Synthesis, Biological Evaluation, and Molecular Modeling of 1-Benzyl-1H-imidazoles as Selective Inhibitors of Aldosterone Synthase (CYP11B2)

Luc Roumen, Joris W. Peeters, Judith M. A. Emmen, Ilona P. E. Beugels, Erica M. G. Custers, Marcel De Gooyer, Ralf Plate, Koen Pieterse, Peter A. J. Hilbers, Jos F. M. Smits, Jef A. J. Vekemans, Dirk Leysen, Harry C. J. Ottenheijm, Henk M. Jannsen, J. J. Rob Hermans

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1712-1725
JournalJournal of Medicinal Chemistry
Volume53
Issue number4
DOIs
Publication statusPublished - 25 Feb 2010

Cite this

Roumen, L., Peeters, J. W., Emmen, J. M. A., Beugels, I. P. E., Custers, E. M. G., De Gooyer, M., Plate, R., Pieterse, K., Hilbers, P. A. J., Smits, J. F. M., Vekemans, J. A. J., Leysen, D., Ottenheijm, H. C. J., Jannsen, H. M., & Hermans, J. J. R. (2010). Synthesis, Biological Evaluation, and Molecular Modeling of 1-Benzyl-1H-imidazoles as Selective Inhibitors of Aldosterone Synthase (CYP11B2). Journal of Medicinal Chemistry, 53(4), 1712-1725. https://doi.org/10.1021/jm901356d