Synergistic Targeting of alpha(v)beta(3) Integrin and Galectin-1 with Heteromultivalent Paramagnetic Liposomes for Combined MR Imaging and Treatment of Angiogenesis

Ewelina Kluza*, Daisy W. J. van der Schaft, Petra A. I. Hautvast, Willem J. M. Mulder, Kevin H. Mayo, Arjan W. Griffioen, Gustav J. Strijkers, Klaas Nicolay

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

110 Citations (Web of Science)

Abstract

Effective and specific targeting or nanoparticles is of paramount importance in the fields of targeted therapeutics and diagnostics. In the Current study, we investigated the targeting efficacy of nanoparticles that were functionalized with two angiogenesis-specific targeting ligands, an alpha(v)beta(3) integrin-specific and a galectin-1-specific peptide. We show in vitro, using optical techniques and MRI, that the dual-targeting approach produces synergistic targeting effects, causing a dramatically elevated uptake of nanoparticles as compared to single ligand targeting.
Original languageEnglish
Pages (from-to)52-58
JournalNano Letters
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Angiogenesis
  • magnetic resonance imaging
  • molecular imaging
  • synergistic targeting
  • anti-angiogenic therapy

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