T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

Emma T M Peereboom; Benedict M Matern; Toshihide Tomosugi; Matthias Niemann; Julia Drylewicz; Irma Joosten; Wil A Allebes; Arnold van der Meer; Luuk B Hilbrands; Marije C Baas; Franka E van Reekum; Marianne C Verhaar; Elena G Kamburova; Marc A J Seelen; Jan Stephan Sanders; Bouke G Hepkema; Annechien J Lambeck; Laura B Bungener; Caroline Roozendaal; Marcel G J Tilanus; Christien E Voorter; Lotte Wieten; Elly M van Duijnhoven; Mariëlle A C J Gelens; Maarten H L Christiaans; Frans J van Ittersum; Azam Nurmohamed; Neubury M Lardy; Wendy Swelsen; Karlijn A van der Pant; Neelke C van der Weerd; Ineke J M Ten Berge; Fréderike J Bemelman; Aiko P J de Vries; Johan W de Fijter; Michiel G H Betjes; Dave L Roelen; Frans H Claas; Henny G Otten; Sebastiaan Heidt; Arjan D van Zuilen; Takaaki Kobayashi; Kirsten Geneugelijk; Eric Spierings

doi:10.3389/fimmu.2021.784040

T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

Emma T M Peereboom^*, Benedict M Matern, Toshihide Tomosugi, Matthias Niemann, Julia Drylewicz, Irma Joosten, Wil A Allebes, Arnold van der Meer, Luuk B Hilbrands, Marije C Baas, Franka E van Reekum, Marianne C Verhaar, Elena G Kamburova, Marc A J Seelen, Jan Stephan Sanders, Bouke G Hepkema, Annechien J Lambeck, Laura B Bungener, Caroline Roozendaal, Marcel G J TilanusChristien E Voorter, Lotte Wieten, Elly M van Duijnhoven, Mariëlle A C J Gelens, Maarten H L Christiaans, Frans J van Ittersum, Azam Nurmohamed, Neubury M Lardy, Wendy Swelsen, Karlijn A van der Pant, Neelke C van der Weerd, Ineke J M Ten Berge, Fréderike J Bemelman, Aiko P J de Vries, Johan W de Fijter, Michiel G H Betjes, Dave L Roelen, Frans H Claas, Henny G Otten, Sebastiaan Heidt, Arjan D van Zuilen, Takaaki Kobayashi, Kirsten Geneugelijk, Eric Spierings

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	784040
Number of pages	13
Journal	Frontiers in Immunology
Volume	12
DOIs	https://doi.org/10.3389/fimmu.2021.784040
Publication status	Published - 18 Nov 2021

Keywords

HLA antigens
PIRCHE-II
graft failure
kidney transplantation
shared T-cell epitopes
T-cell epitope
T-cell memory
ANTIBODY-MEDIATED REJECTION
INDIRECT RECOGNITION
CROSS-VALIDATION
DR PEPTIDES
ANTIGEN
LYMPHOCYTES
ALLOCATION
MEMORY
ASSAY
HELP

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10.3389/fimmu.2021.784040

Cite this

Peereboom, E. T. M., Matern, B. M., Tomosugi, T., Niemann, M., Drylewicz, J., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., van Reekum, F. E., Verhaar, M. C., Kamburova, E. G., Seelen, M. A. J., Sanders, J. S., Hepkema, B. G., Lambeck, A. J., Bungener, L. B., Roozendaal, C., ... Spierings, E. (2021). T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation. Frontiers in Immunology, 12, [784040]. https://doi.org/10.3389/fimmu.2021.784040

