Systolic Blood Pressure Variation and Mean Heart Rate Is Associated With Cognitive Dysfunction in Patients With High Cardiovascular Risk

Michael Boehm; Helmut Schumacher; Darryl Leong; Giuseppe Mancia; Thomas Unger; Roland Schmieder; Florian Custodis; Hans-Christoph Diener; Ulrich Laufs; Eva Lonn; Karen Sliwa; Koon Teo; Robert Fagard; Josep Redon; Peter Sleight; Craig Anderson; Martin O'Donnell; Salim Yusuf

doi:10.1161/HYPERTENSIONAHA.114.04568

Systolic Blood Pressure Variation and Mean Heart Rate Is Associated With Cognitive Dysfunction in Patients With High Cardiovascular Risk

Michael Boehm^*, Helmut Schumacher, Darryl Leong, Giuseppe Mancia, Thomas Unger, Roland Schmieder, Florian Custodis, Hans-Christoph Diener, Ulrich Laufs, Eva Lonn, Karen Sliwa, Koon Teo, Robert Fagard, Josep Redon, Peter Sleight, Craig Anderson, Martin O'Donnell, Salim Yusuf

^*Corresponding author for this work

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Abstract

Elevated systolic blood pressure (SBP) correlates to cognitive decline and incident dementia. The effects of heart rate (HR), visit to visit HR variation, and visit to visit SBP variation are less well established. Patients without preexisting cognitive dysfunction (N=24 593) were evaluated according to mean SBP, SBP visit to visit variation (coefficient of variation [standard deviation/meanx100%], CV), mean HR, and visit to visit HR variation (HR-CV) in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial and the Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease. Cognitive function was assessed with mini mental state examination. Cognitive dysfunction (fall in mini mental state examination = 5 points), and cognitive deterioration (drop of >1 point per year or decline to

Original language	English
Pages (from-to)	651-U336
Journal	Hypertension
Volume	65
Issue number	3
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.114.04568
Publication status	Published - Mar 2015

Keywords

heart rate
hypertension
myocardial infarction
stroke

Access to Document

10.1161/HYPERTENSIONAHA.114.04568

Cite this

Boehm, M., Schumacher, H., Leong, D., Mancia, G., Unger, T., Schmieder, R., Custodis, F., Diener, H.-C., Laufs, U., Lonn, E., Sliwa, K., Teo, K., Fagard, R., Redon, J., Sleight, P., Anderson, C., O'Donnell, M., & Yusuf, S. (2015). Systolic Blood Pressure Variation and Mean Heart Rate Is Associated With Cognitive Dysfunction in Patients With High Cardiovascular Risk. Hypertension, 65(3), 651-U336. https://doi.org/10.1161/HYPERTENSIONAHA.114.04568

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title = "Systolic Blood Pressure Variation and Mean Heart Rate Is Associated With Cognitive Dysfunction in Patients With High Cardiovascular Risk",

abstract = "Elevated systolic blood pressure (SBP) correlates to cognitive decline and incident dementia. The effects of heart rate (HR), visit to visit HR variation, and visit to visit SBP variation are less well established. Patients without preexisting cognitive dysfunction (N=24 593) were evaluated according to mean SBP, SBP visit to visit variation (coefficient of variation [standard deviation/meanx100%], CV), mean HR, and visit to visit HR variation (HR-CV) in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial and the Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease. Cognitive function was assessed with mini mental state examination. Cognitive dysfunction (fall in mini mental state examination = 5 points), and cognitive deterioration (drop of >1 point per year or decline to ",

keywords = "heart rate, hypertension, myocardial infarction, stroke",

author = "Michael Boehm and Helmut Schumacher and Darryl Leong and Giuseppe Mancia and Thomas Unger and Roland Schmieder and Florian Custodis and Hans-Christoph Diener and Ulrich Laufs and Eva Lonn and Karen Sliwa and Koon Teo and Robert Fagard and Josep Redon and Peter Sleight and Craig Anderson and Martin O'Donnell and Salim Yusuf",

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doi = "10.1161/HYPERTENSIONAHA.114.04568",

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Boehm, M, Schumacher, H, Leong, D, Mancia, G, Unger, T, Schmieder, R, Custodis, F, Diener, H-C, Laufs, U, Lonn, E, Sliwa, K, Teo, K, Fagard, R, Redon, J, Sleight, P, Anderson, C, O'Donnell, M & Yusuf, S 2015, 'Systolic Blood Pressure Variation and Mean Heart Rate Is Associated With Cognitive Dysfunction in Patients With High Cardiovascular Risk', Hypertension, vol. 65, no. 3, pp. 651-U336. https://doi.org/10.1161/HYPERTENSIONAHA.114.04568

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T1 - Systolic Blood Pressure Variation and Mean Heart Rate Is Associated With Cognitive Dysfunction in Patients With High Cardiovascular Risk

AU - Boehm, Michael

AU - Schumacher, Helmut

AU - Leong, Darryl

AU - Mancia, Giuseppe

AU - Unger, Thomas

AU - Schmieder, Roland

AU - Custodis, Florian

AU - Diener, Hans-Christoph

AU - Laufs, Ulrich

AU - Lonn, Eva

AU - Sliwa, Karen

AU - Teo, Koon

AU - Fagard, Robert

AU - Redon, Josep

AU - Sleight, Peter

AU - Anderson, Craig

AU - O'Donnell, Martin

AU - Yusuf, Salim

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