Synergistic Targeting of alpha(v)beta(3) Integrin and Galectin-1 with Heteromultivalent Paramagnetic Liposomes for Combined MR Imaging and Treatment of Angiogenesis

Ewelina Kluza; Daisy W. J. van der Schaft; Petra A. I. Hautvast; Willem J. M. Mulder; Kevin H. Mayo; Arjan W. Griffioen; Gustav J. Strijkers; Klaas Nicolay

doi:10.1021/nl902659g

Synergistic Targeting of alpha(v)beta(3) Integrin and Galectin-1 with Heteromultivalent Paramagnetic Liposomes for Combined MR Imaging and Treatment of Angiogenesis

Ewelina Kluza^*, Daisy W. J. van der Schaft, Petra A. I. Hautvast, Willem J. M. Mulder, Kevin H. Mayo, Arjan W. Griffioen, Gustav J. Strijkers, Klaas Nicolay

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Effective and specific targeting or nanoparticles is of paramount importance in the fields of targeted therapeutics and diagnostics. In the Current study, we investigated the targeting efficacy of nanoparticles that were functionalized with two angiogenesis-specific targeting ligands, an alpha(v)beta(3) integrin-specific and a galectin-1-specific peptide. We show in vitro, using optical techniques and MRI, that the dual-targeting approach produces synergistic targeting effects, causing a dramatically elevated uptake of nanoparticles as compared to single ligand targeting.

Original language	English
Pages (from-to)	52-58
Journal	Nano Letters
Volume	10
Issue number	1
DOIs	https://doi.org/10.1021/nl902659g
Publication status	Published - Jan 2010

Keywords

Angiogenesis
magnetic resonance imaging
molecular imaging
synergistic targeting
anti-angiogenic therapy

Access to Document

10.1021/nl902659g

Cite this

Kluza, E., van der Schaft, D. W. J., Hautvast, P. A. I., Mulder, W. J. M., Mayo, K. H., Griffioen, A. W., Strijkers, G. J., & Nicolay, K. (2010). Synergistic Targeting of alpha(v)beta(3) Integrin and Galectin-1 with Heteromultivalent Paramagnetic Liposomes for Combined MR Imaging and Treatment of Angiogenesis. Nano Letters, 10(1), 52-58. https://doi.org/10.1021/nl902659g

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abstract = "Effective and specific targeting or nanoparticles is of paramount importance in the fields of targeted therapeutics and diagnostics. In the Current study, we investigated the targeting efficacy of nanoparticles that were functionalized with two angiogenesis-specific targeting ligands, an alpha(v)beta(3) integrin-specific and a galectin-1-specific peptide. We show in vitro, using optical techniques and MRI, that the dual-targeting approach produces synergistic targeting effects, causing a dramatically elevated uptake of nanoparticles as compared to single ligand targeting.",

keywords = "Angiogenesis, magnetic resonance imaging, molecular imaging, synergistic targeting, anti-angiogenic therapy",

author = "Ewelina Kluza and {van der Schaft}, {Daisy W. J.} and Hautvast, {Petra A. I.} and Mulder, {Willem J. M.} and Mayo, {Kevin H.} and Griffioen, {Arjan W.} and Strijkers, {Gustav J.} and Klaas Nicolay",

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Synergistic Targeting of alpha(v)beta(3) Integrin and Galectin-1 with Heteromultivalent Paramagnetic Liposomes for Combined MR Imaging and Treatment of Angiogenesis. / Kluza, Ewelina; van der Schaft, Daisy W. J.; Hautvast, Petra A. I. et al.
In: Nano Letters, Vol. 10, No. 1, 01.2010, p. 52-58.

Research output: Contribution to journal › Article › Academic › peer-review

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