Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms

Jens Hansen, Josephine Galatioto, Cristina I Caescu, Pauline Arnaud, Rhodora C Calizo, Bart Spronck, Sae-Il Murtada, Roshan Borkar, Alan Weinberg, Evren U Azeloglu, Maria Bintanel-Morcillo, James M Gallo, Jay D Humphrey, Guillaume Jondeau, Catherine Boileau, Francesco Ramirez, Ravi Iyengar

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number027652
Number of pages16
JournalJCI INSIGHT
Volume4
Issue number11
DOIs
Publication statusPublished - 6 Jun 2019
Externally publishedYes

Keywords

  • Animals
  • Aortic Aneurysm, Thoracic/drug therapy
  • Cardiovascular Agents/pharmacology
  • Disease Models, Animal
  • Drug Repositioning/methods
  • Gene Expression Profiling
  • Humans
  • Marfan Syndrome/complications
  • Mice
  • Mice, Transgenic
  • Transcriptome/drug effects
  • IDENTIFY
  • AORTIC-ANEURYSM
  • RECEPTOR
  • MARFAN
  • EXPRESSION SIGNATURES
  • INHIBITION
  • DISEASE
  • GENES
  • MICE
  • PROGRESSION

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