Synthesis of Functional Polymer Particles from Morita-Baylis-Hillman Polymerization

Gijs Ramakers, Claudio D'Incal, Mick Gagliardi, Daniel G. M. Molin, Tanja Junkers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Functional synthetic polymers are frequently explored for their use in the biomedical field. To fulfill the stringent demands of biodegradability and compatibility, the materials need to be versatile and tunable. Post-modification is often considered challenging for well-known degradable materials like poly(lactic acid) because of their chemical inertness. In this work a procedure is proposed to produce densely functionalized polymer particles using oligomeric precursors synthesized via the Morita-Baylis-Hillman reaction. This allows for a variety of post-modification reactions to serve bio-conjugation or tuning of the material properties. The particles are subjected to basic media and found to be degradable. Furthermore, cytotoxicity tests confirm good biocompatibility. Finally, as a proof of concept to demonstrate the versatility of the particles, post-modification reactions are carried out through the formation of imines.
Original languageEnglish
Article number1800678
Number of pages5
JournalMacromolecular Rapid Communications
Issue number23
Publication statusPublished - 1 Dec 2018


  • Baylis-Hillman
  • biodegradable particles
  • surface functionalization
  • thiol-ene

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