Peereboom, Emma T M ; Matern, Benedict M ; Tomosugi, Toshihide ; Niemann, Matthias ; Drylewicz, Julia ; Joosten, Irma ; Allebes, Wil A ; van der Meer, Arnold ; Hilbrands, Luuk B ; Baas, Marije C ; van Reekum, Franka E ; Verhaar, Marianne C ; Kamburova, Elena G ; Seelen, Marc A J ; Sanders, Jan Stephan ; Hepkema, Bouke G ; Lambeck, Annechien J ; Bungener, Laura B ; Roozendaal, Caroline ; Tilanus, Marcel G J ; Voorter, Christien E ; Wieten, Lotte ; van Duijnhoven, Elly M ; Gelens, Mariëlle A C J ; Christiaans, Maarten H L ; van Ittersum, Frans J ; Nurmohamed, Azam ; Lardy, Neubury M ; Swelsen, Wendy ; van der Pant, Karlijn A ; van der Weerd, Neelke C ; Ten Berge, Ineke J M ; Bemelman, Fréderike J ; de Vries, Aiko P J ; de Fijter, Johan W ; Betjes, Michiel G H ; Roelen, Dave L ; Claas, Frans H ; Otten, Henny G ; Heidt, Sebastiaan ; van Zuilen, Arjan D ; Kobayashi, Takaaki ; Geneugelijk, Kirsten ; Spierings, Eric. / T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation. In: Frontiers in Immunology. 2021 ; Vol. 12.

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title = "T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation",

keywords = "HLA antigens, PIRCHE-II, graft failure, kidney transplantation, shared T-cell epitopes, T-cell epitope, T-cell memory, ANTIBODY-MEDIATED REJECTION, INDIRECT RECOGNITION, CROSS-VALIDATION, DR PEPTIDES, ANTIGEN, LYMPHOCYTES, ALLOCATION, MEMORY, ASSAY, HELP",

author = "Peereboom, {Emma T M} and Matern, {Benedict M} and Toshihide Tomosugi and Matthias Niemann and Julia Drylewicz and Irma Joosten and Allebes, {Wil A} and {van der Meer}, Arnold and Hilbrands, {Luuk B} and Baas, {Marije C} and {van Reekum}, {Franka E} and Verhaar, {Marianne C} and Kamburova, {Elena G} and Seelen, {Marc A J} and Sanders, {Jan Stephan} and Hepkema, {Bouke G} and Lambeck, {Annechien J} and Bungener, {Laura B} and Caroline Roozendaal and Tilanus, {Marcel G J} and Voorter, {Christien E} and Lotte Wieten and {van Duijnhoven}, {Elly M} and Gelens, {Mari{\"e}lle A C J} and Christiaans, {Maarten H L} and {van Ittersum}, {Frans J} and Azam Nurmohamed and Lardy, {Neubury M} and Wendy Swelsen and {van der Pant}, {Karlijn A} and {van der Weerd}, {Neelke C} and {Ten Berge}, {Ineke J M} and Bemelman, {Fr{\'e}derike J} and {de Vries}, {Aiko P J} and {de Fijter}, {Johan W} and Betjes, {Michiel G H} and Roelen, {Dave L} and Claas, {Frans H} and Otten, {Henny G} and Sebastiaan Heidt and {van Zuilen}, {Arjan D} and Takaaki Kobayashi and Kirsten Geneugelijk and Eric Spierings",

note = ".",

year = "2021",

month = nov,

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doi = "10.3389/fimmu.2021.784040",

language = "English",

volume = "12",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Media S.A.",

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Peereboom, ETM, Matern, BM, Tomosugi, T, Niemann, M, Drylewicz, J, Joosten, I, Allebes, WA, van der Meer, A, Hilbrands, LB, Baas, MC, van Reekum, FE, Verhaar, MC, Kamburova, EG, Seelen, MAJ, Sanders, JS, Hepkema, BG, Lambeck, AJ, Bungener, LB, Roozendaal, C, Tilanus, MGJ, Voorter, CE , Wieten, L , van Duijnhoven, EM , Gelens, MACJ , Christiaans, MHL, van Ittersum, FJ, Nurmohamed, A, Lardy, NM, Swelsen, W, van der Pant, KA, van der Weerd, NC, Ten Berge, IJM, Bemelman, FJ, de Vries, APJ, de Fijter, JW, Betjes, MGH, Roelen, DL, Claas, FH, Otten, HG, Heidt, S, van Zuilen, AD, Kobayashi, T, Geneugelijk, K & Spierings, E 2021, 'T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation', Frontiers in Immunology, vol. 12, 784040. https://doi.org/10.3389/fimmu.2021.784040

