The 2014 Updated GOLD Strategy: A Comparison of the Various Scenarios

S. Wilke, D.E. Smid, M.A. Spruit, D.J.A. Janssen, J.W.M. Muris, T. van der Molen, M. van den Akker, P.W. Jones, E.F.M. Wouters, F.M.E. Franssen

Research output: Contribution to journalArticleAcademicpeer-review


Background: The 2014 updated Global initiative for chronic Obstructive Lung Disease (GOLD) strategy added the St. George's Respiratory Questionnaire (SGRQ) as the fourth possible symptoms measure. The impact of the suggested tools for symptoms of COPD and the different definitions of future risk on the frequency distribution and clinical characteristics of the GOLD groups remain unknown. Methods: Demographic and clinical characteristics were assessed in 542 patients with COPD (57.7% male, age 64.6 [9.0] years, FEV1 54.7 [22.3]% predicted). Health status was assessed by the COPD-specific SGRQ and symptoms of anxiety and depression by the Hospital Anxiety and Depression Scale, anxiety (HADS-A) and depression (HADS-D) subscale. Cohen's Kappa was used to assess agreement between groups. Results: Level of agreement in frequency distribution using the modified Medical Research Council dyspnea (mMRC) scale ?2, COPD Assessment Test (CAT) ?10, Clinical COPD Questionnaire (CCQ) ?1 and SGRQ ?25 was moderate to very good. Best agreement was reached between CCQ and SGRQ (? = 0.838 or 0.851, p
Original languageEnglish
Pages (from-to)212-220
JournalChronic Obstructive Pulmonary Diseases : Journal of the COPD Foundation
Issue number2
Publication statusPublished - 1 Jan 2014

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