Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors

R. Keshet, J.S. Lee, L. Adler, M. Iraqi, Y. Ariav, L.Q.J. Lim, S. Lerner, S. Rabinovich, R. Oren, R. Katzir, H.W. Tishler, N. Stettner, O. Goldman, H. Landesman, S. Galai, Y. Kuperman, Y. Kuznetsov, A. Brandis, T. Mehlman, S. MalitskyM. Itkin, S.E. Koehler, Y.M. Zhao, K. Talsania, T.W. Shen, N. Peled, I. Ulitsky, A. Porgador, E. Ruppin, A. Erez

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Web of Science)
Original languageEnglish
Pages (from-to)894-908
Number of pages30
JournalNature Cancer
Volume1
Issue number9
DOIs
Publication statusPublished - 1 Sep 2020

Keywords

  • activation
  • argininosuccinate synthetase
  • deprivation
  • encyclopedia
  • expression
  • gluconeogenesis
  • liver
  • metabolism
  • s-nitrosylation
  • urea cycle
  • ACTIVATION
  • ARGININOSUCCINATE SYNTHETASE
  • S-NITROSYLATION
  • ENCYCLOPEDIA
  • METABOLISM
  • GLUCONEOGENESIS
  • DEPRIVATION
  • UREA CYCLE
  • LIVER
  • EXPRESSION

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