Temperature threshold testing: a systematic review

Mayienne Bakkers; Karin Faber; Martine J. H. Peters; Jos P. H. Reulen; Hessel Franssen; Tanya Z. Fischer; Ingemar S. J. Merkies

doi:10.1111/jns5.12001

Temperature threshold testing: a systematic review

Mayienne Bakkers, Karin Faber, Martine J. H. Peters, Jos P. H. Reulen, Hessel Franssen, Tanya Z. Fischer, Ingemar S. J. Merkies^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Web of Science)

Abstract

The diagnosis of small fiber neuropathy (SFN) has been recently defined as typical symptoms due to small nerve fiber dysfunction accompanied by reduced intra-epidermal nerve fiber density (IENFD) or abnormal temperature threshold testing (TTT). Guidelines have been published for the assessment of IENFD. However, international guidelines for TTT are lacking. This paper presents a systematic literature review on reported TTT methods and provides recommendations for its future use in studies evaluating patients. A total of 164 papers fulfilled pre-defined requirements and were selected for review. Over 15 types of instruments are currently being used with a variety of methodological approaches for location, stimulus application, and sensation qualities examined. Consensus is needed to standardize the use of TTT as a diagnostic and follow-up tool in patients.

Original language	English
Pages (from-to)	7-18
Journal	Journal of the Peripheral Nervous System
Volume	18
Issue number	1
DOIs	https://doi.org/10.1111/jns5.12001
Publication status	Published - Mar 2013

Keywords

quantitative sensory testing
small fiber neuropathy
temperature threshold testing

Access to Document

10.1111/jns5.12001

Cite this

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title = "Temperature threshold testing: a systematic review",

abstract = "The diagnosis of small fiber neuropathy (SFN) has been recently defined as typical symptoms due to small nerve fiber dysfunction accompanied by reduced intra-epidermal nerve fiber density (IENFD) or abnormal temperature threshold testing (TTT). Guidelines have been published for the assessment of IENFD. However, international guidelines for TTT are lacking. This paper presents a systematic literature review on reported TTT methods and provides recommendations for its future use in studies evaluating patients. A total of 164 papers fulfilled pre-defined requirements and were selected for review. Over 15 types of instruments are currently being used with a variety of methodological approaches for location, stimulus application, and sensation qualities examined. Consensus is needed to standardize the use of TTT as a diagnostic and follow-up tool in patients.",

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AU - Fischer, Tanya Z.

AU - Merkies, Ingemar S. J.

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