Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects

Luisa Klotz; Melanie Eschborn; Maren Lindner; Marie Liebmann; Martin Herold; Claudia Janoschka; Belen Torres Garrido; Andreas Schulte-Mecklenbeck; Catharina C. Gross; Johanna Breuer; Petra Hundehege; Vilmos Posevitz; Beatrice Pignolet; Giulia Nebel; Shirin Glander; Nicole Freise; Judith Austermann; Timo Wirth; Graham R. Campbell; Tilman Schneider-Hohendorf; Maria Eveslage; David Brassat; Nicholas Schwab; Karin Loser; Johannes Roth; Karin B. Busch; Monika Stoll; Don J. Mahad; Sven G. Meuth; Timothy Turner; Amit Bar-Or; Heinz Wiendl

doi:10.1126/scitranslmed.aao5563

Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects

Luisa Klotz^*, Melanie Eschborn, Maren Lindner, Marie Liebmann, Martin Herold, Claudia Janoschka, Belen Torres Garrido, Andreas Schulte-Mecklenbeck, Catharina C. Gross, Johanna Breuer, Petra Hundehege, Vilmos Posevitz, Beatrice Pignolet, Giulia Nebel, Shirin Glander, Nicole Freise, Judith Austermann, Timo Wirth, Graham R. Campbell, Tilman Schneider-HohendorfMaria Eveslage, David Brassat, Nicholas Schwab, Karin Loser, Johannes Roth, Karin B. Busch, Monika Stoll, Don J. Mahad, Sven G. Meuth, Timothy Turner, Amit Bar-Or, Heinz Wiendl

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	5563
Number of pages	17
Journal	Science Translational Medicine
Volume	11
Issue number	490
DOIs	https://doi.org/10.1126/scitranslmed.aao5563
Publication status	Published - 1 May 2019

Keywords

RHEUMATOID-ARTHRITIS
NEGATIVE SELECTION
AVIDITY MATURATION
LEFLUNOMIDE
TCR

Access to Document

10.1126/scitranslmed.aao5563

Cite this

Klotz, L., Eschborn, M., Lindner, M., Liebmann, M., Herold, M., Janoschka, C., Garrido, B. T., Schulte-Mecklenbeck, A., Gross, C. C., Breuer, J., Hundehege, P., Posevitz, V., Pignolet, B., Nebel, G., Glander, S., Freise, N., Austermann, J., Wirth, T., Campbell, G. R., ... Wiendl, H. (2019). Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects. Science Translational Medicine, 11(490), [5563]. https://doi.org/10.1126/scitranslmed.aao5563

Klotz, Luisa ; Eschborn, Melanie ; Lindner, Maren ; Liebmann, Marie ; Herold, Martin ; Janoschka, Claudia ; Garrido, Belen Torres ; Schulte-Mecklenbeck, Andreas ; Gross, Catharina C. ; Breuer, Johanna ; Hundehege, Petra ; Posevitz, Vilmos ; Pignolet, Beatrice ; Nebel, Giulia ; Glander, Shirin ; Freise, Nicole ; Austermann, Judith ; Wirth, Timo ; Campbell, Graham R. ; Schneider-Hohendorf, Tilman ; Eveslage, Maria ; Brassat, David ; Schwab, Nicholas ; Loser, Karin ; Roth, Johannes ; Busch, Karin B. ; Stoll, Monika ; Mahad, Don J. ; Meuth, Sven G. ; Turner, Timothy ; Bar-Or, Amit ; Wiendl, Heinz. / Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects. In: Science Translational Medicine. 2019 ; Vol. 11, No. 490.

