TY - JOUR
T1 - Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies
AU - Deckers, Kay
AU - van Boxtel, Martin P. J.
AU - Schiepers, Olga J. G.
AU - de Vugt, Marjolein
AU - Munoz Sanchez, Juan Luis
AU - Anstey, Kaarin J.
AU - Brayne, Carol
AU - Dartigues, Jean-Francois
AU - Engedal, Knut
AU - Kivipelto, Miia
AU - Ritchie, Karen
AU - Starr, John M.
AU - Yaffe, Kristine
AU - Irving, Kate
AU - Verhey, Frans R. J.
AU - Kohler, Sebastian
PY - 2015/3
Y1 - 2015/3
N2 - ObjectiveDementia has a multifactorial etiology, but the importance of individual health and lifestyle related risk factors is often uncertain or based on few studies. The goal of this paper is to identify the major modifiable risk factors for dementia as a first step in developing an effective preventive strategy and promoting healthy late life cognitive functioning. MethodsA mixed-method approach combined findings from a systematic literature review and a Delphi consensus study. The literature search was conducted in PubMed and updated an earlier review by the United States National Institutes of Health from 2010. We reviewed the available evidence from observational epidemiological studies. The online Delphi study asked eight international experts to rank and weigh each risk factor for its importance for dementia prevention. ResultsOut of 3127 abstracts, 291 were included in the review. There was good agreement between modifiable risk factors identified in the literature review and risk factors named spontaneously by experts. After triangulation of both methods and re-weighting by experts, strongest support was found for depression, (midlife) hypertension, physical inactivity, diabetes, (midlife) obesity, hyperlipidemia, and smoking, while more research is needed for coronary heart disease, renal dysfunction, diet, and cognitive activity. ConclusionsFindings provide good support for several somatic and lifestyle factors and will be used to inform the design of a new multicenter trial into dementia prevention.
AB - ObjectiveDementia has a multifactorial etiology, but the importance of individual health and lifestyle related risk factors is often uncertain or based on few studies. The goal of this paper is to identify the major modifiable risk factors for dementia as a first step in developing an effective preventive strategy and promoting healthy late life cognitive functioning. MethodsA mixed-method approach combined findings from a systematic literature review and a Delphi consensus study. The literature search was conducted in PubMed and updated an earlier review by the United States National Institutes of Health from 2010. We reviewed the available evidence from observational epidemiological studies. The online Delphi study asked eight international experts to rank and weigh each risk factor for its importance for dementia prevention. ResultsOut of 3127 abstracts, 291 were included in the review. There was good agreement between modifiable risk factors identified in the literature review and risk factors named spontaneously by experts. After triangulation of both methods and re-weighting by experts, strongest support was found for depression, (midlife) hypertension, physical inactivity, diabetes, (midlife) obesity, hyperlipidemia, and smoking, while more research is needed for coronary heart disease, renal dysfunction, diet, and cognitive activity. ConclusionsFindings provide good support for several somatic and lifestyle factors and will be used to inform the design of a new multicenter trial into dementia prevention.
KW - epidemiology
KW - risk factors
KW - prevention
KW - dementia
KW - public health
U2 - 10.1002/gps.4245
DO - 10.1002/gps.4245
M3 - Article
C2 - 25504093
VL - 30
SP - 234
EP - 246
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
SN - 0885-6230
IS - 3
ER -