Abstract
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are a leading cause of drug-induced liver injury (DILI) across the world. Ibuprofen is one of the most commonly used and safest NSAIDs, nevertheless reports on ibuprofen-induced hepatotoxicity are available. Aims To analyse previously published information on ibuprofen-induced liver injury for a better characterisation of its phenotypic expression. Method A systematic search was performed and information on ibuprofen-induced liver injury included in case series and case reports, in terms of demographic, clinical, biochemical and outcome data, was analysed. Results Twenty-two idiosyncratic ibuprofen hepatotoxicity cases were identified in the literature, suggesting a very low prevalence of this type of DILI. These patients had a mean age of 31 years and 55% were females. Mean cumulative dose of ibuprofen and time to onset were 30 g and 12 days, respectively. Hepatocellular injury was the most frequently involved liver injury pattern. Six cases developed vanishing bile duct syndrome. Full recovery occurred in 11 patients after a mean time of 14 weeks, whereas five cases evolved to acute liver failure leading to death/liver transplantation. Conclusions When assessing potential hepatotoxicity cases, physicians should keep in mind that ibuprofen has been associated with hepatotoxicity in the literature. Ibuprofen-associated DILI presents commonly as hepatocellular damage after a short latency period. Published reports on ibuprofen hepatotoxicity leading to liver failure resulting in liver transplantation or death are available. However, due to the apparent low absolute risk of ibuprofen-induced liver complications, ibuprofen can be regarded as an efficacious and safe NSAID.
Original language | English |
---|---|
Pages (from-to) | 603-611 |
Number of pages | 9 |
Journal | Alimentary Pharmacology & Therapeutics |
Volume | 51 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Mar 2020 |
Keywords
- chronic hepatitis-c
- hepatotoxicity
- nonsteroidal antiinflammatory drugs
- outcomes
- patient
- population
- stevens-johnson-syndrome
- therapy
- vanishing bile-duct
- POPULATION
- CHRONIC HEPATITIS-C
- THERAPY
- NONSTEROIDAL ANTIINFLAMMATORY DRUGS
- PATIENT
- OUTCOMES
- HEPATOTOXICITY
- VANISHING BILE-DUCT
- STEVENS-JOHNSON-SYNDROME