Systemic biochemical markers of joint metabolism and inflammation in relation to radiographic parameters and pain of the knee: data from CHECK, a cohort of early-osteoarthritis subjects

W.E. van Spil*, S.C. Nair, M.B. Kinds, P.J. Emans, W.K.H.A. Hilberdink, P.M.J. Welsing, F.P.G.J. Lafeber

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objective: To investigate associations of biochemical markers of joint metabolism and inflammation with minimum joint space width (JSW) and osteophyte area (OP area) of knees showing no or doubtful radiographic osteoarthritis (OA) and to investigate whether these differed between painful and non-painful knees. Design: Serum (s-) and urinary (u-) levels of the cartilage markers uCTX-II, sCOMP, sPIIANP, and sCS846, bone markers uCTX-I, uNTX-I, sPINP, and sOC, synovial markers sPIIINP and sHA, and inflammation markers hsCRP and erythrocyte sedimentation rate (ESR) were assessed in subjects from CHECK (Cohort Hip and Cohort Knee) demonstrating Kellgren and Lawrence grade
Original languageEnglish
Pages (from-to)48-56
JournalOsteoarthritis and Cartilage
Issue number1
Publication statusPublished - 1 Jan 2015

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