Temporal Evolution of Cognitive Changes in Incident Hypertension Prospective Cohort Study Across the Adult Age Span

Sebastian Kohler; Maria A. E. Baars; Peggy Spauwen; Syenna Schievink; Frans R. J. Verhey; Martin J. P. van Boxtel

doi:10.1161/HYPERTENSIONAHA.113.02096

Temporal Evolution of Cognitive Changes in Incident Hypertension Prospective Cohort Study Across the Adult Age Span

Sebastian Kohler^*, Maria A. E. Baars, Peggy Spauwen, Syenna Schievink, Frans R. J. Verhey, Martin J. P. van Boxtel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Midlife hypertension is a risk factor for dementia, but little is known about the cognitive trajectories of individuals with incident hypertension. This study follows the cognitive functioning in prevalent and incident hypertension for 12 years and in relation to age and treatment status. Cognitively intact adults aged 25 to 84 years (n=1805) were serially assessed at baseline, 6 years, and 12 years. Hypertension was defined by sphygmomanometry or antihypertensive medication use, and its association with cognitive decline was tested in random-effects models. At baseline, 638 (35.3%) participants had hypertension. They showed faster decline in memory (chi(2) test for homogeneity=35.75; df=2; P

Original language	English
Pages (from-to)	245–251
Journal	Hypertension
Volume	63
Issue number	2
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.113.02096
Publication status	Published - Feb 2014

Keywords

cognition
cohort studies
dementia
epidemiology
neuropsychology

Access to Document

10.1161/HYPERTENSIONAHA.113.02096

Cite this

@article{4acecd3d41b64e94af3e0ee7fb38eeeb,

title = "Temporal Evolution of Cognitive Changes in Incident Hypertension Prospective Cohort Study Across the Adult Age Span",

abstract = "Midlife hypertension is a risk factor for dementia, but little is known about the cognitive trajectories of individuals with incident hypertension. This study follows the cognitive functioning in prevalent and incident hypertension for 12 years and in relation to age and treatment status. Cognitively intact adults aged 25 to 84 years (n=1805) were serially assessed at baseline, 6 years, and 12 years. Hypertension was defined by sphygmomanometry or antihypertensive medication use, and its association with cognitive decline was tested in random-effects models. At baseline, 638 (35.3%) participants had hypertension. They showed faster decline in memory (chi(2) test for homogeneity=35.75; df=2; P",

keywords = "cognition, cohort studies, dementia, epidemiology, neuropsychology",

author = "Sebastian Kohler and Baars, {Maria A. E.} and Peggy Spauwen and Syenna Schievink and Verhey, {Frans R. J.} and {van Boxtel}, {Martin J. P.}",

year = "2014",

month = feb,

doi = "10.1161/HYPERTENSIONAHA.113.02096",

language = "English",

volume = "63",

pages = "245–251",

journal = "Hypertension",

issn = "0194-911X",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "2",

}

TY - JOUR

T1 - Temporal Evolution of Cognitive Changes in Incident Hypertension Prospective Cohort Study Across the Adult Age Span

AU - Kohler, Sebastian

AU - Baars, Maria A. E.

AU - Spauwen, Peggy

AU - Schievink, Syenna

AU - Verhey, Frans R. J.

AU - van Boxtel, Martin J. P.

PY - 2014/2

Y1 - 2014/2

N2 - Midlife hypertension is a risk factor for dementia, but little is known about the cognitive trajectories of individuals with incident hypertension. This study follows the cognitive functioning in prevalent and incident hypertension for 12 years and in relation to age and treatment status. Cognitively intact adults aged 25 to 84 years (n=1805) were serially assessed at baseline, 6 years, and 12 years. Hypertension was defined by sphygmomanometry or antihypertensive medication use, and its association with cognitive decline was tested in random-effects models. At baseline, 638 (35.3%) participants had hypertension. They showed faster decline in memory (chi(2) test for homogeneity=35.75; df=2; P

AB - Midlife hypertension is a risk factor for dementia, but little is known about the cognitive trajectories of individuals with incident hypertension. This study follows the cognitive functioning in prevalent and incident hypertension for 12 years and in relation to age and treatment status. Cognitively intact adults aged 25 to 84 years (n=1805) were serially assessed at baseline, 6 years, and 12 years. Hypertension was defined by sphygmomanometry or antihypertensive medication use, and its association with cognitive decline was tested in random-effects models. At baseline, 638 (35.3%) participants had hypertension. They showed faster decline in memory (chi(2) test for homogeneity=35.75; df=2; P

KW - cognition

KW - cohort studies

KW - dementia

KW - epidemiology

KW - neuropsychology

U2 - 10.1161/HYPERTENSIONAHA.113.02096

DO - 10.1161/HYPERTENSIONAHA.113.02096

M3 - Article

C2 - 24296281

SN - 0194-911X

VL - 63

SP - 245

EP - 251

JO - Hypertension

JF - Hypertension

IS - 2

ER -