The β-D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men

Lukas Martin; Alexander Gombert; Jianmin Chen; Julia Liebens; Julia Verleger; Johannes Kalder; Gernot Marx; Michael Jacobs; Christoph Thiemermann; Tobias Schuerholz

doi:10.3389/fimmu.2017.00681

The β-_D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men

Lukas Martin, Alexander Gombert, Jianmin Chen, Julia Liebens, Julia Verleger, Johannes Kalder, Gernot Marx, Michael Jacobs, Christoph Thiemermann, Tobias Schuerholz

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	681
Number of pages	10
Journal	Frontiers in Immunology
Volume	8
DOIs	https://doi.org/10.3389/fimmu.2017.00681
Publication status	Published - 12 Jun 2017

Keywords

glycosaminoglycan
vascular surgery
syndecan-1
heparan sulfate
heparanase
perioperative care
ANTIMICROBIAL PEPTIDE 19-2.5
ENDOTHELIAL GLYCOCALYX
MAMMALIAN HEPARANASE
ORGAN DYSFUNCTION
LACTATE CLEARANCE
SEVERE SEPSIS
SEPTIC SHOCK
SURGERY
MORTALITY
ISCHEMIA

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10.3389/fimmu.2017.00681

Cite this

Martin, L., Gombert, A., Chen, J., Liebens, J., Verleger, J., Kalder, J., Marx, G., Jacobs, M., Thiemermann, C., & Schuerholz, T. (2017). The β-_D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men. Frontiers in Immunology, 8, [681]. https://doi.org/10.3389/fimmu.2017.00681

Martin, Lukas ; Gombert, Alexander ; Chen, Jianmin ; Liebens, Julia ; Verleger, Julia ; Kalder, Johannes ; Marx, Gernot ; Jacobs, Michael ; Thiemermann, Christoph ; Schuerholz, Tobias. / The β-_D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair : Lessons Learnt from Mice and Men. In: Frontiers in Immunology. 2017 ; Vol. 8.

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title = "The β-D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men",

keywords = "glycosaminoglycan, vascular surgery, syndecan-1, heparan sulfate, heparanase, perioperative care, ANTIMICROBIAL PEPTIDE 19-2.5, ENDOTHELIAL GLYCOCALYX, MAMMALIAN HEPARANASE, ORGAN DYSFUNCTION, LACTATE CLEARANCE, SEVERE SEPSIS, SEPTIC SHOCK, SURGERY, MORTALITY, ISCHEMIA",

author = "Lukas Martin and Alexander Gombert and Jianmin Chen and Julia Liebens and Julia Verleger and Johannes Kalder and Gernot Marx and Michael Jacobs and Christoph Thiemermann and Tobias Schuerholz",

year = "2017",

month = jun,

day = "12",

doi = "10.3389/fimmu.2017.00681",

language = "English",

volume = "8",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Media S.A.",

}

Martin, L, Gombert, A, Chen, J, Liebens, J, Verleger, J, Kalder, J, Marx, G, Jacobs, M, Thiemermann, C & Schuerholz, T 2017, 'The β-_D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men', Frontiers in Immunology, vol. 8, 681. https://doi.org/10.3389/fimmu.2017.00681

The β-_D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair : Lessons Learnt from Mice and Men. / Martin, Lukas; Gombert, Alexander; Chen, Jianmin; Liebens, Julia; Verleger, Julia; Kalder, Johannes; Marx, Gernot; Jacobs, Michael; Thiemermann, Christoph; Schuerholz, Tobias.

In: Frontiers in Immunology, Vol. 8, 681, 12.06.2017.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The β-D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair

T2 - Lessons Learnt from Mice and Men

AU - Martin, Lukas

AU - Gombert, Alexander

AU - Chen, Jianmin

AU - Liebens, Julia

AU - Verleger, Julia

AU - Kalder, Johannes

AU - Marx, Gernot

AU - Jacobs, Michael

AU - Thiemermann, Christoph

AU - Schuerholz, Tobias

PY - 2017/6/12

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KW - glycosaminoglycan

KW - vascular surgery

KW - syndecan-1

KW - heparan sulfate

KW - heparanase

KW - perioperative care

KW - ANTIMICROBIAL PEPTIDE 19-2.5

KW - ENDOTHELIAL GLYCOCALYX

KW - MAMMALIAN HEPARANASE

KW - ORGAN DYSFUNCTION

KW - LACTATE CLEARANCE

KW - SEVERE SEPSIS

KW - SEPTIC SHOCK

KW - SURGERY

KW - MORTALITY

KW - ISCHEMIA

U2 - 10.3389/fimmu.2017.00681

DO - 10.3389/fimmu.2017.00681

M3 - Article

VL - 8

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 681

ER -

Martin L, Gombert A, Chen J, Liebens J, Verleger J, Kalder J et al. The β-_D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men. Frontiers in Immunology. 2017 Jun 12;8. 681. https://doi.org/10.3389/fimmu.2017.00681