Testing relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents

Linn B. Norbom, Jaroslav Rokicki, Dennis van der Meer, Dag Alnaes, Nhat Trung Doan, Torgeir Moberget, Tobias Kaufmann, Ole A. Andreassen, Lars T. Westlye, Christian K. Tamnes*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Human brain development involves spatially and temporally heterogeneous changes, detectable across a wide range of magnetic resonance imaging (MRI) measures. Investigating the interplay between multimodal MRI and polygenic scores (PGS) for personality traits associated with mental disorders in youth may provide new knowledge about typical and atypical neurodevelopment. We derived independent components across cortical thickness, cortical surface area, and grey/white matter contrast (GWC) (n=2596, 3-23 years), and tested for associations between these components and age, sex and-, in a subsample (n=878), PGS for neuroticism. Age was negatively associated with a single-modality component reflecting higher global GWC, and additionally with components capturing common variance between global thickness and GWC, and several multimodal regional patterns. Sex differences were found for components primarily capturing global and regional surface area (boys>girls), but also regional cortical thickness. For PGS for neuroticism, we found weak and bidirectional associations with a component reflecting right prefrontal surface area. These results indicate that multimodal fusion is sensitive to age and sex differences in brain structure in youth, but only weakly to polygenic load for neuroticism.

Original languageEnglish
Article number251
Number of pages10
JournalTranslational Psychiatry
Volume10
Issue number1
DOIs
Publication statusPublished - 24 Jul 2020

Keywords

  • SURFACE-BASED ANALYSIS
  • CORTICAL THICKNESS
  • LONGITUDINAL CHANGES
  • PUBERTAL CHANGES
  • MATTER CONTRAST
  • CEREBRAL-CORTEX
  • WHITE
  • GRAY
  • AREA
  • MRI

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