Abstract
AIM: To investigate the merits of texture analysis on parametric maps derived from pharmacokinetic modeling with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as imaging biomarkers for the prediction of treatment response in patients with head and neck squamous cell carcinoma (HNSCC).
METHODS: In this retrospective study, 19 HNSCC patients underwent pre- and intra-treatment DCE-MRI scans at a 1.5T MRI scanner. All patients had chemo-radiation treatment. Pharmacokinetic modeling was performed on the acquired DCE-MRI images, generating maps of volume transfer rate (K-trans) and volume fraction of the extravascular extracellular space (v(e)). Image texture analysis was then employed on maps of K-trans and v(e), generating two texture measures: Energy (E) and homogeneity.
RESULTS: No significant changes were found for the mean and standard deviation for K-trans and v(e) between pre- and intra-treatment (P > 0.09). Texture analysis revealed that the imaging biomarker E of v(e) was significantly higher in intra-treatment scans, relative to pretreatment scans (P <0.04).
CONCLUSION: Chemo-radiation treatment in HNSCC significantly reduces the heterogeneity of tumors.
Original language | English |
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Pages (from-to) | 90-97 |
Number of pages | 8 |
Journal | World Journal of Radiology |
Volume | 8 |
Issue number | 1 |
DOIs | |
Publication status | Published - 28 Jan 2016 |
Keywords
- Tumor heterogeneity
- Dynamic contrast-enhanced magnetic resonance imaging
- Image texture analysis
- Head and neck squamous cell carcinomas