The β-D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men

Lukas Martin; Alexander Gombert; Jianmin Chen; Julia Liebens; Julia Verleger; Johannes Kalder; Gernot Marx; Michael Jacobs; Christoph Thiemermann; Tobias Schuerholz

doi:10.3389/fimmu.2017.00681

The β-_D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men

Lukas Martin, Alexander Gombert, Jianmin Chen, Julia Liebens, Julia Verleger, Johannes Kalder, Gernot Marx, Michael Jacobs, Christoph Thiemermann, Tobias Schuerholz

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	681
Number of pages	10
Journal	Frontiers in Immunology
Volume	8
DOIs	https://doi.org/10.3389/fimmu.2017.00681
Publication status	Published - 12 Jun 2017

Keywords

glycosaminoglycan
vascular surgery
syndecan-1
heparan sulfate
heparanase
perioperative care
ANTIMICROBIAL PEPTIDE 19-2.5
ENDOTHELIAL GLYCOCALYX
MAMMALIAN HEPARANASE
ORGAN DYSFUNCTION
LACTATE CLEARANCE
SEVERE SEPSIS
SEPTIC SHOCK
SURGERY
MORTALITY
ISCHEMIA

Cite this

Martin, L., Gombert, A., Chen, J., Liebens, J., Verleger, J., Kalder, J., Marx, G., Jacobs, M., Thiemermann, C., & Schuerholz, T. (2017). The β-_D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men. Frontiers in Immunology, 8, [681]. https://doi.org/10.3389/fimmu.2017.00681

Martin, Lukas ; Gombert, Alexander ; Chen, Jianmin ; Liebens, Julia ; Verleger, Julia ; Kalder, Johannes ; Marx, Gernot ; Jacobs, Michael ; Thiemermann, Christoph ; Schuerholz, Tobias. / The β-_D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair : Lessons Learnt from Mice and Men. In: Frontiers in Immunology. 2017 ; Vol. 8.

@article{710230e2cf70437590ccdca5df6f18a0,

title = "The β-D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men",

keywords = "glycosaminoglycan, vascular surgery, syndecan-1, heparan sulfate, heparanase, perioperative care, ANTIMICROBIAL PEPTIDE 19-2.5, ENDOTHELIAL GLYCOCALYX, MAMMALIAN HEPARANASE, ORGAN DYSFUNCTION, LACTATE CLEARANCE, SEVERE SEPSIS, SEPTIC SHOCK, SURGERY, MORTALITY, ISCHEMIA",

author = "Lukas Martin and Alexander Gombert and Jianmin Chen and Julia Liebens and Julia Verleger and Johannes Kalder and Gernot Marx and Michael Jacobs and Christoph Thiemermann and Tobias Schuerholz",

year = "2017",

month = jun

day = "12",

doi = "10.3389/fimmu.2017.00681",

language = "English",

volume = "8",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Media S.A.",

}

Martin, L, Gombert, A, Chen, J, Liebens, J, Verleger, J, Kalder, J, Marx, G, Jacobs, M, Thiemermann, C & Schuerholz, T 2017, 'The β-_D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men', Frontiers in Immunology, vol. 8, 681. https://doi.org/10.3389/fimmu.2017.00681

The β-_D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair : Lessons Learnt from Mice and Men. / Martin, Lukas; Gombert, Alexander; Chen, Jianmin; Liebens, Julia; Verleger, Julia; Kalder, Johannes; Marx, Gernot; Jacobs, Michael; Thiemermann, Christoph; Schuerholz, Tobias.

In: Frontiers in Immunology, Vol. 8, 681, 12.06.2017.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The β-D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair

T2 - Lessons Learnt from Mice and Men

AU - Martin, Lukas

AU - Gombert, Alexander

AU - Chen, Jianmin

AU - Liebens, Julia

AU - Verleger, Julia

AU - Kalder, Johannes

AU - Marx, Gernot

AU - Jacobs, Michael

AU - Thiemermann, Christoph

AU - Schuerholz, Tobias

PY - 2017/6/12

Y1 - 2017/6/12

KW - glycosaminoglycan

KW - vascular surgery

KW - syndecan-1

KW - heparan sulfate

KW - heparanase

KW - perioperative care

KW - ANTIMICROBIAL PEPTIDE 19-2.5

KW - ENDOTHELIAL GLYCOCALYX

KW - MAMMALIAN HEPARANASE

KW - ORGAN DYSFUNCTION

KW - LACTATE CLEARANCE

KW - SEVERE SEPSIS

KW - SEPTIC SHOCK

KW - SURGERY

KW - MORTALITY

KW - ISCHEMIA

U2 - 10.3389/fimmu.2017.00681

DO - 10.3389/fimmu.2017.00681

M3 - Article

VL - 8

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 681

ER -

Martin L, Gombert A, Chen J, Liebens J, Verleger J, Kalder J et al. The β-_D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men. Frontiers in Immunology. 2017 Jun 12;8. 681. https://doi.org/10.3389/fimmu.2017.00681

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10.3389/fimmu.2017.00681