Technical advances in magnetic resonance spectroscopy in metabolic research

Lucas Lindeboom

Research output: ThesisDoctoral ThesisInternal

Abstract

MRI scanners are frequently used to study human metabolic processes. This dissertation introduces advanced MR techniques to study type 2 diabetes. The developed techniques enable us to measure acetyl-carnitine, a substance that seems important to the regulation of the glucose and lipid metabolism. Direct application showed that patients with type 2 diabetes produce a less amount of this substance. Furthermore, the storage of fat from meals can now be directly monitored by a newly developed MR technique, allowing us to gain insight into the factors contributing to hepatic steatosis.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Schrauwen, Patrick, Supervisor
  • Wildberger, Joachim, Supervisor
  • Schrauwen - Hinderling, Vera, Co-Supervisor
Award date20 May 2016
Publication statusPublished - 2016

Keywords

  • MRI
  • type 2 diabetes
  • acetyl-carnitine

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