Temporal Evolution of Poststroke Cognitive Impairment Using the Montreal Cognitive Assessment

Britta Nijsse, Johanna M A Visser-Meily, Maria L van Mierlo, Marcel W M Post, Paul L M de Kort, Caroline M van Heugten

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND AND PURPOSE: The Montreal Cognitive Assessment (MoCA) is nowadays recommended for the screening of poststroke cognitive impairment. However, little is known about the temporal evolution of MoCA-assessed cognition after stroke. The objective of this study was to examine the temporal pattern of overall and domain-specific cognition at 2 and 6 months after stroke using the MoCA and to identify patient groups at risk for cognitive impairment at 6 months after stroke.

METHODS: Prospective cohort study in which 324 patients were administered the MoCA at 2 and 6 months post stroke. Cognitive impairment was defined as MoCA<26. Differences in cognitive impairment rates between 2 and 6 months post stroke were analyzed in different subgroups. Patients with MoCA score <26 at 2 months, who improved by ≥2 points by 6 months, were defined as reverters. Logistic regression analyses were used to identify determinants of (1) cognitive impairment at 6 months post stroke and (2) reverter status.

RESULTS: Between 2 and 6 months post stroke, mean MoCA score improved from 23.7 (3.9) to 24.7 (3.5), P<0.001. Prevalence of cognitive impairment at 2 months was 66.4%, compared with 51.9% at 6 months (P<0.001). More comorbidity and presence of cognitive impairment at 2 months were significant independent predictors of cognitive impairment 6 months post stroke. No significant determinants of reverter status were identified.

CONCLUSIONS: Although cognitive improvement is seen ≤6 months post stroke, long-term cognitive deficits are prevalent. Identifying patients at risk of cognitive impairment is, therefore, important as well as targeting interventions to this group.

Original languageEnglish
Pages (from-to)98-104
Number of pages7
JournalStroke
Volume48
Issue number1
DOIs
Publication statusPublished - Jan 2017

Keywords

  • cognitive impairment
  • stroke
  • MINI-MENTAL-STATE
  • TRANSIENT ISCHEMIC ATTACK
  • STROKE
  • INSTRUMENTS
  • PREDICTORS
  • RECOVERY
  • DISEASE

Cite this

Nijsse, B., Visser-Meily, J. M. A., van Mierlo, M. L., Post, M. W. M., de Kort, P. L. M., & van Heugten, C. M. (2017). Temporal Evolution of Poststroke Cognitive Impairment Using the Montreal Cognitive Assessment. Stroke, 48(1), 98-104. https://doi.org/10.1161/STROKEAHA.116.014168