The β-D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men

Lukas Martin, Alexander Gombert, Jianmin Chen, Julia Liebens, Julia Verleger, Johannes Kalder, Gernot Marx, Michael Jacobs, Christoph Thiemermann, Tobias Schuerholz

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number681
Number of pages10
JournalFrontiers in Immunology
Volume8
DOIs
Publication statusPublished - 12 Jun 2017

Keywords

  • glycosaminoglycan
  • vascular surgery
  • syndecan-1
  • heparan sulfate
  • heparanase
  • perioperative care
  • ANTIMICROBIAL PEPTIDE 19-2.5
  • ENDOTHELIAL GLYCOCALYX
  • MAMMALIAN HEPARANASE
  • ORGAN DYSFUNCTION
  • LACTATE CLEARANCE
  • SEVERE SEPSIS
  • SEPTIC SHOCK
  • SURGERY
  • MORTALITY
  • ISCHEMIA

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