TY - JOUR
T1 - Systemic chemotherapy in addition to CRS-HIPEC for colorectal peritoneal metastases
T2 - A critical systematic review on the impact on overall survival
AU - van den Heuvel, Teun B M
AU - Lurvink, Robin J
AU - Rovers, Koen P B
AU - van Hellemond, Irene E G
AU - de Hingh, Ignace H J T
PY - 2024/11
Y1 - 2024/11
N2 - In patients with resectable colorectal peritoneal metastases, it is unclear whether systemic chemotherapy, in addition to cytoreductive surgery-hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), improves overall survival (OS). This systematic review of 12 retrospective studies involving 3721 patients aimed to summarize the available evidence. Contradictory results were found regarding the effectiveness of neoadjuvant, adjuvant, and perioperative systemic therapies on OS, with a high risk of bias. Available evidence remains inconclusive, stressing the need for prospective, randomized trials, like the ongoing Dutch CAIRO6-trial.
AB - In patients with resectable colorectal peritoneal metastases, it is unclear whether systemic chemotherapy, in addition to cytoreductive surgery-hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), improves overall survival (OS). This systematic review of 12 retrospective studies involving 3721 patients aimed to summarize the available evidence. Contradictory results were found regarding the effectiveness of neoadjuvant, adjuvant, and perioperative systemic therapies on OS, with a high risk of bias. Available evidence remains inconclusive, stressing the need for prospective, randomized trials, like the ongoing Dutch CAIRO6-trial.
KW - CRS-HIPEC
KW - colorectal cancer
KW - overall survival
KW - peritoneal metastases
KW - systematic review
KW - systemic chemotherapy
U2 - 10.1002/jso.27849
DO - 10.1002/jso.27849
M3 - (Systematic) Review article
SN - 1096-9098
VL - 130
SP - 1378
EP - 1389
JO - Journal of surgical oncology
JF - Journal of surgical oncology
IS - 6
ER -