Systolic Blood Pressure Variation and Mean Heart Rate Is Associated With Cognitive Dysfunction in Patients With High Cardiovascular Risk

Michael Boehm*, Helmut Schumacher, Darryl Leong, Giuseppe Mancia, Thomas Unger, Roland Schmieder, Florian Custodis, Hans-Christoph Diener, Ulrich Laufs, Eva Lonn, Karen Sliwa, Koon Teo, Robert Fagard, Josep Redon, Peter Sleight, Craig Anderson, Martin O'Donnell, Salim Yusuf

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Elevated systolic blood pressure (SBP) correlates to cognitive decline and incident dementia. The effects of heart rate (HR), visit to visit HR variation, and visit to visit SBP variation are less well established. Patients without preexisting cognitive dysfunction (N=24 593) were evaluated according to mean SBP, SBP visit to visit variation (coefficient of variation [standard deviation/meanx100%], CV), mean HR, and visit to visit HR variation (HR-CV) in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial and the Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease. Cognitive function was assessed with mini mental state examination. Cognitive dysfunction (fall in mini mental state examination = 5 points), and cognitive deterioration (drop of >1 point per year or decline to
Original languageEnglish
Pages (from-to)651-U336
Issue number3
Publication statusPublished - Mar 2015


  • heart rate
  • hypertension
  • myocardial infarction
  • stroke

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