Targeting the Wnt/frizzled signaling pathway after myocardial infarction: A new tool in the therapeutic toolbox?

Evangelos P. Daskalopoulos, Kevin C. M. Hermans, Ben J. A. Janssen, W. Matthijs Blankesteijn*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Wnt/frizzled signaling in the adult heart is quiescent under normal conditions; however it is reactivated after myocardial infarction (MI). Any intervention at the various levels of this pathway can modulate its signaling. Several studies have targeted Wnt/frizzled signaling after MI with the majority of them indicating that the inhibition of the pathway is beneficial since it improves infarct healing and prevents heart failure. This suggests that blocking the Wnt/frizzled signaling pathway could be a potential novel therapeutic target to prevent the adverse cardiac remodeling after MI.
Original languageEnglish
Pages (from-to)121-127
JournalTrends in Cardiovascular Medicine
Volume23
Issue number4
DOIs
Publication statusPublished - May 2013

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