Targeted endoradiotherapy using nucleotides

A. Morgenroth, A.T. Vogg, F.M. Mottaghy, J. Schmaljohann

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Increased cellular proliferation is an integral part of the cancer phenotype. Hence, the sustained and continued demand on supply of DNA building blocks during the DNA replication presents a potential target for therapeutic intervention. For this propose, the alpha and Auger electron emitting nucleotides analogs are attractive for targeted endoradiotherapy, given that DNA of malignant cells is selectively addressed. This review summarizes development and preclinical and clinical studies of endoradiotherapeutic acting nucleoside analogs with a special focus on thymidine analogs.
Original languageEnglish
Pages (from-to)203-214
Number of pages12
JournalMethods
Volume55
Issue number3
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Endoradiotherapy
  • alpha Emitter
  • Auger emitter
  • Nucleoside analogs
  • ELECTRON-EMITTING RADIONUCLIDES
  • HUMAN GLIOBLASTOMA XENOGRAFTS
  • DEOXYGUANOSINE KINASE CDNA
  • HUMAN DEOXYCYTIDINE KINASE
  • HUMAN THYMIDINE KINASE
  • DOUBLE-STRAND BREAK
  • GROUP NO 6
  • MAMMALIAN-CELLS
  • IN-VIVO
  • GENE-EXPRESSION

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