TY - JOUR
T1 - Systematic literature review of methodologies and data sources of existing economic models across the full spectrum of Alzheimer's disease and dementia from apparently healthy through disease progression to end of life care: a systematic review protocol
AU - Karagiannidou, Maria
AU - Wittenberg, Raphael
AU - Landeiro, Filipa Isabel Trigo
AU - Park, A-La
AU - Fry, Andra
AU - Knapp, Martin
AU - Gray, Alastair M.
AU - Tockhorn-Heidenreich, Antje
AU - Sanchez, Amparo Yovanna Castro
AU - Ghinai, Isaac
AU - Handels, Ron
AU - Lecomte, Pascal
AU - Wolstenholme, Jane
AU - ROADMAP Grp
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Introduction Dementia is one of the greatest health challenges the world will face in the coming decades, as it is one of the principal causes of disability and dependency among older people. Economic modelling is used widely across many health conditions to inform decisions on health and social care policy and practice. The aim of this literature review is to systematically identify, review and critically evaluate existing health economics models in dementia. We included the full spectrum of dementia, including Alzheimer's disease (AD), from preclinical stages through to severe dementia and end of life. This review forms part of the Real world Outcomes across the Alzheimer's Disease spectrum for better care: multimodal data Access Platform (ROADMAP) project. Methods and analysis Electronic searches were conducted in Medical Literature Analysis and Retrieval System Online, Excerpta Medica dataBASE, Economic Literature Database, NHS Economic Evaluation Database, Cochrane Central Register of Controlled Trials, Cost Effectiveness Analysis Registry, Research Papers in Economics, Database of Abstracts of Reviews of Effectiveness, Science Citation Index, Turning Research Into Practice and Open Grey for studies published between January 2000 and the end of June 2017. Two reviewers will independently assess each study against predefined eligibility criteria. A third reviewer will resolve any disagreement. Data will be extracted using a predefined data extraction form following best practice. Study quality will be assessed using the Phillips checklist for decision analytic modelling. A narrative synthesis will be used. Ethics and dissemination The results will be made available in a scientific peer-reviewed journal paper, will he presented at relevant conferences and will also be made available through the ROADMAP project.
AB - Introduction Dementia is one of the greatest health challenges the world will face in the coming decades, as it is one of the principal causes of disability and dependency among older people. Economic modelling is used widely across many health conditions to inform decisions on health and social care policy and practice. The aim of this literature review is to systematically identify, review and critically evaluate existing health economics models in dementia. We included the full spectrum of dementia, including Alzheimer's disease (AD), from preclinical stages through to severe dementia and end of life. This review forms part of the Real world Outcomes across the Alzheimer's Disease spectrum for better care: multimodal data Access Platform (ROADMAP) project. Methods and analysis Electronic searches were conducted in Medical Literature Analysis and Retrieval System Online, Excerpta Medica dataBASE, Economic Literature Database, NHS Economic Evaluation Database, Cochrane Central Register of Controlled Trials, Cost Effectiveness Analysis Registry, Research Papers in Economics, Database of Abstracts of Reviews of Effectiveness, Science Citation Index, Turning Research Into Practice and Open Grey for studies published between January 2000 and the end of June 2017. Two reviewers will independently assess each study against predefined eligibility criteria. A third reviewer will resolve any disagreement. Data will be extracted using a predefined data extraction form following best practice. Study quality will be assessed using the Phillips checklist for decision analytic modelling. A narrative synthesis will be used. Ethics and dissemination The results will be made available in a scientific peer-reviewed journal paper, will he presented at relevant conferences and will also be made available through the ROADMAP project.
KW - MILD COGNITIVE IMPAIRMENT
KW - ASSOCIATION WORKGROUPS
KW - DIAGNOSTIC GUIDELINES
KW - NATIONAL INSTITUTE
KW - TECHNOLOGY-ASSESSMENT
KW - COST-EFFECTIVENESS
KW - RECOMMENDATIONS
KW - MEMANTINE
U2 - 10.1136/bmjopen-2017-020638
DO - 10.1136/bmjopen-2017-020638
M3 - (Systematic) Review article
C2 - 29884696
SN - 2044-6055
VL - 8
JO - BMJ Open
JF - BMJ Open
IS - 6
M1 - e020638
ER -