Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity

Madelon Q. Wentink; Tilman M. Hackeng; Sebastien P. Tabruyn; Wouter C. Puijk; Klaus Schwamborn; Daniele Altschuh; Rob H. Meloen; Teun Schuurman; Arjan W. Griffioen; Peter Timmerman

doi:10.1073/pnas.1610258113

Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity

Madelon Q. Wentink, Tilman M. Hackeng, Sebastien P. Tabruyn, Wouter C. Puijk, Klaus Schwamborn, Daniele Altschuh, Rob H. Meloen, Teun Schuurman, Arjan W. Griffioen, Peter Timmerman

Biochemie

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	12532-12537
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	113
Issue number	44
DOIs	https://doi.org/10.1073/pnas.1610258113
Publication status	Published - 1 Nov 2016

Keywords

VEGF
angiogenesis
immunization
protein mimicry
peptide vaccines

Access to Document

10.1073/pnas.1610258113

Cite this

Wentink, M. Q., Hackeng, T. M., Tabruyn, S. P., Puijk, W. C., Schwamborn, K., Altschuh, D., Meloen, R. H., Schuurman, T., Griffioen, A. W., & Timmerman, P. (2016). Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity. Proceedings of the National Academy of Sciences of the United States of America, 113(44), 12532-12537. https://doi.org/10.1073/pnas.1610258113

Wentink, Madelon Q. ; Hackeng, Tilman M. ; Tabruyn, Sebastien P. ; Puijk, Wouter C. ; Schwamborn, Klaus ; Altschuh, Daniele ; Meloen, Rob H. ; Schuurman, Teun ; Griffioen, Arjan W. ; Timmerman, Peter. / Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity. In: Proceedings of the National Academy of Sciences of the United States of America. 2016 ; Vol. 113, No. 44. pp. 12532-12537.

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title = "Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity",

keywords = "VEGF, angiogenesis, immunization, protein mimicry, peptide vaccines",

author = "Wentink, {Madelon Q.} and Hackeng, {Tilman M.} and Tabruyn, {Sebastien P.} and Puijk, {Wouter C.} and Klaus Schwamborn and Daniele Altschuh and Meloen, {Rob H.} and Teun Schuurman and Griffioen, {Arjan W.} and Peter Timmerman",

year = "2016",

month = nov,

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doi = "10.1073/pnas.1610258113",

language = "English",

volume = "113",

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journal = "Proceedings of the National Academy of Sciences of the United States of America",

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Wentink, MQ, Hackeng, TM, Tabruyn, SP, Puijk, WC, Schwamborn, K, Altschuh, D, Meloen, RH, Schuurman, T, Griffioen, AW & Timmerman, P 2016, 'Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 44, pp. 12532-12537. https://doi.org/10.1073/pnas.1610258113

Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity. / Wentink, Madelon Q.; Hackeng, Tilman M.; Tabruyn, Sebastien P.; Puijk, Wouter C.; Schwamborn, Klaus; Altschuh, Daniele; Meloen, Rob H.; Schuurman, Teun; Griffioen, Arjan W.; Timmerman, Peter.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 44, 01.11.2016, p. 12532-12537.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity

AU - Wentink, Madelon Q.

AU - Hackeng, Tilman M.

AU - Tabruyn, Sebastien P.

AU - Puijk, Wouter C.

AU - Schwamborn, Klaus

AU - Altschuh, Daniele

AU - Meloen, Rob H.

AU - Schuurman, Teun

AU - Griffioen, Arjan W.

AU - Timmerman, Peter

PY - 2016/11/1

Y1 - 2016/11/1

KW - VEGF

KW - angiogenesis

KW - immunization

KW - protein mimicry

KW - peptide vaccines

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DO - 10.1073/pnas.1610258113

M3 - Article

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SP - 12532

EP - 12537

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 44

ER -