, E., Dik, R., Stalpers, L. J. A., Baumert, B. G., Slotman, B. J., Westerman, B. A., Peters, G. J., & Sminia, P. (2017). The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures. BMC Cancer, 17, [204]. https://doi.org/10.1186/s12885-017-3193-9

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title = "The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures",

keywords = "Glioma, Radiosensitization, Akt, Spheroid cultures, MK2206, Synergy, MALIGNANT GLIOMA, MICHAELIS-MENTEN, KINETIC SYSTEMS, SOLID TUMORS, MK-2206, PATHWAY, CELLS, AUTOPHAGY, CANCER, PROGRESSION",

author = "Narayan, {Ravi S.} and Fedrigo, {Carlos A.} and Eelke Brands and Rogier Dik and Stalpers, {Lukas J. A.} and Baumert, {Brigitta G.} and Slotman, {Ben J.} and Westerman, {Bart A.} and Peters, {Godefridus J.} and Peter Sminia",

year = "2017",

month = mar,

day = "21",

doi = "10.1186/s12885-017-3193-9",

language = "English",

volume = "17",

journal = "BMC Cancer",

issn = "1471-2407",

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The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures. / Narayan, Ravi S.; Fedrigo, Carlos A.; Brands, Eelke; Dik, Rogier; Stalpers, Lukas J. A.; Baumert, Brigitta G.; Slotman, Ben J.; Westerman, Bart A.; Peters, Godefridus J.; Sminia, Peter.

In: BMC Cancer, Vol. 17, 204, 21.03.2017.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures

AU - Narayan, Ravi S.

AU - Fedrigo, Carlos A.

AU - Brands, Eelke

AU - Dik, Rogier

AU - Stalpers, Lukas J. A.

AU - Baumert, Brigitta G.

AU - Slotman, Ben J.

AU - Westerman, Bart A.

AU - Peters, Godefridus J.

AU - Sminia, Peter

PY - 2017/3/21

Y1 - 2017/3/21

KW - Glioma

KW - Radiosensitization

KW - Akt

KW - Spheroid cultures

KW - MK2206

KW - Synergy

KW - MALIGNANT GLIOMA

KW - MICHAELIS-MENTEN

KW - KINETIC SYSTEMS

KW - SOLID TUMORS

KW - MK-2206

KW - PATHWAY

KW - CELLS

KW - AUTOPHAGY

KW - CANCER

KW - PROGRESSION

U2 - 10.1186/s12885-017-3193-9

DO - 10.1186/s12885-017-3193-9

M3 - Article

VL - 17

JO - BMC Cancer

JF - BMC Cancer

SN - 1471-2407

M1 - 204

ER -