Abstract
Background: Matrix Gla protein (MGP) is a natural inhibitor of tissue calcification. In a previous study, we observed the positive association between abnormal concentrations of uncarboxylatedMGP species and increased mortality risk in stable vascular patients. We explore whether co-incidence of abnormal status of uncarboxylated MPG and heart failure (HF) affects the mortality risk. Methods: We examined 799 patients (mean age 65.1 years) with stable vascular disease and followed them in a prospective study. Both, desphospho-uncarboxylated and total uncarboxylated MGP (dp-ucMGP or t-ucMGP) were quantified by pre-commercial ELISA assays. Results: Elevated (>100 ng/L) circulating brain natriuretic peptide (BNP) and abnormal status of plasma uncarboxylated MGP species (i.e.: dp-ucMGP >= 977 pmol/L or t-ucMGP
Original language | English |
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Pages (from-to) | 916-922 |
Journal | International Journal of Cardiology |
Volume | 203 |
DOIs | |
Publication status | Published - 15 Jan 2016 |
Keywords
- Matrix gamma-carboxyl glutamate protein (MGP)
- Heart failure
- dp-ucMGP
- t-ucMGP
- Mortality
- Atherovascular disease