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title = "Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects",

keywords = "RHEUMATOID-ARTHRITIS, NEGATIVE SELECTION, AVIDITY MATURATION, LEFLUNOMIDE, TCR",

author = "Luisa Klotz and Melanie Eschborn and Maren Lindner and Marie Liebmann and Martin Herold and Claudia Janoschka and Garrido, {Belen Torres} and Andreas Schulte-Mecklenbeck and Gross, {Catharina C.} and Johanna Breuer and Petra Hundehege and Vilmos Posevitz and Beatrice Pignolet and Giulia Nebel and Shirin Glander and Nicole Freise and Judith Austermann and Timo Wirth and Campbell, {Graham R.} and Tilman Schneider-Hohendorf and Maria Eveslage and David Brassat and Nicholas Schwab and Karin Loser and Johannes Roth and Busch, {Karin B.} and Monika Stoll and Mahad, {Don J.} and Meuth, {Sven G.} and Timothy Turner and Amit Bar-Or and Heinz Wiendl",

year = "2019",

month = may,

day = "1",

doi = "10.1126/scitranslmed.aao5563",

language = "English",

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issn = "1946-6234",

publisher = "American Association for the Advancement of Science",

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Klotz, L, Eschborn, M, Lindner, M, Liebmann, M, Herold, M, Janoschka, C, Garrido, BT, Schulte-Mecklenbeck, A, Gross, CC, Breuer, J, Hundehege, P, Posevitz, V, Pignolet, B, Nebel, G, Glander, S, Freise, N, Austermann, J, Wirth, T, Campbell, GR, Schneider-Hohendorf, T, Eveslage, M, Brassat, D, Schwab, N, Loser, K, Roth, J, Busch, KB, Stoll, M, Mahad, DJ, Meuth, SG, Turner, T, Bar-Or, A & Wiendl, H 2019, 'Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects', Science Translational Medicine, vol. 11, no. 490, 5563. https://doi.org/10.1126/scitranslmed.aao5563

Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects. / Klotz, Luisa; Eschborn, Melanie; Lindner, Maren; Liebmann, Marie; Herold, Martin; Janoschka, Claudia; Garrido, Belen Torres; Schulte-Mecklenbeck, Andreas; Gross, Catharina C.; Breuer, Johanna; Hundehege, Petra; Posevitz, Vilmos; Pignolet, Beatrice; Nebel, Giulia; Glander, Shirin; Freise, Nicole; Austermann, Judith; Wirth, Timo; Campbell, Graham R.; Schneider-Hohendorf, Tilman; Eveslage, Maria; Brassat, David; Schwab, Nicholas; Loser, Karin; Roth, Johannes; Busch, Karin B.; Stoll, Monika; Mahad, Don J.; Meuth, Sven G.; Turner, Timothy; Bar-Or, Amit; Wiendl, Heinz.

In: Science Translational Medicine, Vol. 11, No. 490, 5563, 01.05.2019.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects

AU - Klotz, Luisa

AU - Eschborn, Melanie

AU - Lindner, Maren

AU - Liebmann, Marie

AU - Herold, Martin

AU - Janoschka, Claudia

AU - Garrido, Belen Torres

AU - Schulte-Mecklenbeck, Andreas

AU - Gross, Catharina C.

AU - Breuer, Johanna

AU - Hundehege, Petra

AU - Posevitz, Vilmos

AU - Pignolet, Beatrice

AU - Nebel, Giulia

AU - Glander, Shirin

AU - Freise, Nicole

AU - Austermann, Judith

AU - Wirth, Timo

AU - Campbell, Graham R.

AU - Schneider-Hohendorf, Tilman

AU - Eveslage, Maria

AU - Brassat, David

AU - Schwab, Nicholas

AU - Loser, Karin

AU - Roth, Johannes

AU - Busch, Karin B.

AU - Stoll, Monika

AU - Mahad, Don J.

AU - Meuth, Sven G.

AU - Turner, Timothy

AU - Bar-Or, Amit

AU - Wiendl, Heinz

PY - 2019/5/1

Y1 - 2019/5/1

KW - RHEUMATOID-ARTHRITIS

KW - NEGATIVE SELECTION

KW - AVIDITY MATURATION

KW - LEFLUNOMIDE

KW - TCR

U2 - 10.1126/scitranslmed.aao5563

DO - 10.1126/scitranslmed.aao5563

M3 - Article

C2 - 31043571

VL - 11

JO - Science Translational Medicine

JF - Science Translational Medicine

SN - 1946-6234

IS - 490

M1 - 5563

ER -