Systems medicine and integrated care to combat chronic noncommunicable diseases

J. Bousquet; J.M. Anto; P. J. Sterk; I. M. Adcock; K. F. Chung; J. Roca; A. Agusti; C. Brightling; A. Cambon-Thomsen; A. Cesario; S. Abdelhak; S.E. Antonarakis; A. Avignon; A. Ballabio; E. Baraldi; A. Baranov; T. Bieber; J. Bockaert; S. Brahmachari; C. Brambilla; J. Bringer; M. Dauzat; I. Ernberg; L. Fabbri; P. Froguel; D. Galas; T. Gojobori; P. Hunter; C. Jorgensen; F. Kauffmann; P. Kourilsky; M.L. Kowalski; D. Lancet; C. L. Pen; J. Mallet; B. Mayosi; J. Mercier; A. Metspalu; J. H. Nadeau; G. Ninot; D. Noble; M. Öztürk; S. Palkonen; C. Prefaut; K. Rabe; E. Renard; R. G. Roberts; B. Samolinski; H.J. Schunemann; H. U. Simon; M. B. Soares; G. Superti-Furga; J. Tegner; S. Verjovski-Almeida; P. Wellstead; O. Wolkenhauer; E.F.M. Wouters; R. Balling; A. J. Brookes; D. Charron; C. Pison; Z. Chen; L. Hood; C. Auffray

doi:10.1186/gm259

Systems medicine and integrated care to combat chronic noncommunicable diseases

J. Bousquet^*, J.M. Anto, P. J. Sterk, I. M. Adcock, K. F. Chung, J. Roca, A. Agusti, C. Brightling, A. Cambon-Thomsen, A. Cesario, S. Abdelhak, S.E. Antonarakis, A. Avignon, A. Ballabio, E. Baraldi, A. Baranov, T. Bieber, J. Bockaert, S. Brahmachari, C. BrambillaJ. Bringer, M. Dauzat, I. Ernberg, L. Fabbri, P. Froguel, D. Galas, T. Gojobori, P. Hunter, C. Jorgensen, F. Kauffmann, P. Kourilsky, M.L. Kowalski, D. Lancet, C. L. Pen, J. Mallet, B. Mayosi, J. Mercier, A. Metspalu, J. H. Nadeau, G. Ninot, D. Noble, M. Öztürk, S. Palkonen, C. Prefaut, K. Rabe, E. Renard, R. G. Roberts, B. Samolinski, H.J. Schunemann, H. U. Simon, M. B. Soares, G. Superti-Furga, J. Tegner, S. Verjovski-Almeida, P. Wellstead, O. Wolkenhauer, E.F.M. Wouters, R. Balling, A. J. Brookes, D. Charron, C. Pison, Z. Chen, L. Hood, C. Auffray

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

ABSTRACT: We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems.

Original language	English
Pages (from-to)	43
Journal	Genome Medicine
Volume	3
Issue number	7
DOIs	https://doi.org/10.1186/gm259
Publication status	Published - 1 Jan 2011

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Bousquet, J., Anto, J. M., Sterk, P. J., Adcock, I. M., Chung, K. F., Roca, J., Agusti, A., Brightling, C., Cambon-Thomsen, A., Cesario, A., Abdelhak, S., Antonarakis, S. E., Avignon, A., Ballabio, A., Baraldi, E., Baranov, A., Bieber, T., Bockaert, J., Brahmachari, S., ... Auffray, C. (2011). Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Medicine, 3(7), 43. https://doi.org/10.1186/gm259

@article{adaf546a3aca4f07abf9217e9c25e020,

title = "Systems medicine and integrated care to combat chronic noncommunicable diseases",

abstract = "ABSTRACT: We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems.",

author = "J. Bousquet and J.M. Anto and Sterk, {P. J.} and Adcock, {I. M.} and Chung, {K. F.} and J. Roca and A. Agusti and C. Brightling and A. Cambon-Thomsen and A. Cesario and S. Abdelhak and S.E. Antonarakis and A. Avignon and A. Ballabio and E. Baraldi and A. Baranov and T. Bieber and J. Bockaert and S. Brahmachari and C. Brambilla and J. Bringer and M. Dauzat and I. Ernberg and L. Fabbri and P. Froguel and D. Galas and T. Gojobori and P. Hunter and C. Jorgensen and F. Kauffmann and P. Kourilsky and M.L. Kowalski and D. Lancet and Pen, {C. L.} and J. Mallet and B. Mayosi and J. Mercier and A. Metspalu and Nadeau, {J. H.} and G. Ninot and D. Noble and M. {\"O}zt{\"u}rk and S. Palkonen and C. Prefaut and K. Rabe and E. Renard and Roberts, {R. G.} and B. Samolinski and H.J. Schunemann and Simon, {H. U.} and Soares, {M. B.} and G. Superti-Furga and J. Tegner and S. Verjovski-Almeida and P. Wellstead and O. Wolkenhauer and E.F.M. Wouters and R. Balling and Brookes, {A. J.} and D. Charron and C. Pison and Z. Chen and L. Hood and C. Auffray",

