Temporal Evolution of Cognitive Changes in Incident Hypertension Prospective Cohort Study Across the Adult Age Span

Sebastian Kohler*, Maria A. E. Baars, Peggy Spauwen, Syenna Schievink, Frans R. J. Verhey, Martin J. P. van Boxtel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Midlife hypertension is a risk factor for dementia, but little is known about the cognitive trajectories of individuals with incident hypertension. This study follows the cognitive functioning in prevalent and incident hypertension for 12 years and in relation to age and treatment status. Cognitively intact adults aged 25 to 84 years (n=1805) were serially assessed at baseline, 6 years, and 12 years. Hypertension was defined by sphygmomanometry or antihypertensive medication use, and its association with cognitive decline was tested in random-effects models. At baseline, 638 (35.3%) participants had hypertension. They showed faster decline in memory (chi(2) test for homogeneity=35.75; df=2; P
Original languageEnglish
Pages (from-to)245–251
Issue number2
Publication statusPublished - Feb 2014


  • cognition
  • cohort studies
  • dementia
  • epidemiology
  • neuropsychology

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