Ten steps to investigate a cellular system with mathematical modeling

Jasia King, Kerbai Said Eroume, Roman Truckenmuller, Stefan Giselbrecht, Ann E. Cowan, Leslie Loew, Aurelie Carlier*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Cellular and intracellular processes are inherently complex due to the large number of components and interactions, which are often nonlinear and occur at different spatiotemporal scales. Because of this complexity, mathematical modeling is increasingly used to simulate such systems and perform experiments in silico, many orders of magnitude faster than real experiments and often at a higher spatiotemporal resolution. In this article, we will focus on the generic modeling process and illustrate it with an example model of membrane lipid turnover.

Original languageEnglish
Article number1008921
Number of pages8
JournalPLoS Computational Biology
Issue number5
Publication statusPublished - May 2021


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