Synthesis of 5-substituted pyrrolo[1,2-b]pyridazines with antioxidant properties

O.B. Ostby*, L.L. Gundersen, F. Rise, O. Antonson, K. Fosnes, V. Larsen, A. Bast, I. Custers, G.R.M.M. Haenen

*Corresponding author for this work

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Synthesis of 5-substituted pyrrolo[1,2-b]pyridazines with antioxidant properties.

Ostby OB, Gundersen LL, Rise F, Antonsen O, Fosnes K, Larsen V, Bast A, Custers I, Haenen GR.

Department of Chemistry, University of Oslo, P.O. Box 1033, Blindern, N-0315 Oslo, Norway.

5-Substituted pyrrolo[1,2-b]pyridazines have been prepared by cyclisation of pyridazine with diphenylcyclopropenone followed by further functionalisations in the pyrrolo[1,2-b]pyridazine 5-position. Several compound exhibit profound inhibition of lipid peroxidation in vitro. Lipid peroxidation of boiled rat liver microsomes was induced by ascorbic acid/FeSO4 and the peroxidation was determined by measuring the thiobarbituric acid reactive material
Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalArchiv der Pharmazie
Publication statusPublished - 1 Jan 2001

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