year = "2011",

month = jan,

day = "1",

doi = "10.1186/gm259",

language = "English",

volume = "3",

pages = "43",

journal = "Genome Medicine",

issn = "1756-994X",

publisher = "BioMed Central Ltd",

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Bousquet, J, Anto, JM, Sterk, PJ, Adcock, IM, Chung, KF, Roca, J, Agusti, A, Brightling, C, Cambon-Thomsen, A, Cesario, A, Abdelhak, S, Antonarakis, SE, Avignon, A, Ballabio, A, Baraldi, E, Baranov, A, Bieber, T, Bockaert, J, Brahmachari, S, Brambilla, C, Bringer, J, Dauzat, M, Ernberg, I, Fabbri, L, Froguel, P, Galas, D, Gojobori, T, Hunter, P, Jorgensen, C, Kauffmann, F, Kourilsky, P, Kowalski, ML, Lancet, D, Pen, CL, Mallet, J, Mayosi, B, Mercier, J, Metspalu, A, Nadeau, JH, Ninot, G, Noble, D, Öztürk, M, Palkonen, S, Prefaut, C, Rabe, K, Renard, E, Roberts, RG, Samolinski, B, Schunemann, HJ, Simon, HU, Soares, MB, Superti-Furga, G, Tegner, J, Verjovski-Almeida, S, Wellstead, P, Wolkenhauer, O, Wouters, EFM, Balling, R, Brookes, AJ, Charron, D, Pison, C, Chen, Z, Hood, L & Auffray, C 2011, 'Systems medicine and integrated care to combat chronic noncommunicable diseases', Genome Medicine, vol. 3, no. 7, pp. 43. https://doi.org/10.1186/gm259

TY - JOUR

T1 - Systems medicine and integrated care to combat chronic noncommunicable diseases

AU - Bousquet, J.

AU - Anto, J.M.

AU - Sterk, P. J.

AU - Adcock, I. M.

AU - Chung, K. F.

AU - Roca, J.

AU - Agusti, A.

AU - Brightling, C.

AU - Cambon-Thomsen, A.

AU - Cesario, A.

AU - Abdelhak, S.

AU - Antonarakis, S.E.

AU - Avignon, A.

AU - Ballabio, A.

AU - Baraldi, E.

AU - Baranov, A.

AU - Bieber, T.

AU - Bockaert, J.

AU - Brahmachari, S.

AU - Brambilla, C.

AU - Bringer, J.

AU - Dauzat, M.

AU - Ernberg, I.

AU - Fabbri, L.

AU - Froguel, P.

AU - Galas, D.

AU - Gojobori, T.

AU - Hunter, P.

AU - Jorgensen, C.

AU - Kauffmann, F.

AU - Kourilsky, P.

AU - Kowalski, M.L.

AU - Lancet, D.

AU - Pen, C. L.

AU - Mallet, J.

AU - Mayosi, B.

AU - Mercier, J.

AU - Metspalu, A.

AU - Nadeau, J. H.

AU - Ninot, G.

AU - Noble, D.

AU - Öztürk, M.

AU - Palkonen, S.

AU - Prefaut, C.

AU - Rabe, K.

AU - Renard, E.

AU - Roberts, R. G.

AU - Samolinski, B.

AU - Schunemann, H.J.

AU - Simon, H. U.

AU - Soares, M. B.

AU - Superti-Furga, G.

AU - Tegner, J.

AU - Verjovski-Almeida, S.

AU - Wellstead, P.

AU - Wolkenhauer, O.

AU - Wouters, E.F.M.

AU - Balling, R.

AU - Brookes, A. J.

AU - Charron, D.

AU - Pison, C.

AU - Chen, Z.

AU - Hood, L.

AU - Auffray, C.

PY - 2011/1/1

Y1 - 2011/1/1

N2 - ABSTRACT: We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems.

AB - ABSTRACT: We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems.

U2 - 10.1186/gm259

DO - 10.1186/gm259

M3 - Article

C2 - 21745417

SN - 1756-994X

VL - 3

SP - 43

JO - Genome Medicine

JF - Genome Medicine

IS - 7

ER -

Systems medicine and integrated care to combat chronic noncommunicable diseases

Abstract

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