Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity

Madelon Q. Wentink; Tilman M. Hackeng; Sebastien P. Tabruyn; Wouter C. Puijk; Klaus Schwamborn; Daniele Altschuh; Rob H. Meloen; Teun Schuurman; Arjan W. Griffioen; Peter Timmerman

doi:10.1073/pnas.1610258113

Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity

Madelon Q. Wentink, Tilman M. Hackeng, Sebastien P. Tabruyn, Wouter C. Puijk, Klaus Schwamborn, Daniele Altschuh, Rob H. Meloen, Teun Schuurman, Arjan W. Griffioen^*, Peter Timmerman^*

^*Corresponding author for this work

Biochemie

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Web of Science)

Original language	English
Pages (from-to)	12532-12537
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	113
Issue number	44
DOIs	https://doi.org/10.1073/pnas.1610258113
Publication status	Published - 1 Nov 2016

Keywords

VEGF
angiogenesis
immunization
protein mimicry
peptide vaccines

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10.1073/pnas.1610258113

Cite this

Wentink, M. Q., Hackeng, T. M., Tabruyn, S. P., Puijk, W. C., Schwamborn, K., Altschuh, D., Meloen, R. H., Schuurman, T., Griffioen, A. W., & Timmerman, P. (2016). Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity. Proceedings of the National Academy of Sciences of the United States of America, 113(44), 12532-12537. https://doi.org/10.1073/pnas.1610258113

Wentink, Madelon Q. ; Hackeng, Tilman M. ; Tabruyn, Sebastien P. ; Puijk, Wouter C. ; Schwamborn, Klaus ; Altschuh, Daniele ; Meloen, Rob H. ; Schuurman, Teun ; Griffioen, Arjan W. ; Timmerman, Peter. / Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity. In: Proceedings of the National Academy of Sciences of the United States of America. 2016 ; Vol. 113, No. 44. pp. 12532-12537.

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keywords = "VEGF, angiogenesis, immunization, protein mimicry, peptide vaccines",

author = "Wentink, {Madelon Q.} and Hackeng, {Tilman M.} and Tabruyn, {Sebastien P.} and Puijk, {Wouter C.} and Klaus Schwamborn and Daniele Altschuh and Meloen, {Rob H.} and Teun Schuurman and Griffioen, {Arjan W.} and Peter Timmerman",

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Wentink, MQ, Hackeng, TM, Tabruyn, SP, Puijk, WC, Schwamborn, K, Altschuh, D, Meloen, RH, Schuurman, T, Griffioen, AW & Timmerman, P 2016, 'Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 44, pp. 12532-12537. https://doi.org/10.1073/pnas.1610258113

Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity. / Wentink, Madelon Q.; Hackeng, Tilman M.; Tabruyn, Sebastien P.; Puijk, Wouter C.; Schwamborn, Klaus; Altschuh, Daniele; Meloen, Rob H.; Schuurman, Teun; Griffioen, Arjan W.; Timmerman, Peter.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 44, 01.11.2016, p. 12532-12537.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Wentink, Madelon Q.

AU - Hackeng, Tilman M.

AU - Tabruyn, Sebastien P.

AU - Puijk, Wouter C.

AU - Schwamborn, Klaus

AU - Altschuh, Daniele

AU - Meloen, Rob H.

AU - Schuurman, Teun

AU - Griffioen, Arjan W.

AU - Timmerman, Peter

PY - 2016/11/1

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KW - VEGF

KW - angiogenesis

KW - immunization

KW - protein mimicry

KW - peptide vaccines

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DO - 10.1073/pnas.1610258113

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VL - 113

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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