The 2024 Assisi think tank on breast cancer: Focus on the use of a tumour bed boost after breast conserving therapy

Meritxell Arenas*, Yasemin Bölükbasi, Liesbeth J. Boersma, Birgitte Offersen, Vassilis Kouloulias, Isabella Palumbo, Lurdes Trigo, Laura Lozza, Fabio Marazzi, Marco Trovo, Sofia Rivera, Orit Kaidar-Person, Charlotte Coles, Icro Meattini, Vincenzo Valentini, Cynthia Aristei, Philip Poortmans, Assisi Think Tank Meeting (ATTM) 2024 members

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

At the Fifth Assisi Think Tank Meeting (ATTM) on breast cancer, one key topic was the role of tumor bed boost in invasive breast cancer and ductal carcinoma in situ. The need for a tumor bed boost after whole breast irradiation is controversial. A literature review assessed boost indications, target volume definition, techniques, dose fractionation, and ongoing trials. Findings indicated that while a boost halves the risk of local recurrence at 10 years, it also leads to worsened cosmetic outcomes and increased fibrosis without improving overall survival. Therefore, we would recommend to omit the boost if the estimated reduction in local recurrence at 10 years is less than 3 %, and to apply shared decision-making with patients, if the boost is expected to reduce the local recurrence rate with >3 % at 10 years. Future research will focus on identifying patient subgroups that can safely omit the boost and improving boost volume precision.
Original languageEnglish
Article number103881
Number of pages8
JournalBreast
Volume80
DOIs
Publication statusPublished - 1 Apr 2025

Keywords

  • Boost technique
  • Breast cancer
  • Dose fractionation
  • Local recurrence
  • Radiation therapy
  • Target volume definition
  • Tumour bed boost

Fingerprint

Dive into the research topics of 'The 2024 Assisi think tank on breast cancer: Focus on the use of a tumour bed boost after breast conserving therapy'. Together they form a unique fingerprint.

Cite this