The β-D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men

Lukas Martin, Alexander Gombert, Jianmin Chen, Julia Liebens, Julia Verleger, Johannes Kalder, Gernot Marx, Michael Jacobs, Christoph Thiemermann, Tobias Schuerholz

Research output: Contribution to journal › Article › Academic › peer-review

Original languageEnglish
Article number681
Number of pages10
JournalFrontiers in Immunology
Volume8
DOIs
Publication statusPublished - 12 Jun 2017

Keywords

  • glycosaminoglycan
  • vascular surgery
  • syndecan-1
  • heparan sulfate
  • heparanase
  • perioperative care
  • ANTIMICROBIAL PEPTIDE 19-2.5
  • ENDOTHELIAL GLYCOCALYX
  • MAMMALIAN HEPARANASE
  • ORGAN DYSFUNCTION
  • LACTATE CLEARANCE
  • SEVERE SEPSIS
  • SEPTIC SHOCK
  • SURGERY
  • MORTALITY
  • ISCHEMIA

Cite this

Martin, Lukas ; Gombert, Alexander ; Chen, Jianmin ; Liebens, Julia ; Verleger, Julia ; Kalder, Johannes ; Marx, Gernot ; Jacobs, Michael ; Thiemermann, Christoph ; Schuerholz, Tobias. / The β-D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair : Lessons Learnt from Mice and Men. In: Frontiers in Immunology. 2017 ; Vol. 8.
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title = "The β-D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men",
keywords = "glycosaminoglycan, vascular surgery, syndecan-1, heparan sulfate, heparanase, perioperative care, ANTIMICROBIAL PEPTIDE 19-2.5, ENDOTHELIAL GLYCOCALYX, MAMMALIAN HEPARANASE, ORGAN DYSFUNCTION, LACTATE CLEARANCE, SEVERE SEPSIS, SEPTIC SHOCK, SURGERY, MORTALITY, ISCHEMIA",
author = "Lukas Martin and Alexander Gombert and Jianmin Chen and Julia Liebens and Julia Verleger and Johannes Kalder and Gernot Marx and Michael Jacobs and Christoph Thiemermann and Tobias Schuerholz",
year = "2017",
month = "6",
day = "12",
doi = "10.3389/fimmu.2017.00681",
language = "English",
volume = "8",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S.A.",

}

Martin, L, Gombert, A, Chen, J, Liebens, J, Verleger, J, Kalder, J, Marx, G, Jacobs, M, Thiemermann, C & Schuerholz, T 2017, 'The β-D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men', Frontiers in Immunology, vol. 8, 681. https://doi.org/10.3389/fimmu.2017.00681

The β-D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair : Lessons Learnt from Mice and Men. / Martin, Lukas; Gombert, Alexander; Chen, Jianmin; Liebens, Julia; Verleger, Julia; Kalder, Johannes; Marx, Gernot; Jacobs, Michael; Thiemermann, Christoph; Schuerholz, Tobias.

In: Frontiers in Immunology, Vol. 8, 681, 12.06.2017.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The β-D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair

T2 - Lessons Learnt from Mice and Men

AU - Martin, Lukas

AU - Gombert, Alexander

AU - Chen, Jianmin

AU - Liebens, Julia

AU - Verleger, Julia

AU - Kalder, Johannes

AU - Marx, Gernot

AU - Jacobs, Michael

AU - Thiemermann, Christoph

AU - Schuerholz, Tobias

PY - 2017/6/12

Y1 - 2017/6/12

KW - glycosaminoglycan

KW - vascular surgery

KW - syndecan-1

KW - heparan sulfate

KW - heparanase

KW - perioperative care

KW - ANTIMICROBIAL PEPTIDE 19-2.5

KW - ENDOTHELIAL GLYCOCALYX

KW - MAMMALIAN HEPARANASE

KW - ORGAN DYSFUNCTION

KW - LACTATE CLEARANCE

KW - SEVERE SEPSIS

KW - SEPTIC SHOCK

KW - SURGERY

KW - MORTALITY

KW - ISCHEMIA

U2 - 10.3389/fimmu.2017.00681

DO - 10.3389/fimmu.2017.00681

M3 - Article

VL - 8

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 681

ER -

Martin L, Gombert A, Chen J, Liebens J, Verleger J, Kalder J et al. The β-D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men. Frontiers in Immunology. 2017 Jun 12;8. 681. https://doi.org/10.3389/fimmu.2017.00681

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