Systematic review of diagnostic methods for acute respiratory distress syndrome

L.A. Hagens*, N.F.L. Heijnen, M.R. Smit, M.J. Schultz, D.C.J.J. Bergmans, R.M. Schnabel, L.D.J. Bos, DARTS Consortium

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

2 Citations (Web of Science)

Abstract

Rationale: Acute respiratory distress syndrome (ARDS) is currently diagnosed by the Berlin definition, which does not include a direct measure of pulmonary oedema, endothelial permeability or pulmonary inflammation. We hypothesised that biomarkers of these processes have good diagnostic accuracy for ARDS.Methods: Medline and Scopus were searched for original diagnostic studies using minimally invasive testing. Primary outcome was the diagnostic accuracy per test and was categorised by control group. The methodological quality was assessed with QUADAS-2 tool. Biomarkers that had an area under the receiver operating characteristic curve (AUROCC) of >0.75 and were studied with minimal bias against an unselected control group were considered to be promising.Results: Forty-four articles were included. The median AUROCC for all evaluated tests was 0.80 (25th to 75th percentile: 0.72-0.88). The type of control group influenced the diagnostic accuracy (p=0.0095). Higher risk of bias was associated with higher diagnostic accuracy (AUROCC 0.75 for low-bias, 0.77 for intermediate-bias and 0.84 for high-bias studies; p=0.0023). Club cell protein 16 and soluble receptor for advanced glycation end-products in plasma and two panels with biomarkers of oxidative stress in breath showed good diagnostic accuracy in low-bias studies that compared ARDS patients to an unselected intensive care unit (ICU) population.Conclusion: This systematic review revealed only four diagnostic tests fulfilling stringent criteria for a promising biomarker in a low-bias setting. For implementation into the clinical setting, prospective studies in a general unselected ICU population with good methodological quality are needed.
Original languageEnglish
Article numberARTN 00504-2020
Number of pages11
JournalERJ Open Research
Volume7
Issue number1
DOIs
Publication statusPublished - 1 Jan 2021

Keywords

  • accuracy
  • acute lung injury
  • ards
  • biomarkers
  • breath condensate
  • lavage fluid
  • outcomes
  • plasma
  • pulmonary-edema
  • severity
  • BREATH CONDENSATE
  • ACUTE LUNG INJURY
  • PULMONARY-EDEMA
  • ACCURACY
  • BIOMARKERS
  • PLASMA
  • OUTCOMES
  • LAVAGE FLUID
  • ARDS
  • SEVERITY

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