Targeted endoradiotherapy using nucleotides

A. Morgenroth; A.T. Vogg; F.M. Mottaghy; J. Schmaljohann

doi:10.1016/j.ymeth.2011.06.009

Targeted endoradiotherapy using nucleotides

A. Morgenroth^*, A.T. Vogg, F.M. Mottaghy, J. Schmaljohann

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Increased cellular proliferation is an integral part of the cancer phenotype. Hence, the sustained and continued demand on supply of DNA building blocks during the DNA replication presents a potential target for therapeutic intervention. For this propose, the alpha and Auger electron emitting nucleotides analogs are attractive for targeted endoradiotherapy, given that DNA of malignant cells is selectively addressed. This review summarizes development and preclinical and clinical studies of endoradiotherapeutic acting nucleoside analogs with a special focus on thymidine analogs.

Original language	English
Pages (from-to)	203-214
Number of pages	12
Journal	Methods
Volume	55
Issue number	3
DOIs	https://doi.org/10.1016/j.ymeth.2011.06.009
Publication status	Published - Nov 2011

Keywords

Endoradiotherapy
alpha Emitter
Auger emitter
Nucleoside analogs
ELECTRON-EMITTING RADIONUCLIDES
HUMAN GLIOBLASTOMA XENOGRAFTS
DEOXYGUANOSINE KINASE CDNA
HUMAN DEOXYCYTIDINE KINASE
HUMAN THYMIDINE KINASE
DOUBLE-STRAND BREAK
GROUP NO 6
MAMMALIAN-CELLS
IN-VIVO
GENE-EXPRESSION

Access to Document

10.1016/j.ymeth.2011.06.009

Cite this

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title = "Targeted endoradiotherapy using nucleotides",

abstract = "Increased cellular proliferation is an integral part of the cancer phenotype. Hence, the sustained and continued demand on supply of DNA building blocks during the DNA replication presents a potential target for therapeutic intervention. For this propose, the alpha and Auger electron emitting nucleotides analogs are attractive for targeted endoradiotherapy, given that DNA of malignant cells is selectively addressed. This review summarizes development and preclinical and clinical studies of endoradiotherapeutic acting nucleoside analogs with a special focus on thymidine analogs.",

keywords = "Endoradiotherapy, alpha Emitter, Auger emitter, Nucleoside analogs, ELECTRON-EMITTING RADIONUCLIDES, HUMAN GLIOBLASTOMA XENOGRAFTS, DEOXYGUANOSINE KINASE CDNA, HUMAN DEOXYCYTIDINE KINASE, HUMAN THYMIDINE KINASE, DOUBLE-STRAND BREAK, GROUP NO 6, MAMMALIAN-CELLS, IN-VIVO, GENE-EXPRESSION",

author = "A. Morgenroth and A.T. Vogg and F.M. Mottaghy and J. Schmaljohann",

year = "2011",

month = nov,

doi = "10.1016/j.ymeth.2011.06.009",

language = "English",

volume = "55",

pages = "203--214",

journal = "Methods",

issn = "1046-2023",

publisher = "Elsevier Science",

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TY - JOUR

T1 - Targeted endoradiotherapy using nucleotides

AU - Morgenroth, A.

AU - Vogg, A.T.

AU - Mottaghy, F.M.

AU - Schmaljohann, J.

PY - 2011/11

Y1 - 2011/11

N2 - Increased cellular proliferation is an integral part of the cancer phenotype. Hence, the sustained and continued demand on supply of DNA building blocks during the DNA replication presents a potential target for therapeutic intervention. For this propose, the alpha and Auger electron emitting nucleotides analogs are attractive for targeted endoradiotherapy, given that DNA of malignant cells is selectively addressed. This review summarizes development and preclinical and clinical studies of endoradiotherapeutic acting nucleoside analogs with a special focus on thymidine analogs.

AB - Increased cellular proliferation is an integral part of the cancer phenotype. Hence, the sustained and continued demand on supply of DNA building blocks during the DNA replication presents a potential target for therapeutic intervention. For this propose, the alpha and Auger electron emitting nucleotides analogs are attractive for targeted endoradiotherapy, given that DNA of malignant cells is selectively addressed. This review summarizes development and preclinical and clinical studies of endoradiotherapeutic acting nucleoside analogs with a special focus on thymidine analogs.

KW - Endoradiotherapy

KW - alpha Emitter

KW - Auger emitter

KW - Nucleoside analogs

KW - ELECTRON-EMITTING RADIONUCLIDES

KW - HUMAN GLIOBLASTOMA XENOGRAFTS

KW - DEOXYGUANOSINE KINASE CDNA

KW - HUMAN DEOXYCYTIDINE KINASE

KW - HUMAN THYMIDINE KINASE

KW - DOUBLE-STRAND BREAK

KW - GROUP NO 6

KW - MAMMALIAN-CELLS

KW - IN-VIVO

KW - GENE-EXPRESSION

U2 - 10.1016/j.ymeth.2011.06.009

DO - 10.1016/j.ymeth.2011.06.009

M3 - Article

C2 - 21782950

SN - 1046-2023

VL - 55

SP - 203

EP - 214

JO - Methods

JF - Methods

IS - 3

ER -