Temporo-cerebellar connectivity underlies timing constraints in audition

Anika Stockert, Michael Schwartze, David Poeppel, Alfred Anwander, Sonja Kotz*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

The flexible and efficient adaptation to dynamic, rapid changes in the auditory environment likely involves generating and updating of internal models. Such models arguably exploit connections between the neocortex and the cerebellum, supporting proactive adaptation. Here we tested whether temporo-cerebellar disconnection is associated with the processing of sound at short-timescales. First, we identify lesion-specific deficits for the encoding of short timescale spectro-temporal non-speech and speech properties in patients with left posterior temporal cortex stroke. Second, using lesion- guided probabilistic tractography in healthy participants, we revealed bidirectional temporo-cerebellar connectivity with cerebellar dentate nuclei and crura I/II. These findings support the view that the encoding and modeling of rapidly modulated auditory spectro-temporal properties can rely on a temporo-cerebellar interface. We discuss these findings in view of the conjecture that proactive adaptation to a dynamic environment via internal models is a generalizable principle.

Original languageEnglish
Article numbere67303
Number of pages23
JournalElife
Volume10
Early online date20 Sep 2021
DOIs
Publication statusPublished - 20 Sep 2021

Keywords

  • Human
  • IN-VIVO
  • MIDDLE LONGITUDINAL FASCICLE
  • MOTOR
  • PERCEPTION
  • PROJECTIONS
  • RHESUS-MONKEY
  • SPEECH
  • SYSTEM
  • TRACTOGRAPHY
  • WHITE-MATTER
  • audition
  • internal models
  • lateralization
  • lesion mapping
  • temporo-cerebellar connectivity
  • tractography

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