T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation. / Peereboom, Emma T M; Matern, Benedict M; Tomosugi, Toshihide; Niemann, Matthias; Drylewicz, Julia; Joosten, Irma; Allebes, Wil A; van der Meer, Arnold; Hilbrands, Luuk B; Baas, Marije C; van Reekum, Franka E; Verhaar, Marianne C; Kamburova, Elena G; Seelen, Marc A J; Sanders, Jan Stephan; Hepkema, Bouke G; Lambeck, Annechien J; Bungener, Laura B; Roozendaal, Caroline; Tilanus, Marcel G J; Voorter, Christien E ; Wieten, Lotte ; van Duijnhoven, Elly M ; Gelens, Mariëlle A C J ; Christiaans, Maarten H L; van Ittersum, Frans J; Nurmohamed, Azam; Lardy, Neubury M; Swelsen, Wendy; van der Pant, Karlijn A; van der Weerd, Neelke C; Ten Berge, Ineke J M; Bemelman, Fréderike J; de Vries, Aiko P J; de Fijter, Johan W; Betjes, Michiel G H; Roelen, Dave L; Claas, Frans H; Otten, Henny G; Heidt, Sebastiaan; van Zuilen, Arjan D; Kobayashi, Takaaki; Geneugelijk, Kirsten; Spierings, Eric.

In: Frontiers in Immunology, Vol. 12, 784040, 18.11.2021.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

AU - Peereboom, Emma T M

AU - Matern, Benedict M

AU - Tomosugi, Toshihide

AU - Niemann, Matthias

AU - Drylewicz, Julia

AU - Joosten, Irma

AU - Allebes, Wil A

AU - van der Meer, Arnold

AU - Hilbrands, Luuk B

AU - Baas, Marije C

AU - van Reekum, Franka E

AU - Verhaar, Marianne C

AU - Kamburova, Elena G

AU - Seelen, Marc A J

AU - Sanders, Jan Stephan

AU - Hepkema, Bouke G

AU - Lambeck, Annechien J

AU - Bungener, Laura B

AU - Roozendaal, Caroline

AU - Tilanus, Marcel G J

AU - Voorter, Christien E

AU - Wieten, Lotte

AU - van Duijnhoven, Elly M

AU - Gelens, Mariëlle A C J

AU - Christiaans, Maarten H L

AU - van Ittersum, Frans J

AU - Nurmohamed, Azam

AU - Lardy, Neubury M

AU - Swelsen, Wendy

AU - van der Pant, Karlijn A

AU - van der Weerd, Neelke C

AU - Ten Berge, Ineke J M

AU - Bemelman, Fréderike J

AU - de Vries, Aiko P J

AU - de Fijter, Johan W

AU - Betjes, Michiel G H

AU - Roelen, Dave L

AU - Claas, Frans H

AU - Otten, Henny G

AU - Heidt, Sebastiaan

AU - van Zuilen, Arjan D

AU - Kobayashi, Takaaki

AU - Geneugelijk, Kirsten

AU - Spierings, Eric

N1 - .

PY - 2021/11/18

Y1 - 2021/11/18

KW - HLA antigens

KW - PIRCHE-II

KW - graft failure

KW - kidney transplantation

KW - shared T-cell epitopes

KW - T-cell epitope

KW - T-cell memory

KW - ANTIBODY-MEDIATED REJECTION

KW - INDIRECT RECOGNITION

KW - CROSS-VALIDATION

KW - DR PEPTIDES

KW - ANTIGEN

KW - LYMPHOCYTES

KW - ALLOCATION

KW - MEMORY

KW - ASSAY

KW - HELP

U2 - 10.3389/fimmu.2021.784040

DO - 10.3389/fimmu.2021.784040

M3 - Article

C2 - 34868064

VL - 12

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 784040

ER -