Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms

Jens Hansen; Josephine Galatioto; Cristina I Caescu; Pauline Arnaud; Rhodora C Calizo; Bart Spronck; Sae-Il Murtada; Roshan Borkar; Alan Weinberg; Evren U Azeloglu; Maria Bintanel-Morcillo; James M Gallo; Jay D Humphrey; Guillaume Jondeau; Catherine Boileau; Francesco Ramirez; Ravi Iyengar

doi:10.1172/jci.insight.127652

Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms

Jens Hansen, Josephine Galatioto, Cristina I Caescu, Pauline Arnaud, Rhodora C Calizo, Bart Spronck, Sae-Il Murtada, Roshan Borkar, Alan Weinberg, Evren U Azeloglu, Maria Bintanel-Morcillo, James M Gallo, Jay D Humphrey, Guillaume Jondeau, Catherine Boileau, Francesco Ramirez^*, Ravi Iyengar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Web of Science)

Original language	English
Article number	027652
Number of pages	16
Journal	JCI INSIGHT
Volume	4
Issue number	11
DOIs	https://doi.org/10.1172/jci.insight.127652
Publication status	Published - 6 Jun 2019
Externally published	Yes

Keywords

Animals
Aortic Aneurysm, Thoracic/drug therapy
Cardiovascular Agents/pharmacology
Disease Models, Animal
Drug Repositioning/methods
Gene Expression Profiling
Humans
Marfan Syndrome/complications
Mice
Mice, Transgenic
Transcriptome/drug effects
IDENTIFY
AORTIC-ANEURYSM
RECEPTOR
MARFAN
EXPRESSION SIGNATURES
INHIBITION
DISEASE
GENES
MICE
PROGRESSION

Access to Document

10.1172/jci.insight.127652

Cite this

Hansen, J., Galatioto, J., Caescu, C. I., Arnaud, P., Calizo, R. C., Spronck, B., Murtada, S-I., Borkar, R., Weinberg, A., Azeloglu, E. U., Bintanel-Morcillo, M., Gallo, J. M., Humphrey, J. D., Jondeau, G., Boileau, C., Ramirez, F., & Iyengar, R. (2019). Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms. JCI INSIGHT, 4(11), [027652]. https://doi.org/10.1172/jci.insight.127652

Hansen, Jens ; Galatioto, Josephine ; Caescu, Cristina I ; Arnaud, Pauline ; Calizo, Rhodora C ; Spronck, Bart ; Murtada, Sae-Il ; Borkar, Roshan ; Weinberg, Alan ; Azeloglu, Evren U ; Bintanel-Morcillo, Maria ; Gallo, James M ; Humphrey, Jay D ; Jondeau, Guillaume ; Boileau, Catherine ; Ramirez, Francesco ; Iyengar, Ravi. / Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms. In: JCI INSIGHT. 2019 ; Vol. 4, No. 11.

@article{5bb48844d5dc4bc69fe9a20fe1efecac,

title = "Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms",

keywords = "Animals, Aortic Aneurysm, Thoracic/drug therapy, Cardiovascular Agents/pharmacology, Disease Models, Animal, Drug Repositioning/methods, Gene Expression Profiling, Humans, Marfan Syndrome/complications, Mice, Mice, Transgenic, Transcriptome/drug effects, IDENTIFY, AORTIC-ANEURYSM, RECEPTOR, MARFAN, EXPRESSION SIGNATURES, INHIBITION, DISEASE, GENES, MICE, PROGRESSION",

author = "Jens Hansen and Josephine Galatioto and Caescu, {Cristina I} and Pauline Arnaud and Calizo, {Rhodora C} and Bart Spronck and Sae-Il Murtada and Roshan Borkar and Alan Weinberg and Azeloglu, {Evren U} and Maria Bintanel-Morcillo and Gallo, {James M} and Humphrey, {Jay D} and Guillaume Jondeau and Catherine Boileau and Francesco Ramirez and Ravi Iyengar",

year = "2019",

month = jun,

day = "6",

doi = "10.1172/jci.insight.127652",

language = "English",

volume = "4",

journal = "JCI INSIGHT",

issn = "2379-3708",

publisher = "American Society for Clinical Investigation",

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}

Hansen, J, Galatioto, J, Caescu, CI, Arnaud, P, Calizo, RC, Spronck, B, Murtada, S-I, Borkar, R, Weinberg, A, Azeloglu, EU, Bintanel-Morcillo, M, Gallo, JM, Humphrey, JD, Jondeau, G, Boileau, C, Ramirez, F & Iyengar, R 2019, 'Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms', JCI INSIGHT, vol. 4, no. 11, 027652. https://doi.org/10.1172/jci.insight.127652

Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms. / Hansen, Jens; Galatioto, Josephine; Caescu, Cristina I; Arnaud, Pauline; Calizo, Rhodora C; Spronck, Bart; Murtada, Sae-Il; Borkar, Roshan; Weinberg, Alan; Azeloglu, Evren U; Bintanel-Morcillo, Maria; Gallo, James M; Humphrey, Jay D; Jondeau, Guillaume; Boileau, Catherine; Ramirez, Francesco; Iyengar, Ravi.

In: JCI INSIGHT, Vol. 4, No. 11, 027652, 06.06.2019.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms

AU - Hansen, Jens

AU - Galatioto, Josephine

AU - Caescu, Cristina I

AU - Arnaud, Pauline

AU - Calizo, Rhodora C

AU - Spronck, Bart

AU - Murtada, Sae-Il

AU - Borkar, Roshan

AU - Weinberg, Alan

AU - Azeloglu, Evren U

AU - Bintanel-Morcillo, Maria

AU - Gallo, James M

AU - Humphrey, Jay D

AU - Jondeau, Guillaume

AU - Boileau, Catherine

AU - Ramirez, Francesco

AU - Iyengar, Ravi

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KW - Disease Models, Animal

KW - Drug Repositioning/methods

KW - Gene Expression Profiling

KW - Humans

KW - Marfan Syndrome/complications

KW - Mice

KW - Mice, Transgenic

KW - Transcriptome/drug effects

KW - IDENTIFY

KW - AORTIC-ANEURYSM

KW - RECEPTOR

KW - MARFAN

KW - EXPRESSION SIGNATURES

KW - INHIBITION

KW - DISEASE

KW - GENES

KW - MICE

KW - PROGRESSION

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DO - 10.1172/jci.insight.127652

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