Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects

Luisa Klotz*, Melanie Eschborn, Maren Lindner, Marie Liebmann, Martin Herold, Claudia Janoschka, Belen Torres Garrido, Andreas Schulte-Mecklenbeck, Catharina C. Gross, Johanna Breuer, Petra Hundehege, Vilmos Posevitz, Beatrice Pignolet, Giulia Nebel, Shirin Glander, Nicole Freise, Judith Austermann, Timo Wirth, Graham R. Campbell, Tilman Schneider-HohendorfMaria Eveslage, David Brassat, Nicholas Schwab, Karin Loser, Johannes Roth, Karin B. Busch, Monika Stoll, Don J. Mahad, Sven G. Meuth, Timothy Turner, Amit Bar-Or, Heinz Wiendl

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number5563
Number of pages17
JournalScience Translational Medicine
Volume11
Issue number490
DOIs
Publication statusPublished - 1 May 2019

Keywords

  • RHEUMATOID-ARTHRITIS
  • NEGATIVE SELECTION
  • AVIDITY MATURATION
  • LEFLUNOMIDE
  • TCR

Cite this

Klotz, L., Eschborn, M., Lindner, M., Liebmann, M., Herold, M., Janoschka, C., Garrido, B. T., Schulte-Mecklenbeck, A., Gross, C. C., Breuer, J., Hundehege, P., Posevitz, V., Pignolet, B., Nebel, G., Glander, S., Freise, N., Austermann, J., Wirth, T., Campbell, G. R., ... Wiendl, H. (2019). Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects. Science Translational Medicine, 11(490), [5563]. https://doi.org/10.1126/scitranslmed.aao5563