Temperature threshold testing: a systematic review

Mayienne Bakkers; Karin Faber; Martine J. H. Peters; Jos P. H. Reulen; Hessel Franssen; Tanya Z. Fischer; Ingemar S. J. Merkies

doi:10.1111/jns5.12001

Temperature threshold testing: a systematic review

Mayienne Bakkers, Karin Faber, Martine J. H. Peters, Jos P. H. Reulen, Hessel Franssen, Tanya Z. Fischer, Ingemar S. J. Merkies^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The diagnosis of small fiber neuropathy (SFN) has been recently defined as typical symptoms due to small nerve fiber dysfunction accompanied by reduced intra-epidermal nerve fiber density (IENFD) or abnormal temperature threshold testing (TTT). Guidelines have been published for the assessment of IENFD. However, international guidelines for TTT are lacking. This paper presents a systematic literature review on reported TTT methods and provides recommendations for its future use in studies evaluating patients. A total of 164 papers fulfilled pre-defined requirements and were selected for review. Over 15 types of instruments are currently being used with a variety of methodological approaches for location, stimulus application, and sensation qualities examined. Consensus is needed to standardize the use of TTT as a diagnostic and follow-up tool in patients.

Original language	English
Pages (from-to)	7-18
Journal	Journal of the Peripheral Nervous System
Volume	18
Issue number	1
DOIs	https://doi.org/10.1111/jns5.12001
Publication status	Published - Mar 2013

Keywords

quantitative sensory testing
small fiber neuropathy
temperature threshold testing

Access to Document

10.1111/jns5.12001

Cite this

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title = "Temperature threshold testing: a systematic review",

abstract = "The diagnosis of small fiber neuropathy (SFN) has been recently defined as typical symptoms due to small nerve fiber dysfunction accompanied by reduced intra-epidermal nerve fiber density (IENFD) or abnormal temperature threshold testing (TTT). Guidelines have been published for the assessment of IENFD. However, international guidelines for TTT are lacking. This paper presents a systematic literature review on reported TTT methods and provides recommendations for its future use in studies evaluating patients. A total of 164 papers fulfilled pre-defined requirements and were selected for review. Over 15 types of instruments are currently being used with a variety of methodological approaches for location, stimulus application, and sensation qualities examined. Consensus is needed to standardize the use of TTT as a diagnostic and follow-up tool in patients.",

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AU - Fischer, Tanya Z.

AU - Merkies, Ingemar S. J.

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