Synthesis and application of cNGR-containing imaging agents for detection of angiogenesis

Ingrid Dijkgraaf; Pieter Van de Vijver; Anouk Dirksen; Tilman M. Hackeng

doi:10.1016/j.bmc.2013.04.002

Synthesis and application of cNGR-containing imaging agents for detection of angiogenesis

Ingrid Dijkgraaf^*, Pieter Van de Vijver, Anouk Dirksen, Tilman M. Hackeng

^*Corresponding author for this work

Biochemie

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Web of Science)

Abstract

Angiogenesis is a multi-step process regulated by pro-and anti-angiogenic factors. Inhibition of angiogenesis is a potential anti cancer treatment strategy that is now investigated clinically. In addition, advances in the understanding of the angiogenic process have led to the development of new angiogenesis therapies for ischemic heart disease. Currently, researchers search for objective measures that indicate pharmacological responses to pro- and anti-angiogenic drugs and therefore, there is a great interest in techniques to visualize angiogenesis noninvasively. As CD13 is selectively expressed in angiogenic blood vessels, it can serve as a target for molecular imaging tracers to noninvasively visualize angiogenic processes in animal models and patients. Here, an overview on the currently used CD13 targeted molecular imaging probes for noninvasive visualization of angiogenesis is given.

Original language	English
Pages (from-to)	3555-3564
Journal	Bioorganic & Medicinal Chemistry
Volume	21
Issue number	12
DOIs	https://doi.org/10.1016/j.bmc.2013.04.002
Publication status	Published - 15 Jun 2013

Keywords

Angiogenesis
cNGR
Multimerization
Quantum dots
Molecular imaging

Access to Document

10.1016/j.bmc.2013.04.002

Cite this

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title = "Synthesis and application of cNGR-containing imaging agents for detection of angiogenesis",

abstract = "Angiogenesis is a multi-step process regulated by pro-and anti-angiogenic factors. Inhibition of angiogenesis is a potential anti cancer treatment strategy that is now investigated clinically. In addition, advances in the understanding of the angiogenic process have led to the development of new angiogenesis therapies for ischemic heart disease. Currently, researchers search for objective measures that indicate pharmacological responses to pro- and anti-angiogenic drugs and therefore, there is a great interest in techniques to visualize angiogenesis noninvasively. As CD13 is selectively expressed in angiogenic blood vessels, it can serve as a target for molecular imaging tracers to noninvasively visualize angiogenic processes in animal models and patients. Here, an overview on the currently used CD13 targeted molecular imaging probes for noninvasive visualization of angiogenesis is given. ",

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author = "Ingrid Dijkgraaf and {Van de Vijver}, Pieter and Anouk Dirksen and Hackeng, {Tilman M.}",

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AU - Dijkgraaf, Ingrid

AU - Van de Vijver, Pieter

AU - Dirksen, Anouk

AU - Hackeng, Tilman M.

PY - 2013/6/15

Y1 - 2013/6/15

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AB - Angiogenesis is a multi-step process regulated by pro-and anti-angiogenic factors. Inhibition of angiogenesis is a potential anti cancer treatment strategy that is now investigated clinically. In addition, advances in the understanding of the angiogenic process have led to the development of new angiogenesis therapies for ischemic heart disease. Currently, researchers search for objective measures that indicate pharmacological responses to pro- and anti-angiogenic drugs and therefore, there is a great interest in techniques to visualize angiogenesis noninvasively. As CD13 is selectively expressed in angiogenic blood vessels, it can serve as a target for molecular imaging tracers to noninvasively visualize angiogenic processes in animal models and patients. Here, an overview on the currently used CD13 targeted molecular imaging probes for noninvasive visualization of angiogenesis is given.

KW - Angiogenesis

KW - cNGR

KW - Multimerization

KW - Quantum dots

KW - Molecular imaging

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