Temporal Evolution of Cognitive Changes in Incident Hypertension Prospective Cohort Study Across the Adult Age Span

Sebastian Kohler; Maria A. E. Baars; Peggy Spauwen; Syenna Schievink; Frans R. J. Verhey; Martin J. P. van Boxtel

doi:10.1161/HYPERTENSIONAHA.113.02096

Temporal Evolution of Cognitive Changes in Incident Hypertension Prospective Cohort Study Across the Adult Age Span

Sebastian Kohler^*, Maria A. E. Baars, Peggy Spauwen, Syenna Schievink, Frans R. J. Verhey, Martin J. P. van Boxtel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

63 Citations (Web of Science)

Abstract

Midlife hypertension is a risk factor for dementia, but little is known about the cognitive trajectories of individuals with incident hypertension. This study follows the cognitive functioning in prevalent and incident hypertension for 12 years and in relation to age and treatment status. Cognitively intact adults aged 25 to 84 years (n=1805) were serially assessed at baseline, 6 years, and 12 years. Hypertension was defined by sphygmomanometry or antihypertensive medication use, and its association with cognitive decline was tested in random-effects models. At baseline, 638 (35.3%) participants had hypertension. They showed faster decline in memory (chi(2) test for homogeneity=35.75; df=2; P

Original language	English
Pages (from-to)	245-+
Journal	Hypertension
Volume	63
Issue number	2
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.113.02096
Publication status	Published - Feb 2014

Keywords

cognition
cohort studies
dementia
epidemiology
neuropsychology

Access to Document

10.1161/HYPERTENSIONAHA.113.02096

Cite this

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abstract = "Midlife hypertension is a risk factor for dementia, but little is known about the cognitive trajectories of individuals with incident hypertension. This study follows the cognitive functioning in prevalent and incident hypertension for 12 years and in relation to age and treatment status. Cognitively intact adults aged 25 to 84 years (n=1805) were serially assessed at baseline, 6 years, and 12 years. Hypertension was defined by sphygmomanometry or antihypertensive medication use, and its association with cognitive decline was tested in random-effects models. At baseline, 638 (35.3%) participants had hypertension. They showed faster decline in memory (chi(2) test for homogeneity=35.75; df=2; P",

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