Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia - A case series

Tirza Wouters; Natasja Hendriks; Margot Koeneman; Arnold-Jan Kruse; Anna van de Sande; Heleen J van Beekhuizen; Kees G Gerestein; Ruud L M Bekkers; Jurgen M J Piek

doi:10.1016/j.crwh.2019.e00105

Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia - A case series

Tirza Wouters^*, Natasja Hendriks, Margot Koeneman, Arnold-Jan Kruse, Anna van de Sande, Heleen J van Beekhuizen, Kees G Gerestein, Ruud L M Bekkers, Jurgen M J Piek

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Treatment for cervical intraepithelial neoplasia (CIN) often consists of an excisional procedure. However, less invasive treatment methods have been explored, such as topical treatment with imiquimod cream. Imiquimod has been proven to be effective in the regression of vulvar intraepithelial neoplasia (VIN) and vaginal intraepithelial neoplasia (VAIN). Previous studies have investigated the effect of imiquimod in CIN and showed well tolerated adverse effects. During a current study in the Netherlands, a number of adverse events have occurred. This case series presents a selection of these. Gynaecologists should be aware of the possible adverse effects of topical treatment with imiquimod cream.

Original language	English
Article number	e00105
Journal	Case Reports in Women's Health
Volume	21
DOIs	https://doi.org/10.1016/j.crwh.2019.e00105
Publication status	Published - Jan 2019

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10.1016/j.crwh.2019.e00105Licence: CC BY-NC-ND

Cite this

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title = "Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia - A case series",

abstract = "Treatment for cervical intraepithelial neoplasia (CIN) often consists of an excisional procedure. However, less invasive treatment methods have been explored, such as topical treatment with imiquimod cream. Imiquimod has been proven to be effective in the regression of vulvar intraepithelial neoplasia (VIN) and vaginal intraepithelial neoplasia (VAIN). Previous studies have investigated the effect of imiquimod in CIN and showed well tolerated adverse effects. During a current study in the Netherlands, a number of adverse events have occurred. This case series presents a selection of these. Gynaecologists should be aware of the possible adverse effects of topical treatment with imiquimod cream.",

author = "Tirza Wouters and Natasja Hendriks and Margot Koeneman and Arnold-Jan Kruse and {van de Sande}, Anna and {van Beekhuizen}, {Heleen J} and Gerestein, {Kees G} and Bekkers, {Ruud L M} and Piek, {Jurgen M J}",

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doi = "10.1016/j.crwh.2019.e00105",

language = "English",

volume = "21",

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T1 - Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia - A case series

AU - Wouters, Tirza

AU - Hendriks, Natasja

AU - Koeneman, Margot

AU - Kruse, Arnold-Jan

AU - van de Sande, Anna

AU - van Beekhuizen, Heleen J

AU - Gerestein, Kees G

AU - Bekkers, Ruud L M

AU - Piek, Jurgen M J

PY - 2019/1

Y1 - 2019/1

N2 - Treatment for cervical intraepithelial neoplasia (CIN) often consists of an excisional procedure. However, less invasive treatment methods have been explored, such as topical treatment with imiquimod cream. Imiquimod has been proven to be effective in the regression of vulvar intraepithelial neoplasia (VIN) and vaginal intraepithelial neoplasia (VAIN). Previous studies have investigated the effect of imiquimod in CIN and showed well tolerated adverse effects. During a current study in the Netherlands, a number of adverse events have occurred. This case series presents a selection of these. Gynaecologists should be aware of the possible adverse effects of topical treatment with imiquimod cream.

AB - Treatment for cervical intraepithelial neoplasia (CIN) often consists of an excisional procedure. However, less invasive treatment methods have been explored, such as topical treatment with imiquimod cream. Imiquimod has been proven to be effective in the regression of vulvar intraepithelial neoplasia (VIN) and vaginal intraepithelial neoplasia (VAIN). Previous studies have investigated the effect of imiquimod in CIN and showed well tolerated adverse effects. During a current study in the Netherlands, a number of adverse events have occurred. This case series presents a selection of these. Gynaecologists should be aware of the possible adverse effects of topical treatment with imiquimod cream.

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M3 - Article

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VL - 21

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