Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia

Alicia D'Souza, Charles M. Pearman, Yanwen Wang, Shu Nakao, Sunil Jit R. J. Logantha, Charlotte Cox, Hayley Bennett, Yu Zhang, Anne Berit Johnsen, Nora Linscheid, Pi Camilla Poulsen, Jonathan Elliott, Jessica Coulson, Jamie McPhee, Abigail Robertson, Paula A. da Costa Martins, Ashraf Kitmitto, Ulrik Wisloff, Elizabeth J. Cartwright, Oliver MonfrediAlicia Lundby, Halina Dobrzynski, Delvac Oceandy, Gwilym M. Morris, Mark R. Boyett*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1058-1068
Number of pages32
JournalCirculation Research
Volume121
Issue number9
DOIs
Publication statusPublished - 13 Oct 2017

Keywords

  • athletes
  • exercise training
  • ion channel remodeling
  • micro-RNAs
  • sinoatrial node
  • sinus bradycardia
  • O-GLCNAC TRANSFERASE
  • HIGH VAGAL TONE
  • SINOATRIAL NODE
  • HEART-FAILURE
  • CARDIOMYOCYTE DIFFERENTIATION
  • ATRIAL-FIBRILLATION
  • ENDURANCE EXERCISE
  • INTRONIC MICRORNAS
  • DOWN-REGULATION
  • HOST GENES

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