Targeted Imaging for Cell Death in Cardiovascular Disorders

Aditya Shekhar, Peter Heeger, Chris Reutelingsperger, Eloisa Arbustini, Navneet Narula, Leonard Hofstra, Jeroen J. Bax, Jagat Narula*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

21 Citations (Web of Science)

Abstract

Cell death is desirable in cancer cells and undesirable in organs with limited regenerative potential, like the heart. Cell death comes inmany forms, but only apoptosis and to a lesser degree necrosis is currently relevant to the clinical imager. Noninvasive imaging of cell death is an attractive option to understand pathophysiology, track disease activity, and evaluate response to intervention. Apoptosis seems to be the most promising target for imaging cell death, because it could be reversible and might be modulated with interventions. Molecular, nuclear, optical, or magnetic resonance imaging-based methods have been developed to identify intermediate steps in the apoptosis cascade. Animal studies show promising results for noninvasive imaging in various cardiovascular diseases. Human studies have shown feasibility, but clinical use is yet inconclusive. Newer technologies offer promise, especially for tracking apoptosis in evaluation of novel therapeutic interventions. (C) 2018 Published by Elsevier on behalf of the American College of Cardiology Foundation.
Original languageEnglish
Pages (from-to)476-493
Number of pages18
JournalJACC-Cardiovascular Imaging
Volume11
Issue number3
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • coronary artery stenosis
  • myocardial ischemia
  • revascularization
  • stable ischemic heart disease
  • vulnerable plaque
  • ACUTE MYOCARDIAL-INFARCTION
  • IN-VIVO DETECTION
  • F-18-FLUOROBENZYL TRIPHENYL PHOSPHONIUM
  • MULTISPECTRAL OPTOACOUSTIC TOMOGRAPHY
  • ISCHEMIA-REPERFUSION INJURY
  • CARDIAC MYOCYTE APOPTOSIS
  • ANNEXIN-V
  • NONINVASIVE DETECTION
  • HEART-FAILURE
  • ATHEROSCLEROTIC LESIONS

Cite this