Abstract
MRI scanners are frequently used to study human metabolic processes. This dissertation introduces advanced MR techniques to study type 2 diabetes. The developed techniques enable us to measure acetyl-carnitine, a substance that seems important to the regulation of the glucose and lipid metabolism. Direct application showed that patients with type 2 diabetes produce a less amount of this substance. Furthermore, the storage of fat from meals can now be directly monitored by a newly developed MR technique, allowing us to gain insight into the factors contributing to hepatic steatosis.
Original language | English |
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Awarding Institution |
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Award date | 20 May 2016 |
DOIs | |
Publication status | Published - 2016 |
Keywords
- MRI
- type 2 diabetes
- acetyl-carnitine