Ten-Year Outcomes of First-Episode Psychoses in the MRC AESOP-10 Study

Camice J. Revier; Ulrich Reininghaus; Rina Dutta; Paul Fearon; Robin M. Murray; Gillian A. Doody; Tim Croudace; Paola Dazzan; Margaret Heslin; Adanna Onyejiaka; Eugenia Kravariti; Julia Lappin; Ben Lomas; James B. Kirkbride; Kim Donoghue; Craig Morgan; Peter B. Jones

doi:10.1097/NMD.0000000000000295

Ten-Year Outcomes of First-Episode Psychoses in the MRC AESOP-10 Study

Camice J. Revier^*, Ulrich Reininghaus, Rina Dutta, Paul Fearon, Robin M. Murray, Gillian A. Doody, Tim Croudace, Paola Dazzan, Margaret Heslin, Adanna Onyejiaka, Eugenia Kravariti, Julia Lappin, Ben Lomas, James B. Kirkbride, Kim Donoghue, Craig Morgan, Peter B. Jones

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the AESOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.

Original language	English
Pages (from-to)	379-386
Journal	Journal of Nervous and Mental Disease
Volume	203
Issue number	5
DOIs	https://doi.org/10.1097/NMD.0000000000000295
Publication status	Published - May 2015

Keywords

Schizophrenia
psychosis
recovery
course and outcome
risk factors

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10.1097/NMD.0000000000000295Licence: Unspecified

Cite this

Revier, C. J., Reininghaus, U., Dutta, R., Fearon, P., Murray, R. M., Doody, G. A., Croudace, T., Dazzan, P., Heslin, M., Onyejiaka, A., Kravariti, E., Lappin, J., Lomas, B., Kirkbride, J. B., Donoghue, K., Morgan, C., & Jones, P. B. (2015). Ten-Year Outcomes of First-Episode Psychoses in the MRC AESOP-10 Study. Journal of Nervous and Mental Disease, 203(5), 379-386. https://doi.org/10.1097/NMD.0000000000000295

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title = "Ten-Year Outcomes of First-Episode Psychoses in the MRC AESOP-10 Study",

abstract = "It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the AESOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.",

keywords = "Schizophrenia, psychosis, recovery, course and outcome, risk factors",

author = "Revier, {Camice J.} and Ulrich Reininghaus and Rina Dutta and Paul Fearon and Murray, {Robin M.} and Doody, {Gillian A.} and Tim Croudace and Paola Dazzan and Margaret Heslin and Adanna Onyejiaka and Eugenia Kravariti and Julia Lappin and Ben Lomas and Kirkbride, {James B.} and Kim Donoghue and Craig Morgan and Jones, {Peter B.}",

year = "2015",

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doi = "10.1097/NMD.0000000000000295",

language = "English",

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pages = "379--386",

journal = "Journal of Nervous and Mental Disease",

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Revier, CJ, Reininghaus, U, Dutta, R, Fearon, P, Murray, RM, Doody, GA, Croudace, T, Dazzan, P, Heslin, M, Onyejiaka, A, Kravariti, E, Lappin, J, Lomas, B, Kirkbride, JB, Donoghue, K, Morgan, C & Jones, PB 2015, 'Ten-Year Outcomes of First-Episode Psychoses in the MRC AESOP-10 Study', Journal of Nervous and Mental Disease, vol. 203, no. 5, pp. 379-386. https://doi.org/10.1097/NMD.0000000000000295

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AU - Revier, Camice J.

AU - Reininghaus, Ulrich

AU - Dutta, Rina

AU - Fearon, Paul

AU - Murray, Robin M.

AU - Doody, Gillian A.

AU - Croudace, Tim

AU - Dazzan, Paola

AU - Heslin, Margaret

AU - Onyejiaka, Adanna

AU - Kravariti, Eugenia

AU - Lappin, Julia

AU - Lomas, Ben

AU - Kirkbride, James B.

AU - Donoghue, Kim

AU - Morgan, Craig

AU - Jones, Peter B.

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