TY - JOUR
T1 - Synthesis, structure and anti-cancer activity of osmium complexes bearing π-bound arene substituents and phosphane Co-Ligands: A review
T2 - A review
AU - Nabiyeva, Tomiris
AU - Marschner, Christoph
AU - Blom, Burgert
N1 - Funding Information:
We would like to thank Maastricht University and the Faculty of Science and Engineering for support.
Publisher Copyright:
© 2020 The Author(s)
PY - 2020/9/1
Y1 - 2020/9/1
N2 - While many examples of osmium complexes, as anti-cancer agents, have been reported and some reviews have been devoted to this topic, a particularly interesting and synthetically accessible sub-class of these compounds namely those bearing a π– bound arene and phosphane co-ligand have escaped review. These complexes have made a surprisingly late entry in the literature (2005) in terms of anti-cancer investigations. This is somewhat surprising considering the plethora of analogous complexes that have been reported for the lighter analogue, ruthenium. Herein we review all complexes, neutral and ionic, bearing the “(ƞ6-arene)Os(PR3)” moiety focusing on their synthesis, reactivity, structural features (by X-ray diffraction analysis) as well as anti-cancer biological activity. An attempt is made throughout the article to contrast these to each other and to analogous Ru systems, and a full summary of all existing in vitro biological data is presented.
AB - While many examples of osmium complexes, as anti-cancer agents, have been reported and some reviews have been devoted to this topic, a particularly interesting and synthetically accessible sub-class of these compounds namely those bearing a π– bound arene and phosphane co-ligand have escaped review. These complexes have made a surprisingly late entry in the literature (2005) in terms of anti-cancer investigations. This is somewhat surprising considering the plethora of analogous complexes that have been reported for the lighter analogue, ruthenium. Herein we review all complexes, neutral and ionic, bearing the “(ƞ6-arene)Os(PR3)” moiety focusing on their synthesis, reactivity, structural features (by X-ray diffraction analysis) as well as anti-cancer biological activity. An attempt is made throughout the article to contrast these to each other and to analogous Ru systems, and a full summary of all existing in vitro biological data is presented.
KW - Osmium complexes
KW - Phosphane ligands
KW - Arene moiety
KW - Anti-Cancer activity
KW - In vitro studies
KW - Biological studies
KW - GLUTATHIONE-S-TRANSFERASE
KW - NONSTEROIDAL ANTIINFLAMMATORY DRUGS
KW - METAL-BASED DRUGS
KW - ETHACRYNIC-ACID
KW - CATHEPSIN-B
KW - RUTHENIUM COMPLEXES
KW - IN-VIVO
KW - ANTIPROLIFERATIVE ACTIVITY
KW - ORGANOMETALLIC COMPOUNDS
KW - MOLECULAR-MECHANISMS
U2 - 10.1016/j.ejmech.2020.112483
DO - 10.1016/j.ejmech.2020.112483
M3 - (Systematic) Review article
C2 - 32592914
SN - 0223-5234
VL - 201
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
M1 - 112483
ER -