TY - JOUR
T1 - Systemic biochemical markers of joint metabolism and inflammation in relation to radiographic parameters and pain of the knee: data from CHECK, a cohort of early-osteoarthritis subjects
AU - van Spil, W.E.
AU - Nair, S.C.
AU - Kinds, M.B.
AU - Emans, P.J.
AU - Hilberdink, W.K.H.A.
AU - Welsing, P.M.J.
AU - Lafeber, F.P.G.J.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Objective: To investigate associations of biochemical markers of joint metabolism and inflammation with minimum joint space width (JSW) and osteophyte area (OP area) of knees showing no or doubtful radiographic osteoarthritis (OA) and to investigate whether these differed between painful and non-painful knees. Design: Serum (s-) and urinary (u-) levels of the cartilage markers uCTX-II, sCOMP, sPIIANP, and sCS846, bone markers uCTX-I, uNTX-I, sPINP, and sOC, synovial markers sPIIINP and sHA, and inflammation markers hsCRP and erythrocyte sedimentation rate (ESR) were assessed in subjects from CHECK (Cohort Hip and Cohort Knee) demonstrating Kellgren and Lawrence grade
AB - Objective: To investigate associations of biochemical markers of joint metabolism and inflammation with minimum joint space width (JSW) and osteophyte area (OP area) of knees showing no or doubtful radiographic osteoarthritis (OA) and to investigate whether these differed between painful and non-painful knees. Design: Serum (s-) and urinary (u-) levels of the cartilage markers uCTX-II, sCOMP, sPIIANP, and sCS846, bone markers uCTX-I, uNTX-I, sPINP, and sOC, synovial markers sPIIINP and sHA, and inflammation markers hsCRP and erythrocyte sedimentation rate (ESR) were assessed in subjects from CHECK (Cohort Hip and Cohort Knee) demonstrating Kellgren and Lawrence grade
U2 - 10.1016/j.joca.2014.09.003
DO - 10.1016/j.joca.2014.09.003
M3 - Article
C2 - 25205017
SN - 1063-4584
VL - 23
SP - 48
EP - 56
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
IS - 1
ER -