Targeting citrullination in autoimmunity: insights learned from preclinical mouse models

Ylke Bruggeman, Fernanda M. C. Sodre, Mijke Buitinga, Chantal Mathieu, Lut Overbergh*, Maria J. L. Kracht

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Original languageEnglish
Pages (from-to)269-281
Number of pages13
JournalExpert Opinion on Therapeutic Targets
Volume25
Issue number4
DOIs
Publication statusPublished - 3 Apr 2021

Keywords

  • Autoimmune disease
  • citrullination
  • immunomodulation
  • PAD isozyme-specific inhibitors
  • pan-PAD inhibitors
  • peptidylarginine deiminases
  • preclinical mouse models
  • therapeutic targets
  • drug targets
  • PROTEIN ARGININE DEIMINASE
  • RAY CRYSTALLOGRAPHIC ANALYSIS
  • PEPTIDYLARGININE-DEIMINASE
  • RHEUMATOID-ARTHRITIS
  • EXTRACELLULAR TRAPS
  • MULTIPLE-SCLEROSIS
  • CL-AMIDINE
  • HISTONE CITRULLINATION
  • BIOLOGICAL EVALUATION
  • IMMUNE-RESPONSES

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