Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis

Elliott Rees, Noa Carrera, Joanne Morgan, Kirsty Hambridge, Valentina Escott-Price, Andrew J. Pocklington, Alexander L. Richards, Antonio F. Pardinas, Colm McDonald, Gary Donohoe, Derek W. Morris, Elaine Kenny, Eric Kelleher, Michael Gill, Aiden Corvin, George Kirov, James T. R. Walters, Peter Holmans, Michael J. Owen, Michael C. O'DonovanBehrooz Z. Alizadeh, Therese van Amelsvoort, Agna A. Bartels-Velthuis, Nico J. van Beveren, Richard Bruggeman, Wiepke Cahn, Lieuwe de Haan, Philippe Delespaul, Carin J. Meijer, Inez Myin-Germeys, Rene S. Kahn, Frederike Schirmbeck, Claudia J. P. Simons, Neeltje E. van Haren, Jim van Os, Ruud van Winkel, Jurjen J. Luykx, GRP Investigators

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)554-562
Number of pages9
JournalBiological Psychiatry
Volume85
Issue number7
DOIs
Publication statusPublished - 1 Apr 2019

Keywords

  • ARC
  • Genetics
  • NMDAR
  • Schizophrenia
  • Sequencing
  • Voltage-gated sodium channels
  • DE-NOVO MUTATIONS
  • GENOME-WIDE ASSOCIATION
  • OF-FUNCTION VARIANTS
  • RISK
  • INDIVIDUALS
  • FRAMEWORK
  • SUSCEPTIBILITY
  • DISORDERS
  • SETD1A
  • BURDEN

Cite this

Rees, E., Carrera, N., Morgan, J., Hambridge, K., Escott-Price, V., Pocklington, A. J., Richards, A. L., Pardinas, A. F., McDonald, C., Donohoe, G., Morris, D. W., Kenny, E., Kelleher, E., Gill, M., Corvin, A., Kirov, G., Walters, J. T. R., Holmans, P., Owen, M. J., ... GRP Investigators (2019). Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis. Biological Psychiatry, 85(7), 554-562. https://doi.org/10.1016/j.biopsych.2018.08.022