Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications

Simone M. Crivelli, Andreas Paulus, Jozef Markus, Matthias Bauwens, Dusan Berkes, Helga E. De Vries, Monique T. Mulder, Jochen Walter, Felix M. Mottaghy, Mario Losen, Pilar Martinez-Martinez*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)783-794
Number of pages12
JournalJournal of Alzheimer's Disease
Volume60
Issue number3
DOIs
Publication statusPublished - 2017

Keywords

  • Alzheimer's disease
  • ceramide
  • ceramide transporter protein CERT
  • HPA-12
  • ANTIGEN-BINDING PROTEIN
  • POSITRON-EMISSION-TOMOGRAPHY
  • GOODPASTURE ANTIGEN
  • SPHINGOMYELIN SYNTHESIS
  • ENDOPLASMIC-RETICULUM
  • ALZHEIMERS-DISEASE
  • DRUG DEVELOPMENT
  • CERT
  • LIGANDS
  • ANALOGS

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