Targeting the chemokine network in atherosclerosis

Yi Yan, Manovriti Thakur, Emiel P. C. van der Vorst, Christian Weber, Yvonne Doering*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Web of Science)

Abstract

Chemokines and their receptors represent a potential target for immunotherapy in chronic inflammation. They comprise a large family of cytokines with chemotactic activity, and their cognate receptors are expressed on all cells of the body. This network dictates leukocyte recruitment and activation, angiogenesis, cell proliferation and maturation. Dysregulation of chemokine and chemokine receptor expression as well as function participates in many pathologies including cancer, autoimmune diseases and chronic inflammation. In atherosclerosis, a lipiddriven chronic inflammation of middle-sized and large arteries, chemokines and their receptors participates in almost all stages of the disease from initiation of fatty streaks to mature atherosclerotic plaque formation. Atherosclerosis and its complications are the main driver of mortality and morbidity in cardiovascular diseases (CVD). Hence, exploring new fields of therapeutic targeting of atherosclerosis is of key importance. This review gives an overview of the recent advances on the role of key chemokines and chemokine receptors in atherosclerosis, addresses chemokine-based biomarkers at biochemical, imaging and genetic level in human studies, and highlights the clinial trials targeting atherosclerosis.

Original languageEnglish
Pages (from-to)95-106
Number of pages12
JournalAtherosclerosis
Volume330
DOIs
Publication statusPublished - Aug 2021

Keywords

  • Chemokines
  • Chemokine receptors
  • Cardiovascular disease
  • Atherosclerosis
  • Biomarkers
  • Gene analysis
  • Mouse models
  • MONOCYTE CHEMOATTRACTANT PROTEIN-1
  • CORONARY-ARTERY-DISEASE
  • PROMOTES ATHEROSCLEROSIS
  • REDUCES ATHEROSCLEROSIS
  • CARDIOVASCULAR-DISEASE
  • LIMITS ATHEROSCLEROSIS
  • PLATELET ACTIVATION
  • CIRCULATING LEVELS
  • LESION DEVELOPMENT
  • PROGENITOR CELLS

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