Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications

Simone M. Crivelli; Andreas Paulus; Jozef Markus; Matthias Bauwens; Dusan Berkes; Helga E. De Vries; Monique T. Mulder; Jochen Walter; Felix M. Mottaghy; Mario Losen; Pilar Martinez-Martinez

doi:10.3233/JAD-161231

Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications

Simone M. Crivelli, Andreas Paulus, Jozef Markus, Matthias Bauwens, Dusan Berkes, Helga E. De Vries, Monique T. Mulder, Jochen Walter, Felix M. Mottaghy, Mario Losen, Pilar Martinez-Martinez^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	783-794
Number of pages	12
Journal	Journal of Alzheimer's Disease
Volume	60
Issue number	3
DOIs	https://doi.org/10.3233/JAD-161231
Publication status	Published - 2017

Keywords

Alzheimer's disease
ceramide
ceramide transporter protein CERT
HPA-12
ANTIGEN-BINDING PROTEIN
POSITRON-EMISSION-TOMOGRAPHY
GOODPASTURE ANTIGEN
SPHINGOMYELIN SYNTHESIS
ENDOPLASMIC-RETICULUM
ALZHEIMERS-DISEASE
DRUG DEVELOPMENT
CERT
LIGANDS
ANALOGS

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10.3233/JAD-161231

Cite this

Crivelli, S. M., Paulus, A., Markus, J., Bauwens, M., Berkes, D., De Vries, H. E., Mulder, M. T., Walter, J., Mottaghy, F. M., Losen, M., & Martinez-Martinez, P. (2017). Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications. Journal of Alzheimer's Disease, 60(3), 783-794. https://doi.org/10.3233/JAD-161231

Crivelli, Simone M. ; Paulus, Andreas ; Markus, Jozef ; Bauwens, Matthias ; Berkes, Dusan ; De Vries, Helga E. ; Mulder, Monique T. ; Walter, Jochen ; Mottaghy, Felix M. ; Losen, Mario ; Martinez-Martinez, Pilar. / Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications. In: Journal of Alzheimer's Disease. 2017 ; Vol. 60, No. 3. pp. 783-794.

@article{e15ffd47cd82446db092971baa864b16,

title = "Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications",

keywords = "Alzheimer's disease, ceramide, ceramide transporter protein CERT, HPA-12, ANTIGEN-BINDING PROTEIN, POSITRON-EMISSION-TOMOGRAPHY, GOODPASTURE ANTIGEN, SPHINGOMYELIN SYNTHESIS, ENDOPLASMIC-RETICULUM, ALZHEIMERS-DISEASE, DRUG DEVELOPMENT, CERT, LIGANDS, ANALOGS",

author = "Crivelli, {Simone M.} and Andreas Paulus and Jozef Markus and Matthias Bauwens and Dusan Berkes and {De Vries}, {Helga E.} and Mulder, {Monique T.} and Jochen Walter and Mottaghy, {Felix M.} and Mario Losen and Pilar Martinez-Martinez",

year = "2017",

doi = "10.3233/JAD-161231",

language = "English",

volume = "60",

pages = "783--794",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

publisher = "IOS Press",

number = "3",

}

Crivelli, SM, Paulus, A, Markus, J, Bauwens, M, Berkes, D, De Vries, HE, Mulder, MT, Walter, J, Mottaghy, FM , Losen, M & Martinez-Martinez, P 2017, 'Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications', Journal of Alzheimer's Disease, vol. 60, no. 3, pp. 783-794. https://doi.org/10.3233/JAD-161231

Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications. / Crivelli, Simone M.; Paulus, Andreas; Markus, Jozef; Bauwens, Matthias; Berkes, Dusan; De Vries, Helga E.; Mulder, Monique T.; Walter, Jochen; Mottaghy, Felix M.; Losen, Mario ; Martinez-Martinez, Pilar.

In: Journal of Alzheimer's Disease, Vol. 60, No. 3, 2017, p. 783-794.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications

AU - Crivelli, Simone M.

AU - Paulus, Andreas

AU - Markus, Jozef

AU - Bauwens, Matthias

AU - Berkes, Dusan

AU - De Vries, Helga E.

AU - Mulder, Monique T.

AU - Walter, Jochen

AU - Mottaghy, Felix M.

AU - Losen, Mario

AU - Martinez-Martinez, Pilar

PY - 2017

Y1 - 2017

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KW - ceramide

KW - ceramide transporter protein CERT

KW - HPA-12

KW - ANTIGEN-BINDING PROTEIN

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - GOODPASTURE ANTIGEN

KW - SPHINGOMYELIN SYNTHESIS

KW - ENDOPLASMIC-RETICULUM

KW - ALZHEIMERS-DISEASE

KW - DRUG DEVELOPMENT

KW - CERT

KW - LIGANDS

KW - ANALOGS

U2 - 10.3233/JAD-161231

DO - 10.3233/JAD-161231

M3 - Article

VL - 60

SP - 783

EP - 794

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 3

ER -