The accumulation of advanced glycation endproducts in diabetes and its relation to vascular disease

Marcelle G.A. van Eupen

Research output: ThesisDoctoral ThesisInternal

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Abstract

People with diabetes are at an increased risk of developing cardiovascular diseases. The aim of the studies described in this dissertation was to examine the role of advanced glycation endproducts (AGEs) in the development of cardiovascular diseases in people with and without diabetes. A clear, consistent relation was found between AGE accumulation in the skin and the extent of vascular damage. Therefore, a strong indication exists that AGEs are involved in the development of vascular damage in people with and without diabetes. This research project provides more insight into the mechanism underlying the relationship between diabetes and cardiovascular diseases. Hopefully, this information contributes to the development of new therapies to prevent and cure diabetes and subsequent vascular damage.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Schalkwijk, Casper, Supervisor
  • Stehouwer, Coen, Supervisor
Award date7 Sep 2017
Place of PublicationMaastricht
Publisher
Print ISBNs9789402807233
DOIs
Publication statusPublished - 2017

Keywords

  • diabetes
  • cardiovascular diseases
  • advanced glycation endproducts

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