The adenoma hunt in colorectal cancer screening: defining the target

Anke H. Sillars-Hardebol; Beatriz Carvalho; Manon van Engeland; Remond J. A. Fijneman; Gerrit A. Meijer

doi:10.1002/path.3012

The adenoma hunt in colorectal cancer screening: defining the target

Anke H. Sillars-Hardebol, Beatriz Carvalho, Manon van Engeland, Remond J. A. Fijneman, Gerrit A. Meijer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Colorectal adenomas are precursor lesions of colorectal cancer. Different biological and metabolic processes contribute to adenomagenesis. Subsequent progression to carcinoma occurs in only about 5% of the cases. Detection and removal of all adenomas would reduce CRC incidence and mortality, but at the cost of major over-treatment. Classical morphological characteristics fail to accurately discriminate between adenomas that will become malignant and those that will not. Understanding the biology of cancer development will help to better characterize adenomas at high risk of progression, and subsequently establish triage tests that allow to safely reserve colonoscopy only for individuals at high probability of having truly high-risk colorectal adenomas. Screening tests based on genomic changes that affect relevant biological and metabolic processes hold most promise in this respect. Pathological Society of Great Britain and Ireland. Published by

Original language	English
Pages (from-to)	1-6
Journal	Journal of Pathology
Volume	226
Issue number	1
DOIs	https://doi.org/10.1002/path.3012
Publication status	Published - Jan 2012

Keywords

colorectal cancer
adenoma
screening intermediate endpoint
tumour biology

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10.1002/path.3012

Cite this

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title = "The adenoma hunt in colorectal cancer screening: defining the target",

abstract = "Colorectal adenomas are precursor lesions of colorectal cancer. Different biological and metabolic processes contribute to adenomagenesis. Subsequent progression to carcinoma occurs in only about 5% of the cases. Detection and removal of all adenomas would reduce CRC incidence and mortality, but at the cost of major over-treatment. Classical morphological characteristics fail to accurately discriminate between adenomas that will become malignant and those that will not. Understanding the biology of cancer development will help to better characterize adenomas at high risk of progression, and subsequently establish triage tests that allow to safely reserve colonoscopy only for individuals at high probability of having truly high-risk colorectal adenomas. Screening tests based on genomic changes that affect relevant biological and metabolic processes hold most promise in this respect. Pathological Society of Great Britain and Ireland. Published by",

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AU - van Engeland, Manon

AU - Fijneman, Remond J. A.

AU - Meijer, Gerrit A.

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N2 - Colorectal adenomas are precursor lesions of colorectal cancer. Different biological and metabolic processes contribute to adenomagenesis. Subsequent progression to carcinoma occurs in only about 5% of the cases. Detection and removal of all adenomas would reduce CRC incidence and mortality, but at the cost of major over-treatment. Classical morphological characteristics fail to accurately discriminate between adenomas that will become malignant and those that will not. Understanding the biology of cancer development will help to better characterize adenomas at high risk of progression, and subsequently establish triage tests that allow to safely reserve colonoscopy only for individuals at high probability of having truly high-risk colorectal adenomas. Screening tests based on genomic changes that affect relevant biological and metabolic processes hold most promise in this respect. Pathological Society of Great Britain and Ireland. Published by

AB - Colorectal adenomas are precursor lesions of colorectal cancer. Different biological and metabolic processes contribute to adenomagenesis. Subsequent progression to carcinoma occurs in only about 5% of the cases. Detection and removal of all adenomas would reduce CRC incidence and mortality, but at the cost of major over-treatment. Classical morphological characteristics fail to accurately discriminate between adenomas that will become malignant and those that will not. Understanding the biology of cancer development will help to better characterize adenomas at high risk of progression, and subsequently establish triage tests that allow to safely reserve colonoscopy only for individuals at high probability of having truly high-risk colorectal adenomas. Screening tests based on genomic changes that affect relevant biological and metabolic processes hold most promise in this respect. Pathological Society of Great Britain and Ireland. Published by

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KW - screening intermediate endpoint

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