T-1 rho Mapping for the Evaluation of High Intensity Focused Ultrasound Tumor Treatment

Stefanie J. C. G. Hectors*, Rik P. M. Moonen, Gustav J. Strijkers, Klaas Nicolay

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


This study was aimed to assess the effects of High Intensity Focused Ultrasound (HIFU) thermal ablation on tumor T1? .In vivo T1? measurements of murine tumors at various spin-lock amplitudes (B1 = 0-2000 Hz) were performed before (n = 13), directly after (n = 13) and 3 days (n = 7) after HIFU treatment. T2 maps were obtained from the measurements at B1 = 0 Hz.Average tumor T1? distributions at the different experimental time points showed a shift toward lower T1? values after HIFU for all spin-lock amplitudes, which became larger with increasing spin-lock amplitude at 3 days after treatment. Statistical analysis confirmed a significant effect of spin-lock amplitude on the average change in T1? (?T1? ) as compared to baseline at 3 days after HIFU. At 3 days after treatment, ?T1? values at B1 above 100 Hz were significantly lower (more negative) than at B1 = 0 Hz (T2 ).Significant changes in tumor T1? were observed after HIFU treatment. These T1? changes were distinctly more pronounced than HIFU-induced changes in T2 . The results indicate that T1? imaging is sensitive to HIFU-induced tissue changes and may thus be a suitable MR method for the evaluation of HIFU treatment. Magn Reson Med 73:1593-1601, 2015. ? 2014? 2014
Original languageEnglish
Pages (from-to)1593-1601
JournalMagnetic Resonance in Medicine
Issue number4
Publication statusPublished - Apr 2015


  • T-1
  • spin-lock
  • high intensity focused ultrasound
  • cancer treatment response


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