Systemic and immunotoxicity of silver nanoparticles in an intravenous 28 days repeated dose toxicity study in rats

Keyphrases

• Repeated-dose Study 100%
• Repeated Dose Toxicity 100%
• Immunotoxicity 100%
• Silver Nanoparticles 100%
• Ag Nanoparticles (AgNPs) 100%
• Cell number 60%
• Spleen Cells 60%
• Nanosilver 60%
• Spleen 40%
• Immune Parameters 40%
• Interleukin-10 40%
• Toxic Effects 40%
• Systemic Toxicity 40%
• Natural Killer Cell Activity 40%
• Spleen Weight 40%
• High Dose 20%
• Interleukin-1β 20%
• Interleukin-6 20%
• Benchmark Dose 20%
• Immune System 20%
• Lymph Node 20%
• Human Exposure 20%
• Lipopolysaccharide 20%
• Cell Population 20%
• T Cells 20%
• Histopathological Examination 20%
• Liver 20%
• Alanine Aminotransferase 20%
• Neutrophil Granulocytes 20%
• Adverse Reactions 20%
• Liver Damage 20%
• Alkaline Phosphatase 20%
• B Cells 20%
• Growth Retardation 20%
• Serum IgE 20%
• Nanomaterials 20%
• Maximum Tolerated Dose 20%
• Intravenous Administration 20%
• Interferon-α (IFN-α) 20%
• Clinical Chemistry 20%
• Medical Products 20%
• Concanavalin A (Con A) 20%
• Consumer Products 20%
• Aspartate Transaminase 20%
• Brown pigment 20%
• Spleen Size 20%
• Black pigment 20%
• LPS Stimulation 20%
• Red Blood Cell Parameters 20%
• Hematology 20%
• Thymus Weight 20%
• Serum IgM 20%
• Antibacterial Activity 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Toxicity 100%
• Dose Toxicity 100%
• Interleukin 10 100%
• Immunotoxicity 100%
• Silver Nanoparticle 100%
• Critical Effect 100%
• Interleukin 6 50%
• Lipopolysaccharide 50%
• Tumor Necrosis Factor 50%
• Growth Retardation 50%
• Immunoglobulin E 50%
• Alkaline Phosphatase 50%
• Alanine Aminotransferase 50%
• Immunoglobulin M 50%
• Interleukin 1 50%
• Interferon 50%
• Liver Injury 50%
• Aspartate Aminotransferase 50%
• Antibacterial Activity 50%
• Nanomaterial 50%
• Concanavalin A 50%

INIS

• doses 100%
• rats 100%
• toxicity 100%
• weight 100%
• nanoparticles 100%
• silver 100%
• spleen 50%
• interleukins 50%
• spleen cells 37%
• liver 25%
• size 25%
• animals 25%
• production 25%
• transaminases 25%
• natural killer cells 25%
• humans 12%
• damage 12%
• control 12%
• comparative evaluations 12%
• blood 12%
• stimulation 12%
• suppression 12%
• blood cells 12%
• administration 12%
• populations 12%
• evaluation 12%
• lymph nodes 12%
• organs 12%
• chemistry 12%
• hematology 12%
• growth 12%
• accumulation 12%
• lipopolysaccharides 12%
• interferon 12%
• granulocytes 12%
• alkaline phosphatase 12%
• alanines 12%
• pigments 12%
• thymus 12%
• nanomaterials 12%
• consumer products 12%